Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume's Nutritional Composition and Protein Quality
Common bean is a nutritious food legume widely appreciated by consumers worldwide. It is a staple food in Latin America, and a component of the Mediterranean diet, being an affordable source of protein with high potential as a gourmet food. Breeding for nutritional quality, including both macro and micronutrients, and meeting organoleptic consumers' preferences is a difficult task which is facilitated by uncovering the genetic basis of related traits. This study explored the diversity of 106 Portuguese common bean accessions, under two contrasting environments, to gain insight into the genetic basis of nutritional composition (ash, carbohydrates, fat, fiber, moisture, protein, and resistant starch contents) and protein quality (amino acid contents and trypsin inhibitor activity) traits through a genome-wide association study. Single-nucleotide polymorphism-trait associations were tested using linear mixed models accounting for the accessions' genetic relatedness. Mapping resolution to the gene level was achieved in 56% of the cases, with 102 candidate genes proposed for 136 genomic regions associated with trait variation. Only one marker-trait association was stable across environments, highlighting the associations' environment-specific nature and the importance of genotype × environment interaction for crops' local adaptation and quality. This study provides novel information to better understand the molecular mechanisms regulating the nutritional quality in common bean and promising molecular tools to aid future breeding efforts to answer consumers' concerns.
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Format: | artículo biblioteca |
Language: | English |
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Multidisciplinary Digital Publishing Institute
2022-01
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Subjects: | Trypsin inhibitors, GWAS, Phaseolus vulgaris, Amino acids, Carbohydrates, Fat, Fiber, Nutritional quality, Resistant starch, |
Online Access: | http://hdl.handle.net/10261/286816 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100001871 https://api.elsevier.com/content/abstract/scopus_id/85121470549 |
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dig-ias-es-10261-2868162024-05-14T20:37:01Z Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume's Nutritional Composition and Protein Quality Mendes, Francisco A. Leitão, Susana T. Correia, Verónica Mecha, Elsa Rubiales, Diego Bronze, Maria do Rosário Vaz Patto, María Carlota Fundação para a Ciência e a Tecnologia (Portugal) European Commission Trypsin inhibitors GWAS Phaseolus vulgaris Amino acids Carbohydrates Fat Fiber Nutritional quality Resistant starch Common bean is a nutritious food legume widely appreciated by consumers worldwide. It is a staple food in Latin America, and a component of the Mediterranean diet, being an affordable source of protein with high potential as a gourmet food. Breeding for nutritional quality, including both macro and micronutrients, and meeting organoleptic consumers' preferences is a difficult task which is facilitated by uncovering the genetic basis of related traits. This study explored the diversity of 106 Portuguese common bean accessions, under two contrasting environments, to gain insight into the genetic basis of nutritional composition (ash, carbohydrates, fat, fiber, moisture, protein, and resistant starch contents) and protein quality (amino acid contents and trypsin inhibitor activity) traits through a genome-wide association study. Single-nucleotide polymorphism-trait associations were tested using linear mixed models accounting for the accessions' genetic relatedness. Mapping resolution to the gene level was achieved in 56% of the cases, with 102 candidate genes proposed for 136 genomic regions associated with trait variation. Only one marker-trait association was stable across environments, highlighting the associations' environment-specific nature and the importance of genotype × environment interaction for crops' local adaptation and quality. This study provides novel information to better understand the molecular mechanisms regulating the nutritional quality in common bean and promising molecular tools to aid future breeding efforts to answer consumers' concerns. Financial support by FCT—Fundação para a Ciência e a Tecnologia, I.P., Portugal, is acknowledged through research project BeGeQA (PTDC/AGR-TEC/3555/2012) and R&D Unit “GREEN-IT—Bioresources for Sustainability” (UIDB/04551/2020 and UIDP/04551/2020). The European Union Rural Development Program PDR2020 project (PDR2020-784-042734) is also acknowledged. Peer reviewed 2023-01-16T10:25:49Z 2023-01-16T10:25:49Z 2022-01 artículo http://purl.org/coar/resource_type/c_6501 Plants 11(1): 26 (2022) http://hdl.handle.net/10261/286816 10.3390/plants11010026 2223-7747 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100001871 35009030 2-s2.0-85121470549 https://api.elsevier.com/content/abstract/scopus_id/85121470549 en Publisher's version The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/plants11010026 https://doi.org/10.3390/plants11010026 Sí open application/pdf Multidisciplinary Digital Publishing Institute |
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Trypsin inhibitors GWAS Phaseolus vulgaris Amino acids Carbohydrates Fat Fiber Nutritional quality Resistant starch Trypsin inhibitors GWAS Phaseolus vulgaris Amino acids Carbohydrates Fat Fiber Nutritional quality Resistant starch |
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Trypsin inhibitors GWAS Phaseolus vulgaris Amino acids Carbohydrates Fat Fiber Nutritional quality Resistant starch Trypsin inhibitors GWAS Phaseolus vulgaris Amino acids Carbohydrates Fat Fiber Nutritional quality Resistant starch Mendes, Francisco A. Leitão, Susana T. Correia, Verónica Mecha, Elsa Rubiales, Diego Bronze, Maria do Rosário Vaz Patto, María Carlota Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume's Nutritional Composition and Protein Quality |
description |
Common bean is a nutritious food legume widely appreciated by consumers worldwide. It is a staple food in Latin America, and a component of the Mediterranean diet, being an affordable source of protein with high potential as a gourmet food. Breeding for nutritional quality, including both macro and micronutrients, and meeting organoleptic consumers' preferences is a difficult task which is facilitated by uncovering the genetic basis of related traits. This study explored the diversity of 106 Portuguese common bean accessions, under two contrasting environments, to gain insight into the genetic basis of nutritional composition (ash, carbohydrates, fat, fiber, moisture, protein, and resistant starch contents) and protein quality (amino acid contents and trypsin inhibitor activity) traits through a genome-wide association study. Single-nucleotide polymorphism-trait associations were tested using linear mixed models accounting for the accessions' genetic relatedness. Mapping resolution to the gene level was achieved in 56% of the cases, with 102 candidate genes proposed for 136 genomic regions associated with trait variation. Only one marker-trait association was stable across environments, highlighting the associations' environment-specific nature and the importance of genotype × environment interaction for crops' local adaptation and quality. This study provides novel information to better understand the molecular mechanisms regulating the nutritional quality in common bean and promising molecular tools to aid future breeding efforts to answer consumers' concerns. |
author2 |
Fundação para a Ciência e a Tecnologia (Portugal) |
author_facet |
Fundação para a Ciência e a Tecnologia (Portugal) Mendes, Francisco A. Leitão, Susana T. Correia, Verónica Mecha, Elsa Rubiales, Diego Bronze, Maria do Rosário Vaz Patto, María Carlota |
format |
artículo |
topic_facet |
Trypsin inhibitors GWAS Phaseolus vulgaris Amino acids Carbohydrates Fat Fiber Nutritional quality Resistant starch |
author |
Mendes, Francisco A. Leitão, Susana T. Correia, Verónica Mecha, Elsa Rubiales, Diego Bronze, Maria do Rosário Vaz Patto, María Carlota |
author_sort |
Mendes, Francisco A. |
title |
Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume's Nutritional Composition and Protein Quality |
title_short |
Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume's Nutritional Composition and Protein Quality |
title_full |
Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume's Nutritional Composition and Protein Quality |
title_fullStr |
Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume's Nutritional Composition and Protein Quality |
title_full_unstemmed |
Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume's Nutritional Composition and Protein Quality |
title_sort |
portuguese common bean natural variation helps to clarify the genetic architecture of the legume's nutritional composition and protein quality |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022-01 |
url |
http://hdl.handle.net/10261/286816 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100001871 https://api.elsevier.com/content/abstract/scopus_id/85121470549 |
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