Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum

Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum

© 2019 by the authors.

Saved in:
Bibliographic Details
Main Authors: Cortés-Martín, Adrián, Romo Vaquero, María, García Mantrana, Izaskun, Rodríguez-Varela, Ana, Collado, María Carmen, Espín de Gea, Juan Carlos, Selma, María Victoria
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Published: Multidisciplinary Digital Publishing Institute 2019-09-03
Subjects:Ellagitannins, Polyphenols, Gut microbiome, Postpartum, Lactation, Body mass index, Gut dysbiosis,
Online Access:http://hdl.handle.net/10261/191376
http://dx.doi.org/10.13039/501100003329
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-iata-es-10261-191376
record_format koha
spelling dig-iata-es-10261-1913762021-12-28T16:11:54Z Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum Cortés-Martín, Adrián Romo Vaquero, María García Mantrana, Izaskun Rodríguez-Varela, Ana Collado, María Carmen Espín de Gea, Juan Carlos Selma, María Victoria Ministerio de Economía y Competitividad (España) Ellagitannins Polyphenols Gut microbiome Postpartum Lactation Body mass index Gut dysbiosis © 2019 by the authors. The metabolism of dietary polyphenols ellagitannins by the gut-microbiota allows the human stratification in urolithin metabotypes depending on the final urolithins produced. Metabotype-A only produces urolithin-A, metabotype-B yields urolithin-B and isourolithin-A in addition to urolithin-A, and metabotype 0 does not produce urolithins. Metabotype-A has been suggested to be ‘protective’, and metabotype-B dysbiotic-prone to cardiometabolic impairments. We analyzed the gut-microbiome of 40 healthy women and determined their metabotypes and enterotypes, and their associations with anthropometric and gut-microbial changes after 3 weeks, 4, 6, and 12 months postpartum. Metabotype-A was predominant in mothers who lost weight (≥2 kg) (75%) versus metabotype-B (54%). After delivery, the microbiota of metabotype-A mothers changed, unlike metabotype-B, which barely changed over 1 year. The metabotype-A discriminating bacteria correlated to the decrease of the women’s waist while some metabotype-B bacteria were inversely associated with a reduction of body mass index (BMI), waist, and waist-to-hip ratio. Metabotype-B was associated with a more robust and less modulating microbial and anthropometric profiles versus metabotype-A, in which these profiles were normalized through the 1-year follow-up postpartum. Consequently, urolithin metabotypes assessment could be a tool to anticipate the predisposition of women to normalize their anthropometric values and gut-microbiota, significantly altered during pregnancy and after childbirth. This work was supported by the Projects AGL2015-64124-R (MINECO, Spain). A.C.-M. is a holder of a predoctoral grant from MINECO (Spain). Peer reviewed 2019-09-23T13:54:53Z 2019-09-23T13:54:53Z 2019-09-03 2019-09-23T13:54:53Z artículo http://purl.org/coar/resource_type/c_6501 Nutrients 11(9): 2079 (2019) 2072-6643 http://hdl.handle.net/10261/191376 10.3390/nu11092079 2072-6643 http://dx.doi.org/10.13039/501100003329 31484413 #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-64124-R Publisher’s version https://doi.org/10.3390/nu11092079 Sí open Multidisciplinary Digital Publishing Institute
institution IATA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-iata-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IATA España
topic Ellagitannins
Polyphenols
Gut microbiome
Postpartum
Lactation
Body mass index
Gut dysbiosis
Ellagitannins
Polyphenols
Gut microbiome
Postpartum
Lactation
Body mass index
Gut dysbiosis
spellingShingle Ellagitannins
Polyphenols
Gut microbiome
Postpartum
Lactation
Body mass index
Gut dysbiosis
Ellagitannins
Polyphenols
Gut microbiome
Postpartum
Lactation
Body mass index
Gut dysbiosis
Cortés-Martín, Adrián
Romo Vaquero, María
García Mantrana, Izaskun
Rodríguez-Varela, Ana
Collado, María Carmen
Espín de Gea, Juan Carlos
Selma, María Victoria
Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum
description © 2019 by the authors.
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Cortés-Martín, Adrián
Romo Vaquero, María
García Mantrana, Izaskun
Rodríguez-Varela, Ana
Collado, María Carmen
Espín de Gea, Juan Carlos
Selma, María Victoria
format artículo
topic_facet Ellagitannins
Polyphenols
Gut microbiome
Postpartum
Lactation
Body mass index
Gut dysbiosis
author Cortés-Martín, Adrián
Romo Vaquero, María
García Mantrana, Izaskun
Rodríguez-Varela, Ana
Collado, María Carmen
Espín de Gea, Juan Carlos
Selma, María Victoria
author_sort Cortés-Martín, Adrián
title Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum
title_short Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum
title_full Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum
title_fullStr Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum
title_full_unstemmed Urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum
title_sort urolithin metabotypes can anticipate the different restoration of the gut microbiota and anthropometric profiles during the first year postpartum
publisher Multidisciplinary Digital Publishing Institute
publishDate 2019-09-03
url http://hdl.handle.net/10261/191376
http://dx.doi.org/10.13039/501100003329
work_keys_str_mv AT cortesmartinadrian urolithinmetabotypescananticipatethedifferentrestorationofthegutmicrobiotaandanthropometricprofilesduringthefirstyearpostpartum
AT romovaqueromaria urolithinmetabotypescananticipatethedifferentrestorationofthegutmicrobiotaandanthropometricprofilesduringthefirstyearpostpartum
AT garciamantranaizaskun urolithinmetabotypescananticipatethedifferentrestorationofthegutmicrobiotaandanthropometricprofilesduringthefirstyearpostpartum
AT rodriguezvarelaana urolithinmetabotypescananticipatethedifferentrestorationofthegutmicrobiotaandanthropometricprofilesduringthefirstyearpostpartum
AT colladomariacarmen urolithinmetabotypescananticipatethedifferentrestorationofthegutmicrobiotaandanthropometricprofilesduringthefirstyearpostpartum
AT espindegeajuancarlos urolithinmetabotypescananticipatethedifferentrestorationofthegutmicrobiotaandanthropometricprofilesduringthefirstyearpostpartum
AT selmamariavictoria urolithinmetabotypescananticipatethedifferentrestorationofthegutmicrobiotaandanthropometricprofilesduringthefirstyearpostpartum
_version_ 1777670094324760576

Similar Items