Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children

Scope: The purpose of the study is to characterize the chemical diversity in Rice bran (RB) lipidome and determine whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children. Methods and Results: Untargeted and targeted lipidomics via ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) were applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose-USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome was conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention (15 g/d) with a control or RB supplemented snack. Untargeted lipidomic revealed 118 lipids as the core of lipidome across all 17 varieties among which phospholipids were abundant and oxylipins present. Phytoprostanes and phytofurans were quantified and characterized. Lipidome analysis of the children plasma following RB consumption revealed the presence of novel polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption. Conclusion: The investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health-promoting properties especially interesting for people at risk for cardiometabolic disease.

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Main Authors: Barros Santos, Millena, Barouh, Nathalie, Lullien-Pellerin, Valérie, Micard, Valérie, Villeneuve, Pierre, Zhou, Bingqing, Oger, Camille, Vigor, Claire, Durand, Thierry, Larraz Ferreira, Mariana Simões, Bourlieu-Lacanal, Claire, Ryan, Elizabeth P.
Format: article biblioteca
Language:eng
Subjects:Q04 - Composition des produits alimentaires, S50 - Santé humaine, glycolipide, acide gras, métabolisme des lipides, métabolisme des phospholipides, lipide, enfant, phosphatide, son de riz, composition des aliments, http://aims.fao.org/aos/agrovoc/c_32670, http://aims.fao.org/aos/agrovoc/c_2818, http://aims.fao.org/aos/agrovoc/c_4361, http://aims.fao.org/aos/agrovoc/c_5802, http://aims.fao.org/aos/agrovoc/c_4362, http://aims.fao.org/aos/agrovoc/c_1547, http://aims.fao.org/aos/agrovoc/c_5803, http://aims.fao.org/aos/agrovoc/c_77d35680, http://aims.fao.org/aos/agrovoc/c_10961, http://aims.fao.org/aos/agrovoc/c_4073, http://aims.fao.org/aos/agrovoc/c_4540,
Online Access:http://agritrop.cirad.fr/603134/
http://agritrop.cirad.fr/603134/13/603134ed.pdf
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spelling dig-cirad-fr-6031342024-02-15T05:31:56Z http://agritrop.cirad.fr/603134/ http://agritrop.cirad.fr/603134/ Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children. Barros Santos Millena, Barouh Nathalie, Lullien-Pellerin Valérie, Micard Valérie, Villeneuve Pierre, Zhou Bingqing, Oger Camille, Vigor Claire, Durand Thierry, Larraz Ferreira Mariana Simões, Bourlieu-Lacanal Claire, Ryan Elizabeth P.. 2023. Molecular Nutrition and Food Research, 67 (6):2200111, 13 p.https://doi.org/10.1002/mnfr.202200111 <https://doi.org/10.1002/mnfr.202200111> Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children Barros Santos, Millena Barouh, Nathalie Lullien-Pellerin, Valérie Micard, Valérie Villeneuve, Pierre Zhou, Bingqing Oger, Camille Vigor, Claire Durand, Thierry Larraz Ferreira, Mariana Simões Bourlieu-Lacanal, Claire Ryan, Elizabeth P. eng 2023 Molecular Nutrition and Food Research Q04 - Composition des produits alimentaires S50 - Santé humaine glycolipide acide gras métabolisme des lipides métabolisme des phospholipides lipide enfant phosphatide son de riz composition des aliments http://aims.fao.org/aos/agrovoc/c_32670 http://aims.fao.org/aos/agrovoc/c_2818 http://aims.fao.org/aos/agrovoc/c_4361 http://aims.fao.org/aos/agrovoc/c_5802 http://aims.fao.org/aos/agrovoc/c_4362 http://aims.fao.org/aos/agrovoc/c_1547 http://aims.fao.org/aos/agrovoc/c_5803 http://aims.fao.org/aos/agrovoc/c_77d35680 http://aims.fao.org/aos/agrovoc/c_10961 Cambodge Mali http://aims.fao.org/aos/agrovoc/c_4073 http://aims.fao.org/aos/agrovoc/c_4540 Scope: The purpose of the study is to characterize the chemical diversity in Rice bran (RB) lipidome and determine whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children. Methods and Results: Untargeted and targeted lipidomics via ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) were applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose-USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome was conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention (15 g/d) with a control or RB supplemented snack. Untargeted lipidomic revealed 118 lipids as the core of lipidome across all 17 varieties among which phospholipids were abundant and oxylipins present. Phytoprostanes and phytofurans were quantified and characterized. Lipidome analysis of the children plasma following RB consumption revealed the presence of novel polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption. Conclusion: The investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health-promoting properties especially interesting for people at risk for cardiometabolic disease. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/603134/13/603134ed.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.1002/mnfr.202200111 10.1002/mnfr.202200111 info:eu-repo/semantics/altIdentifier/doi/10.1002/mnfr.202200111 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1002/mnfr.202200111 info:eu-repo/grantAgreement///2016-67001-24538//(USA) Rice bran and bean metabolomes for human dietary exposure biomarkers/
institution CIRAD FR
collection DSpace
country Francia
countrycode FR
component Bibliográfico
access En linea
databasecode dig-cirad-fr
tag biblioteca
region Europa del Oeste
libraryname Biblioteca del CIRAD Francia
language eng
topic Q04 - Composition des produits alimentaires
S50 - Santé humaine
glycolipide
acide gras
métabolisme des lipides
métabolisme des phospholipides
lipide
enfant
phosphatide
son de riz
composition des aliments
http://aims.fao.org/aos/agrovoc/c_32670
http://aims.fao.org/aos/agrovoc/c_2818
http://aims.fao.org/aos/agrovoc/c_4361
http://aims.fao.org/aos/agrovoc/c_5802
http://aims.fao.org/aos/agrovoc/c_4362
http://aims.fao.org/aos/agrovoc/c_1547
http://aims.fao.org/aos/agrovoc/c_5803
http://aims.fao.org/aos/agrovoc/c_77d35680
http://aims.fao.org/aos/agrovoc/c_10961
http://aims.fao.org/aos/agrovoc/c_4073
http://aims.fao.org/aos/agrovoc/c_4540
Q04 - Composition des produits alimentaires
S50 - Santé humaine
glycolipide
acide gras
métabolisme des lipides
métabolisme des phospholipides
lipide
enfant
phosphatide
son de riz
composition des aliments
http://aims.fao.org/aos/agrovoc/c_32670
http://aims.fao.org/aos/agrovoc/c_2818
http://aims.fao.org/aos/agrovoc/c_4361
http://aims.fao.org/aos/agrovoc/c_5802
http://aims.fao.org/aos/agrovoc/c_4362
http://aims.fao.org/aos/agrovoc/c_1547
http://aims.fao.org/aos/agrovoc/c_5803
http://aims.fao.org/aos/agrovoc/c_77d35680
http://aims.fao.org/aos/agrovoc/c_10961
http://aims.fao.org/aos/agrovoc/c_4073
http://aims.fao.org/aos/agrovoc/c_4540
spellingShingle Q04 - Composition des produits alimentaires
S50 - Santé humaine
glycolipide
acide gras
métabolisme des lipides
métabolisme des phospholipides
lipide
enfant
phosphatide
son de riz
composition des aliments
http://aims.fao.org/aos/agrovoc/c_32670
http://aims.fao.org/aos/agrovoc/c_2818
http://aims.fao.org/aos/agrovoc/c_4361
http://aims.fao.org/aos/agrovoc/c_5802
http://aims.fao.org/aos/agrovoc/c_4362
http://aims.fao.org/aos/agrovoc/c_1547
http://aims.fao.org/aos/agrovoc/c_5803
http://aims.fao.org/aos/agrovoc/c_77d35680
http://aims.fao.org/aos/agrovoc/c_10961
http://aims.fao.org/aos/agrovoc/c_4073
http://aims.fao.org/aos/agrovoc/c_4540
Q04 - Composition des produits alimentaires
S50 - Santé humaine
glycolipide
acide gras
métabolisme des lipides
métabolisme des phospholipides
lipide
enfant
phosphatide
son de riz
composition des aliments
http://aims.fao.org/aos/agrovoc/c_32670
http://aims.fao.org/aos/agrovoc/c_2818
http://aims.fao.org/aos/agrovoc/c_4361
http://aims.fao.org/aos/agrovoc/c_5802
http://aims.fao.org/aos/agrovoc/c_4362
http://aims.fao.org/aos/agrovoc/c_1547
http://aims.fao.org/aos/agrovoc/c_5803
http://aims.fao.org/aos/agrovoc/c_77d35680
http://aims.fao.org/aos/agrovoc/c_10961
http://aims.fao.org/aos/agrovoc/c_4073
http://aims.fao.org/aos/agrovoc/c_4540
Barros Santos, Millena
Barouh, Nathalie
Lullien-Pellerin, Valérie
Micard, Valérie
Villeneuve, Pierre
Zhou, Bingqing
Oger, Camille
Vigor, Claire
Durand, Thierry
Larraz Ferreira, Mariana Simões
Bourlieu-Lacanal, Claire
Ryan, Elizabeth P.
Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children
description Scope: The purpose of the study is to characterize the chemical diversity in Rice bran (RB) lipidome and determine whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children. Methods and Results: Untargeted and targeted lipidomics via ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) were applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose-USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome was conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention (15 g/d) with a control or RB supplemented snack. Untargeted lipidomic revealed 118 lipids as the core of lipidome across all 17 varieties among which phospholipids were abundant and oxylipins present. Phytoprostanes and phytofurans were quantified and characterized. Lipidome analysis of the children plasma following RB consumption revealed the presence of novel polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption. Conclusion: The investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health-promoting properties especially interesting for people at risk for cardiometabolic disease.
format article
topic_facet Q04 - Composition des produits alimentaires
S50 - Santé humaine
glycolipide
acide gras
métabolisme des lipides
métabolisme des phospholipides
lipide
enfant
phosphatide
son de riz
composition des aliments
http://aims.fao.org/aos/agrovoc/c_32670
http://aims.fao.org/aos/agrovoc/c_2818
http://aims.fao.org/aos/agrovoc/c_4361
http://aims.fao.org/aos/agrovoc/c_5802
http://aims.fao.org/aos/agrovoc/c_4362
http://aims.fao.org/aos/agrovoc/c_1547
http://aims.fao.org/aos/agrovoc/c_5803
http://aims.fao.org/aos/agrovoc/c_77d35680
http://aims.fao.org/aos/agrovoc/c_10961
http://aims.fao.org/aos/agrovoc/c_4073
http://aims.fao.org/aos/agrovoc/c_4540
author Barros Santos, Millena
Barouh, Nathalie
Lullien-Pellerin, Valérie
Micard, Valérie
Villeneuve, Pierre
Zhou, Bingqing
Oger, Camille
Vigor, Claire
Durand, Thierry
Larraz Ferreira, Mariana Simões
Bourlieu-Lacanal, Claire
Ryan, Elizabeth P.
author_facet Barros Santos, Millena
Barouh, Nathalie
Lullien-Pellerin, Valérie
Micard, Valérie
Villeneuve, Pierre
Zhou, Bingqing
Oger, Camille
Vigor, Claire
Durand, Thierry
Larraz Ferreira, Mariana Simões
Bourlieu-Lacanal, Claire
Ryan, Elizabeth P.
author_sort Barros Santos, Millena
title Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children
title_short Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children
title_full Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children
title_fullStr Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children
title_full_unstemmed Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children
title_sort rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children
url http://agritrop.cirad.fr/603134/
http://agritrop.cirad.fr/603134/13/603134ed.pdf
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