Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study

Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study

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8 páginas, 1 figura, 2 tablas

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Main Authors: Olivares, Marta, Benítez-Páez, Alfonso, Palma, Giada de, Capilla, Amalia, Nova, Esther, Castillejo, Gemma, Varea, Vicente, Marcos, Ascensión, Garrote, José Antonio, Polanco, Isabel, Donat, Ester, Ribes-Koninckx, Carmen, Calvo, Carmen, Ortigosa, Luis, Palau Martínez, Francesc, Sanz Herranz, Yolanda
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Language:English
Published: Taylor & Francis 2018-11-02
Subjects:HLA genotype, PCR, Celiac disease, Gut microbiota, Pathogenic bacteria,
Online Access:http://hdl.handle.net/10261/180955
http://dx.doi.org/10.13039/501100000781
http://dx.doi.org/10.13039/501100003329
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spelling dig-iata-es-10261-1809552022-12-22T08:27:51Z Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study Olivares, Marta Benítez-Páez, Alfonso Palma, Giada de Capilla, Amalia Nova, Esther Castillejo, Gemma Varea, Vicente Marcos, Ascensión Garrote, José Antonio Polanco, Isabel Donat, Ester Ribes-Koninckx, Carmen Calvo, Carmen Ortigosa, Luis Palau Martínez, Francesc Sanz Herranz, Yolanda Ministerio de Economía y Competitividad (España) European Research Council HLA genotype PCR Celiac disease Gut microbiota Pathogenic bacteria 8 páginas, 1 figura, 2 tablas Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors, whose interaction influences disease risk. The intestinal microbiota, including viruses and bacteria, could play a role in the pathological process leading to gluten intolerance. In this study, we investigated the prevalence of pathogens in the intestinal microbiota of infants at familial risk of developing CD. We included 127 full-term newborns with at least one first-degree relative with CD. Infants were classified according to milk-feeding practice (breastfeeding or formula feeding) and HLA-DQ genotype (low, intermediate or high genetic risk). The prevalence of pathogenic bacteria and viruses was assessed in the faeces of the infants at 7 days, 1 month and 4 months of age. The prevalence of Clostridium perfringens was higher in formula-fed infants than in breast-fed over the study period, and that of C. difficile at 4 months. Among breastfed infants, a higher prevalence of enterotoxigenic E. coli (ETEC) was found in infants with the highest genetic risk compared either to those with a low or intermediate risk. Among formula-fed infants, a higher prevalence of ETEC was also found in infants with a high genetic risk compared to those of intermediate risk. Our results show that specific factors, such as formula feeding and the HLA-DQ2 genotype, previously linked to a higher risk of developing CD, influence the presence of pathogenic bacteria differently in the intestinal microbiota in early life. Further studies are warranted to establish whether these associations are related to CD onset later in life. This work was supported by grants AGL2011-25169, AGL2014-52101-P and AGL2007-66126-C03-03/ALI (YS and FP) from the Spanish Ministry of Economy and Competitiveness (MINECO). The scholarship to MO from CSIC (JAEpre) and the contract to ABP from the European Union's Seventh Framework Program under the grant agreement no 613979 (MyNewGut) are also fully acknowledged. Peer reviewed 2019-05-06T11:38:51Z 2019-05-06T11:38:51Z 2018-11-02 artículo http://purl.org/coar/resource_type/c_6501 Gut Microbes 9(6):551-558 (2018) 1949-0976 http://hdl.handle.net/10261/180955 10.1080/19490976.2018.1451276 1949-0984 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100003329 29672211 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2011-25169 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-52101-P info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2007-66126-C03-03/ALI info:eu-repo/grantAgreement/EC/FP7/613979 Publisher's version http://dx.doi.org/10.1080/19490976.2018.1451276 Sí open Taylor & Francis Landes Bioscience
institution IATA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-iata-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IATA España
language English
topic HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
spellingShingle HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
Olivares, Marta
Benítez-Páez, Alfonso
Palma, Giada de
Capilla, Amalia
Nova, Esther
Castillejo, Gemma
Varea, Vicente
Marcos, Ascensión
Garrote, José Antonio
Polanco, Isabel
Donat, Ester
Ribes-Koninckx, Carmen
Calvo, Carmen
Ortigosa, Luis
Palau Martínez, Francesc
Sanz Herranz, Yolanda
Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
description 8 páginas, 1 figura, 2 tablas
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Olivares, Marta
Benítez-Páez, Alfonso
Palma, Giada de
Capilla, Amalia
Nova, Esther
Castillejo, Gemma
Varea, Vicente
Marcos, Ascensión
Garrote, José Antonio
Polanco, Isabel
Donat, Ester
Ribes-Koninckx, Carmen
Calvo, Carmen
Ortigosa, Luis
Palau Martínez, Francesc
Sanz Herranz, Yolanda
format artículo
topic_facet HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
author Olivares, Marta
Benítez-Páez, Alfonso
Palma, Giada de
Capilla, Amalia
Nova, Esther
Castillejo, Gemma
Varea, Vicente
Marcos, Ascensión
Garrote, José Antonio
Polanco, Isabel
Donat, Ester
Ribes-Koninckx, Carmen
Calvo, Carmen
Ortigosa, Luis
Palau Martínez, Francesc
Sanz Herranz, Yolanda
author_sort Olivares, Marta
title Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_short Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_full Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_fullStr Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_full_unstemmed Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_sort increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: the proficel study
publisher Taylor & Francis
publishDate 2018-11-02
url http://hdl.handle.net/10261/180955
http://dx.doi.org/10.13039/501100000781
http://dx.doi.org/10.13039/501100003329
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