Gut Microbiota and Mucosal Immunity in the Neonate
Gut microbiota colonization is a complex, dynamic, and step-wise process that is in constant development during the first years of life. This microbial settlement occurs in parallel with the maturation of the immune system, and alterations during this period, due to environmental and host factors, are considered to be potential determinants of health-outcomes later in life. Given that host–microbe interactions are mediated by the immune system response, it is important to understand the close relationship between immunity and the microbiota during birth, lactation, and early infancy. This work summarizes the evidence to date on early gut microbiota colonization, and how it influences the maturation of the infant immune system and health during the first 1000 days of life. This review will also address the influence of perinatal antibiotic intake and the importance of delivery mode and breastfeeding for an appropriate development of gut immunity.
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Format: | artículo biblioteca |
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Multidisciplinary Digital Publishing Institute
2018-07-17
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Subjects: | Gut microbiota, Postnatal immune development, Gut immunity, Breastfeeding, Probiotics, Antibiotics, |
Online Access: | http://hdl.handle.net/10261/169963 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100010198 |
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dig-iata-es-10261-1699632021-12-28T16:14:10Z Gut Microbiota and Mucosal Immunity in the Neonate Dzidic, Majda Boix-Amorós, Alba Selma Royo, Marta Mira, Alex Collado, María Carmen Ministerio de Economía, Industria y Competitividad (España) European Research Council Generalitat Valenciana European Commission Gut microbiota Postnatal immune development Gut immunity Breastfeeding Probiotics Antibiotics Gut microbiota colonization is a complex, dynamic, and step-wise process that is in constant development during the first years of life. This microbial settlement occurs in parallel with the maturation of the immune system, and alterations during this period, due to environmental and host factors, are considered to be potential determinants of health-outcomes later in life. Given that host–microbe interactions are mediated by the immune system response, it is important to understand the close relationship between immunity and the microbiota during birth, lactation, and early infancy. This work summarizes the evidence to date on early gut microbiota colonization, and how it influences the maturation of the infant immune system and health during the first 1000 days of life. This review will also address the influence of perinatal antibiotic intake and the importance of delivery mode and breastfeeding for an appropriate development of gut immunity. The authors would like to acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (ERC Starting Grant, project no. 639226) and the grants AGL2015-707487-P and BIO2015-68711-R from the Spanish Ministerio de Economía, Industria y Competitividad (MINECO). MSR would like to acknowledge the support from the Ayudas para la Contratación de Personal Investigador en Formación (ACIF) program of Generalitat Valenciana with the European Social Fund (ESF). Peer reviewed 2018-09-21T07:15:01Z 2018-09-21T07:15:01Z 2018-07-17 2018-09-21T07:15:01Z artículo http://purl.org/coar/resource_type/c_6501 Medical Sciences 6(3): 56 (2018) http://hdl.handle.net/10261/169963 10.3390/medsci6030056 2076-3271 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100010198 30018263 #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/639226 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-707487-P info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2015-68711-R Publisher's version https://doi.org/10.3390/medsci6030056 Sí open Multidisciplinary Digital Publishing Institute |
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Gut microbiota Postnatal immune development Gut immunity Breastfeeding Probiotics Antibiotics Gut microbiota Postnatal immune development Gut immunity Breastfeeding Probiotics Antibiotics |
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Gut microbiota Postnatal immune development Gut immunity Breastfeeding Probiotics Antibiotics Gut microbiota Postnatal immune development Gut immunity Breastfeeding Probiotics Antibiotics Dzidic, Majda Boix-Amorós, Alba Selma Royo, Marta Mira, Alex Collado, María Carmen Gut Microbiota and Mucosal Immunity in the Neonate |
description |
Gut microbiota colonization is a complex, dynamic, and step-wise process that is in constant development during the first years of life. This microbial settlement occurs in parallel with the maturation of the immune system, and alterations during this period, due to environmental and host factors, are considered to be potential determinants of health-outcomes later in life. Given that host–microbe interactions are mediated by the immune system response, it is important to understand the close relationship between immunity and the microbiota during birth, lactation, and early infancy. This work summarizes the evidence to date on early gut microbiota colonization, and how it influences the maturation of the infant immune system and health during the first 1000 days of life. This review will also address the influence of perinatal antibiotic intake and the importance of delivery mode and breastfeeding for an appropriate development of gut immunity. |
author2 |
Ministerio de Economía, Industria y Competitividad (España) |
author_facet |
Ministerio de Economía, Industria y Competitividad (España) Dzidic, Majda Boix-Amorós, Alba Selma Royo, Marta Mira, Alex Collado, María Carmen |
format |
artículo |
topic_facet |
Gut microbiota Postnatal immune development Gut immunity Breastfeeding Probiotics Antibiotics |
author |
Dzidic, Majda Boix-Amorós, Alba Selma Royo, Marta Mira, Alex Collado, María Carmen |
author_sort |
Dzidic, Majda |
title |
Gut Microbiota and Mucosal Immunity in the Neonate |
title_short |
Gut Microbiota and Mucosal Immunity in the Neonate |
title_full |
Gut Microbiota and Mucosal Immunity in the Neonate |
title_fullStr |
Gut Microbiota and Mucosal Immunity in the Neonate |
title_full_unstemmed |
Gut Microbiota and Mucosal Immunity in the Neonate |
title_sort |
gut microbiota and mucosal immunity in the neonate |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2018-07-17 |
url |
http://hdl.handle.net/10261/169963 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100010198 |
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