Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants

Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants

© 2020 by the authors.

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Main Authors: Gómez del Pulgar, Eva M., Benítez-Páez, Alfonso, Sanz Herranz, Yolanda
Other Authors: European Commission
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2020
Subjects:Safety, Probiotics, Bacteroides uniformis, Inflammation, Liver, Obesity, Metabolic function,
Online Access:http://hdl.handle.net/10261/202425
http://dx.doi.org/10.13039/501100000780
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spelling dig-iata-es-10261-2024252022-12-22T08:31:41Z Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants Gómez del Pulgar, Eva M. Benítez-Páez, Alfonso Sanz Herranz, Yolanda European Commission Safety Probiotics Bacteroides uniformis Inflammation Liver Obesity Metabolic function © 2020 by the authors. The formulation of next-generation probiotics requires competent preclinical studies to show their efficacy and safety status. This study aims to confirm the safety of the prolonged oral use of Bacteroides uniformis CECT 7771, a strain that protected against metabolic disorders and obesity in preclinical trials, in a sub-chronic 90 day trial in animals. The safety assessment was conducted in male and female Wistar rats (n = 50) administered increasing doses (108 CFU/day, 109 CFU/day, or 1010 CFU/day) of B. uniformis CECT 7771, 1010 CFU/day of B. longum ATCC 15707T, which complies with the qualifying presumption of safety (QPS) status of the EU, or vehicle (placebo), as the control. Pancreatic, liver, and kidney functions and cytokine concentrations were analyzed. Bacterial translocation to peripheral tissues was evaluated, and colon integrity was investigated histologically. No adverse metabolic or tissue integrity alterations were associated with treatments; however, alanine aminotransferase levels and the ratio of anti-inflammatory to pro-inflammatory cytokines in serum indicated a potentially beneficial role of B. uniformis CECT 7771 at specific doses. Additionally, the microbial community structure was modified by the interventions, and potentially beneficial gut bacteria were increased. The results indicated that the oral consumption of B. uniformis CECT 7771 during a sub-chronic 90 day study in rats did not raise safety concerns. This study was fully supported by the EU Project MyNewGut (Grant agreement No. 613979) from the European Commission 7th Framework Program. Peer reviewed 2020-03-02T12:41:51Z 2020-03-02T12:41:51Z 2020 2020-03-02T12:41:51Z artículo http://purl.org/coar/resource_type/c_6501 Nutrients 12(2): 551 (2020) http://hdl.handle.net/10261/202425 10.3390/nu12020551 2072-6643 http://dx.doi.org/10.13039/501100000780 32093252 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/FP7/613979 Publisher’s version https://doi.org/10.3390/nu12020551 Sí open Multidisciplinary Digital Publishing Institute
institution IATA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-iata-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IATA España
language English
topic Safety
Probiotics
Bacteroides uniformis
Inflammation
Liver
Obesity
Metabolic function
Safety
Probiotics
Bacteroides uniformis
Inflammation
Liver
Obesity
Metabolic function
spellingShingle Safety
Probiotics
Bacteroides uniformis
Inflammation
Liver
Obesity
Metabolic function
Safety
Probiotics
Bacteroides uniformis
Inflammation
Liver
Obesity
Metabolic function
Gómez del Pulgar, Eva M.
Benítez-Páez, Alfonso
Sanz Herranz, Yolanda
Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants
description © 2020 by the authors.
author2 European Commission
author_facet European Commission
Gómez del Pulgar, Eva M.
Benítez-Páez, Alfonso
Sanz Herranz, Yolanda
format artículo
topic_facet Safety
Probiotics
Bacteroides uniformis
Inflammation
Liver
Obesity
Metabolic function
author Gómez del Pulgar, Eva M.
Benítez-Páez, Alfonso
Sanz Herranz, Yolanda
author_sort Gómez del Pulgar, Eva M.
title Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants
title_short Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants
title_full Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants
title_fullStr Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants
title_full_unstemmed Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants
title_sort safety assessment of bacteroides uniformis cect 7771, a symbiont of the gut microbiota in infants
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020
url http://hdl.handle.net/10261/202425
http://dx.doi.org/10.13039/501100000780
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