Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution
Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans.
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éléphant d'Afrique phylogénie caprin distribution géographique Bacillus anthracis plasmide animal sauvage Bacillus cereus acide hyaluronique http://aims.fao.org/aos/agrovoc/c_168 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_9040 http://aims.fao.org/aos/agrovoc/c_16014 http://aims.fao.org/aos/agrovoc/c_24103 http://aims.fao.org/aos/agrovoc/c_26384 http://aims.fao.org/aos/agrovoc/c_24855 http://aims.fao.org/aos/agrovoc/c_8500 http://aims.fao.org/aos/agrovoc/c_1433 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4027 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_1811 éléphant d'Afrique phylogénie caprin distribution géographique Bacillus anthracis plasmide animal sauvage Bacillus cereus acide hyaluronique http://aims.fao.org/aos/agrovoc/c_168 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_9040 http://aims.fao.org/aos/agrovoc/c_16014 http://aims.fao.org/aos/agrovoc/c_24103 http://aims.fao.org/aos/agrovoc/c_26384 http://aims.fao.org/aos/agrovoc/c_24855 http://aims.fao.org/aos/agrovoc/c_8500 http://aims.fao.org/aos/agrovoc/c_1433 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4027 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_1811 |
spellingShingle |
éléphant d'Afrique phylogénie caprin distribution géographique Bacillus anthracis plasmide animal sauvage Bacillus cereus acide hyaluronique http://aims.fao.org/aos/agrovoc/c_168 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_9040 http://aims.fao.org/aos/agrovoc/c_16014 http://aims.fao.org/aos/agrovoc/c_24103 http://aims.fao.org/aos/agrovoc/c_26384 http://aims.fao.org/aos/agrovoc/c_24855 http://aims.fao.org/aos/agrovoc/c_8500 http://aims.fao.org/aos/agrovoc/c_1433 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4027 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_1811 éléphant d'Afrique phylogénie caprin distribution géographique Bacillus anthracis plasmide animal sauvage Bacillus cereus acide hyaluronique http://aims.fao.org/aos/agrovoc/c_168 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_9040 http://aims.fao.org/aos/agrovoc/c_16014 http://aims.fao.org/aos/agrovoc/c_24103 http://aims.fao.org/aos/agrovoc/c_26384 http://aims.fao.org/aos/agrovoc/c_24855 http://aims.fao.org/aos/agrovoc/c_8500 http://aims.fao.org/aos/agrovoc/c_1433 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4027 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_1811 Antonation, Kym S. Grützmacher, Kim Dupke, Susann Mabon, Philip Zimmermann, Fee Lankester, Felix Peller, Tianna Feistner, Anna Todd, Angelique Herbinger, Ilka De Nys, Hélène Muyembe-Tamfun, Jean-Jacques Karhemere, Stomy Wittig, Roman M. Couacy-Hymann, Emmanuel Grunow, Roland Calvignac-Spencer, Sébastien Corbett, Cindi R. Klee, Silke R. Leendertz, Fabian Hubertus Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution |
description |
Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans. |
format |
article |
topic_facet |
éléphant d'Afrique phylogénie caprin distribution géographique Bacillus anthracis plasmide animal sauvage Bacillus cereus acide hyaluronique http://aims.fao.org/aos/agrovoc/c_168 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_9040 http://aims.fao.org/aos/agrovoc/c_16014 http://aims.fao.org/aos/agrovoc/c_24103 http://aims.fao.org/aos/agrovoc/c_26384 http://aims.fao.org/aos/agrovoc/c_24855 http://aims.fao.org/aos/agrovoc/c_8500 http://aims.fao.org/aos/agrovoc/c_1433 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4027 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_1811 |
author |
Antonation, Kym S. Grützmacher, Kim Dupke, Susann Mabon, Philip Zimmermann, Fee Lankester, Felix Peller, Tianna Feistner, Anna Todd, Angelique Herbinger, Ilka De Nys, Hélène Muyembe-Tamfun, Jean-Jacques Karhemere, Stomy Wittig, Roman M. Couacy-Hymann, Emmanuel Grunow, Roland Calvignac-Spencer, Sébastien Corbett, Cindi R. Klee, Silke R. Leendertz, Fabian Hubertus |
author_facet |
Antonation, Kym S. Grützmacher, Kim Dupke, Susann Mabon, Philip Zimmermann, Fee Lankester, Felix Peller, Tianna Feistner, Anna Todd, Angelique Herbinger, Ilka De Nys, Hélène Muyembe-Tamfun, Jean-Jacques Karhemere, Stomy Wittig, Roman M. Couacy-Hymann, Emmanuel Grunow, Roland Calvignac-Spencer, Sébastien Corbett, Cindi R. Klee, Silke R. Leendertz, Fabian Hubertus |
author_sort |
Antonation, Kym S. |
title |
Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution |
title_short |
Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution |
title_full |
Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution |
title_fullStr |
Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution |
title_full_unstemmed |
Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution |
title_sort |
bacillus cereus biovar anthracis causing anthrax in sub-saharan africa - chromosomal monophyly and broad geographic distribution |
url |
http://agritrop.cirad.fr/608849/ http://agritrop.cirad.fr/608849/1/Antonation_2016_bacillus.pdf |
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dig-cirad-fr-6088492024-04-10T12:02:48Z http://agritrop.cirad.fr/608849/ http://agritrop.cirad.fr/608849/ Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution. Antonation Kym S., Grützmacher Kim, Dupke Susann, Mabon Philip, Zimmermann Fee, Lankester Felix, Peller Tianna, Feistner Anna, Todd Angelique, Herbinger Ilka, De Nys Hélène, Muyembe-Tamfun Jean-Jacques, Karhemere Stomy, Wittig Roman M., Couacy-Hymann Emmanuel, Grunow Roland, Calvignac-Spencer Sébastien, Corbett Cindi R., Klee Silke R., Leendertz Fabian Hubertus. 2016. PLoS Neglected Tropical Diseases, 10 (9):e0004923, 14 p.https://doi.org/10.1371/journal.pntd.0004923 <https://doi.org/10.1371/journal.pntd.0004923> Bacillus cereus biovar anthracis causing anthrax in sub-saharan Africa - Chromosomal monophyly and broad geographic distribution Antonation, Kym S. Grützmacher, Kim Dupke, Susann Mabon, Philip Zimmermann, Fee Lankester, Felix Peller, Tianna Feistner, Anna Todd, Angelique Herbinger, Ilka De Nys, Hélène Muyembe-Tamfun, Jean-Jacques Karhemere, Stomy Wittig, Roman M. Couacy-Hymann, Emmanuel Grunow, Roland Calvignac-Spencer, Sébastien Corbett, Cindi R. Klee, Silke R. Leendertz, Fabian Hubertus eng 2016 PLoS Neglected Tropical Diseases éléphant d'Afrique phylogénie caprin distribution géographique Bacillus anthracis plasmide animal sauvage Bacillus cereus acide hyaluronique http://aims.fao.org/aos/agrovoc/c_168 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_9040 http://aims.fao.org/aos/agrovoc/c_16014 http://aims.fao.org/aos/agrovoc/c_24103 http://aims.fao.org/aos/agrovoc/c_26384 http://aims.fao.org/aos/agrovoc/c_24855 République démocratique du Congo République centrafricaine Cameroun Côte d'Ivoire Afrique Congo http://aims.fao.org/aos/agrovoc/c_8500 http://aims.fao.org/aos/agrovoc/c_1433 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4027 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_1811 Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/608849/1/Antonation_2016_bacillus.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.1371/journal.pntd.0004923 10.1371/journal.pntd.0004923 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0004923 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1371/journal.pntd.0004923 info:eu-repo/semantics/dataset/purl/https://www.ncbi.nlm.nih.gov/biosample/?term=SAMN03610233 info:eu-repo/semantics/dataset/purl/https://www.ncbi.nlm.nih.gov/biosample/?term=SAMN03610237 info:eu-repo/semantics/dataset/purl/https://figshare.com/articles/dataset/_i_Bacillus_cereus_i_Biovar_Anthracis_Causing_Anthrax_in_Sub-Saharan_Africa_Chromosomal_Monophyly_and_Broad_Geographic_Distribution/3815880 |