Generation of bioactive peptides during food processing

Large amounts of peptides are naturally generated in foods through the proteolysis phenomena taking place during processing. Such proteolysis is carried out either by endogenous enzymes in ripened foods or by the combined action of endogenous and microbial enzymes when fermented. Food proteins can also be isolated and hydrolysed by peptidases to produce hydrolysates. endo-peptidases act first followed by the successive action of exo-peptidases (mainly, tri- and di-peptidylpeptidases, aminopeptidases and carboxypeptidases). The generated peptides may be further hydrolysed through the gastrointestinal digestion resulting in a pool of peptides with different sequences and lengths, some of them with relevant bioactivity. However, these peptides should be absorbed intact through the intestinal barrier and reach the blood stream to exert their physiological action. This manuscript is reporting the enzymatic routes and strategies followed for the generation of bioactive peptides.

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Bibliographic Details
Main Authors: Toldrá Vilardell, Fidel, Reig, Milagro, Aristoy, María Concepción, Mora, Leticia
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Language:English
Published: Elsevier 2017-06-21
Subjects:Bioactive peptides, Proteomics, Proteolysis, Peptides, Enzymes, Peptidases, Exo-peptidases,
Online Access:http://hdl.handle.net/10261/166570
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
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spelling dig-iata-es-10261-1665702019-02-06T07:49:53Z Generation of bioactive peptides during food processing Toldrá Vilardell, Fidel Reig, Milagro Aristoy, María Concepción Mora, Leticia Ministerio de Economía y Competitividad (España) European Commission Bioactive peptides Proteomics Proteolysis Peptides Enzymes Peptidases Exo-peptidases Large amounts of peptides are naturally generated in foods through the proteolysis phenomena taking place during processing. Such proteolysis is carried out either by endogenous enzymes in ripened foods or by the combined action of endogenous and microbial enzymes when fermented. Food proteins can also be isolated and hydrolysed by peptidases to produce hydrolysates. endo-peptidases act first followed by the successive action of exo-peptidases (mainly, tri- and di-peptidylpeptidases, aminopeptidases and carboxypeptidases). The generated peptides may be further hydrolysed through the gastrointestinal digestion resulting in a pool of peptides with different sequences and lengths, some of them with relevant bioactivity. However, these peptides should be absorbed intact through the intestinal barrier and reach the blood stream to exert their physiological action. This manuscript is reporting the enzymatic routes and strategies followed for the generation of bioactive peptides. The research leading to these results received funding from Grant AGL2014-57367-R from the Spanish Ministry of Economy, Industry and Competitivity and FEDER funds and from the European Union 7th Framework Programme (FP7/2007-2013) under Grant Agreement 312090 (BACCHUS). Peer reviewed 2018-06-19T07:19:14Z 2018-06-19T07:19:14Z 2017-06-21 artículo http://purl.org/coar/resource_type/c_6501 Food Chemistry 267: 395-404 (2018) 0308-8146 http://hdl.handle.net/10261/166570 10.1016/j.foodchem.2017.06.119 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-57367-R info:eu-repo/grantAgreement/EC/FP7/312090 Postprint https://doi.org/10.1016/j.foodchem.2017.06.119 Sí open Elsevier
institution IATA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-iata-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IATA España
language English
topic Bioactive peptides
Proteomics
Proteolysis
Peptides
Enzymes
Peptidases
Exo-peptidases
Bioactive peptides
Proteomics
Proteolysis
Peptides
Enzymes
Peptidases
Exo-peptidases
spellingShingle Bioactive peptides
Proteomics
Proteolysis
Peptides
Enzymes
Peptidases
Exo-peptidases
Bioactive peptides
Proteomics
Proteolysis
Peptides
Enzymes
Peptidases
Exo-peptidases
Toldrá Vilardell, Fidel
Reig, Milagro
Aristoy, María Concepción
Mora, Leticia
Generation of bioactive peptides during food processing
description Large amounts of peptides are naturally generated in foods through the proteolysis phenomena taking place during processing. Such proteolysis is carried out either by endogenous enzymes in ripened foods or by the combined action of endogenous and microbial enzymes when fermented. Food proteins can also be isolated and hydrolysed by peptidases to produce hydrolysates. endo-peptidases act first followed by the successive action of exo-peptidases (mainly, tri- and di-peptidylpeptidases, aminopeptidases and carboxypeptidases). The generated peptides may be further hydrolysed through the gastrointestinal digestion resulting in a pool of peptides with different sequences and lengths, some of them with relevant bioactivity. However, these peptides should be absorbed intact through the intestinal barrier and reach the blood stream to exert their physiological action. This manuscript is reporting the enzymatic routes and strategies followed for the generation of bioactive peptides.
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Toldrá Vilardell, Fidel
Reig, Milagro
Aristoy, María Concepción
Mora, Leticia
format artículo
topic_facet Bioactive peptides
Proteomics
Proteolysis
Peptides
Enzymes
Peptidases
Exo-peptidases
author Toldrá Vilardell, Fidel
Reig, Milagro
Aristoy, María Concepción
Mora, Leticia
author_sort Toldrá Vilardell, Fidel
title Generation of bioactive peptides during food processing
title_short Generation of bioactive peptides during food processing
title_full Generation of bioactive peptides during food processing
title_fullStr Generation of bioactive peptides during food processing
title_full_unstemmed Generation of bioactive peptides during food processing
title_sort generation of bioactive peptides during food processing
publisher Elsevier
publishDate 2017-06-21
url http://hdl.handle.net/10261/166570
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
work_keys_str_mv AT toldravilardellfidel generationofbioactivepeptidesduringfoodprocessing
AT reigmilagro generationofbioactivepeptidesduringfoodprocessing
AT aristoymariaconcepcion generationofbioactivepeptidesduringfoodprocessing
AT moraleticia generationofbioactivepeptidesduringfoodprocessing
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