Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci
Supergenes are genetic architectures associated with discrete and concerted variation in multiple traits. It has long been suggested that supergenes control these complex polymorphisms by suppressing recombination between sets of coadapted genes. However, because recombination suppression hinders the dissociation of the individual effects of genes within supergenes, there is still little evidence that supergenes evolve by tightening linkage between coadapted genes. Here, combining a landmark-free phenotyping algorithm with multivariate genome-wide association studies, we dissected the genetic basis of wing pattern variation in the butterfly Heliconius numata. We show that the supergene controlling the striking wing pattern polymorphism displayed by this species contains several independent loci associated with different features of wing patterns. The three chromosomal inversions of this supergene suppress recombination between these loci, supporting the hypothesis that they may have evolved because they captured beneficial combinations of alleles. Some of these loci are, however, associated with colour variations only in a subset of morphs where the phenotype is controlled by derived inversion forms, indicating that they were recruited after the formation of the inversions. Our study shows that supergenes and clusters of adaptive loci in general may form via the evolution of chromosomal rearrangements suppressing recombination between co-adapted loci but also via the subsequent recruitment of linked adaptive mutations.
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Format: | article biblioteca |
Language: | eng |
Subjects: | variation génétique, supergène, phénotype, polymorphisme génétique, phylogénie, carte génétique, variation phénotypique, locus, comportement animal, évolution, génome, http://aims.fao.org/aos/agrovoc/c_15975, http://aims.fao.org/aos/agrovoc/c_14695, http://aims.fao.org/aos/agrovoc/c_5776, http://aims.fao.org/aos/agrovoc/c_24031, http://aims.fao.org/aos/agrovoc/c_13325, http://aims.fao.org/aos/agrovoc/c_24002, http://aims.fao.org/aos/agrovoc/c_903c4959, http://aims.fao.org/aos/agrovoc/c_24869, http://aims.fao.org/aos/agrovoc/c_8811, http://aims.fao.org/aos/agrovoc/c_2745, http://aims.fao.org/aos/agrovoc/c_3224, |
Online Access: | http://agritrop.cirad.fr/603316/ http://agritrop.cirad.fr/603316/1/Jayetal2022.pdf |
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dig-cirad-fr-6033162024-04-24T13:12:00Z http://agritrop.cirad.fr/603316/ http://agritrop.cirad.fr/603316/ Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci. Jay Paul, Leroy Manon, Le Poul Yann, Whibley Annabel, Arias Monica, Chouteau Mathieu, Joron Mathieu. 2022. Philosophical Transactions - Royal Society. Biological Sciences, 377 (1856), dossier Genomic architecture of supergenes: causes and evolutionary consequences, 14 p.https://doi.org/10.1098/rstb.2021.0193 <https://doi.org/10.1098/rstb.2021.0193> Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci Jay, Paul Leroy, Manon Le Poul, Yann Whibley, Annabel Arias, Monica Chouteau, Mathieu Joron, Mathieu eng 2022 Philosophical Transactions - Royal Society. Biological Sciences variation génétique supergène phénotype polymorphisme génétique phylogénie carte génétique variation phénotypique locus comportement animal évolution génome http://aims.fao.org/aos/agrovoc/c_15975 http://aims.fao.org/aos/agrovoc/c_14695 http://aims.fao.org/aos/agrovoc/c_5776 http://aims.fao.org/aos/agrovoc/c_24031 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_24002 http://aims.fao.org/aos/agrovoc/c_903c4959 http://aims.fao.org/aos/agrovoc/c_24869 http://aims.fao.org/aos/agrovoc/c_8811 http://aims.fao.org/aos/agrovoc/c_2745 http://aims.fao.org/aos/agrovoc/c_3224 Supergenes are genetic architectures associated with discrete and concerted variation in multiple traits. It has long been suggested that supergenes control these complex polymorphisms by suppressing recombination between sets of coadapted genes. However, because recombination suppression hinders the dissociation of the individual effects of genes within supergenes, there is still little evidence that supergenes evolve by tightening linkage between coadapted genes. Here, combining a landmark-free phenotyping algorithm with multivariate genome-wide association studies, we dissected the genetic basis of wing pattern variation in the butterfly Heliconius numata. We show that the supergene controlling the striking wing pattern polymorphism displayed by this species contains several independent loci associated with different features of wing patterns. The three chromosomal inversions of this supergene suppress recombination between these loci, supporting the hypothesis that they may have evolved because they captured beneficial combinations of alleles. Some of these loci are, however, associated with colour variations only in a subset of morphs where the phenotype is controlled by derived inversion forms, indicating that they were recruited after the formation of the inversions. Our study shows that supergenes and clusters of adaptive loci in general may form via the evolution of chromosomal rearrangements suppressing recombination between co-adapted loci but also via the subsequent recruitment of linked adaptive mutations. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/603316/1/Jayetal2022.pdf text cc_by_nd info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nd/4.0/ https://doi.org/10.1098/rstb.2021.0193 10.1098/rstb.2021.0193 info:eu-repo/semantics/altIdentifier/doi/10.1098/rstb.2021.0193 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1098/rstb.2021.0193 info:eu-repo/semantics/reference/purl/https://github.com/PaulYannJay/HeliconiusGWAS info:eu-repo/grantAgreement/ERC//ANR-12-JSV7-0005//(FRA) Origines des innovations évolutives et hybridation/HybEvol info:eu-repo/grantAgreement/ERC//ANR-18-CE02-0019//(FRA) Les conséquences de l'évolution d'un supergène/Supergene |
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variation génétique supergène phénotype polymorphisme génétique phylogénie carte génétique variation phénotypique locus comportement animal évolution génome http://aims.fao.org/aos/agrovoc/c_15975 http://aims.fao.org/aos/agrovoc/c_14695 http://aims.fao.org/aos/agrovoc/c_5776 http://aims.fao.org/aos/agrovoc/c_24031 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_24002 http://aims.fao.org/aos/agrovoc/c_903c4959 http://aims.fao.org/aos/agrovoc/c_24869 http://aims.fao.org/aos/agrovoc/c_8811 http://aims.fao.org/aos/agrovoc/c_2745 http://aims.fao.org/aos/agrovoc/c_3224 variation génétique supergène phénotype polymorphisme génétique phylogénie carte génétique variation phénotypique locus comportement animal évolution génome http://aims.fao.org/aos/agrovoc/c_15975 http://aims.fao.org/aos/agrovoc/c_14695 http://aims.fao.org/aos/agrovoc/c_5776 http://aims.fao.org/aos/agrovoc/c_24031 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_24002 http://aims.fao.org/aos/agrovoc/c_903c4959 http://aims.fao.org/aos/agrovoc/c_24869 http://aims.fao.org/aos/agrovoc/c_8811 http://aims.fao.org/aos/agrovoc/c_2745 http://aims.fao.org/aos/agrovoc/c_3224 |
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variation génétique supergène phénotype polymorphisme génétique phylogénie carte génétique variation phénotypique locus comportement animal évolution génome http://aims.fao.org/aos/agrovoc/c_15975 http://aims.fao.org/aos/agrovoc/c_14695 http://aims.fao.org/aos/agrovoc/c_5776 http://aims.fao.org/aos/agrovoc/c_24031 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_24002 http://aims.fao.org/aos/agrovoc/c_903c4959 http://aims.fao.org/aos/agrovoc/c_24869 http://aims.fao.org/aos/agrovoc/c_8811 http://aims.fao.org/aos/agrovoc/c_2745 http://aims.fao.org/aos/agrovoc/c_3224 variation génétique supergène phénotype polymorphisme génétique phylogénie carte génétique variation phénotypique locus comportement animal évolution génome http://aims.fao.org/aos/agrovoc/c_15975 http://aims.fao.org/aos/agrovoc/c_14695 http://aims.fao.org/aos/agrovoc/c_5776 http://aims.fao.org/aos/agrovoc/c_24031 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_24002 http://aims.fao.org/aos/agrovoc/c_903c4959 http://aims.fao.org/aos/agrovoc/c_24869 http://aims.fao.org/aos/agrovoc/c_8811 http://aims.fao.org/aos/agrovoc/c_2745 http://aims.fao.org/aos/agrovoc/c_3224 Jay, Paul Leroy, Manon Le Poul, Yann Whibley, Annabel Arias, Monica Chouteau, Mathieu Joron, Mathieu Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci |
description |
Supergenes are genetic architectures associated with discrete and concerted variation in multiple traits. It has long been suggested that supergenes control these complex polymorphisms by suppressing recombination between sets of coadapted genes. However, because recombination suppression hinders the dissociation of the individual effects of genes within supergenes, there is still little evidence that supergenes evolve by tightening linkage between coadapted genes. Here, combining a landmark-free phenotyping algorithm with multivariate genome-wide association studies, we dissected the genetic basis of wing pattern variation in the butterfly Heliconius numata. We show that the supergene controlling the striking wing pattern polymorphism displayed by this species contains several independent loci associated with different features of wing patterns. The three chromosomal inversions of this supergene suppress recombination between these loci, supporting the hypothesis that they may have evolved because they captured beneficial combinations of alleles. Some of these loci are, however, associated with colour variations only in a subset of morphs where the phenotype is controlled by derived inversion forms, indicating that they were recruited after the formation of the inversions. Our study shows that supergenes and clusters of adaptive loci in general may form via the evolution of chromosomal rearrangements suppressing recombination between co-adapted loci but also via the subsequent recruitment of linked adaptive mutations. |
format |
article |
topic_facet |
variation génétique supergène phénotype polymorphisme génétique phylogénie carte génétique variation phénotypique locus comportement animal évolution génome http://aims.fao.org/aos/agrovoc/c_15975 http://aims.fao.org/aos/agrovoc/c_14695 http://aims.fao.org/aos/agrovoc/c_5776 http://aims.fao.org/aos/agrovoc/c_24031 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_24002 http://aims.fao.org/aos/agrovoc/c_903c4959 http://aims.fao.org/aos/agrovoc/c_24869 http://aims.fao.org/aos/agrovoc/c_8811 http://aims.fao.org/aos/agrovoc/c_2745 http://aims.fao.org/aos/agrovoc/c_3224 |
author |
Jay, Paul Leroy, Manon Le Poul, Yann Whibley, Annabel Arias, Monica Chouteau, Mathieu Joron, Mathieu |
author_facet |
Jay, Paul Leroy, Manon Le Poul, Yann Whibley, Annabel Arias, Monica Chouteau, Mathieu Joron, Mathieu |
author_sort |
Jay, Paul |
title |
Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci |
title_short |
Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci |
title_full |
Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci |
title_fullStr |
Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci |
title_full_unstemmed |
Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci |
title_sort |
association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci |
url |
http://agritrop.cirad.fr/603316/ http://agritrop.cirad.fr/603316/1/Jayetal2022.pdf |
work_keys_str_mv |
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_version_ |
1798165090285912064 |