Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children
Scope: The purpose of the study is to characterize the chemical diversity in Rice bran (RB) lipidome and determine whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children. Methods and Results: Untargeted and targeted lipidomics via ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) were applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose-USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome was conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention (15 g/d) with a control or RB supplemented snack. Untargeted lipidomic revealed 118 lipids as the core of lipidome across all 17 varieties among which phospholipids were abundant and oxylipins present. Phytoprostanes and phytofurans were quantified and characterized. Lipidome analysis of the children plasma following RB consumption revealed the presence of novel polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption. Conclusion: The investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health-promoting properties especially interesting for people at risk for cardiometabolic disease.
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Format: | article biblioteca |
Language: | eng |
Subjects: | Q04 - Composition des produits alimentaires, S50 - Santé humaine, glycolipide, acide gras, métabolisme des lipides, métabolisme des phospholipides, lipide, enfant, phosphatide, son de riz, composition des aliments, http://aims.fao.org/aos/agrovoc/c_32670, http://aims.fao.org/aos/agrovoc/c_2818, http://aims.fao.org/aos/agrovoc/c_4361, http://aims.fao.org/aos/agrovoc/c_5802, http://aims.fao.org/aos/agrovoc/c_4362, http://aims.fao.org/aos/agrovoc/c_1547, http://aims.fao.org/aos/agrovoc/c_5803, http://aims.fao.org/aos/agrovoc/c_77d35680, http://aims.fao.org/aos/agrovoc/c_10961, http://aims.fao.org/aos/agrovoc/c_4073, http://aims.fao.org/aos/agrovoc/c_4540, |
Online Access: | http://agritrop.cirad.fr/603134/ http://agritrop.cirad.fr/603134/13/603134ed.pdf |
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dig-cirad-fr-6031342024-02-15T05:31:56Z http://agritrop.cirad.fr/603134/ http://agritrop.cirad.fr/603134/ Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children. Barros Santos Millena, Barouh Nathalie, Lullien-Pellerin Valérie, Micard Valérie, Villeneuve Pierre, Zhou Bingqing, Oger Camille, Vigor Claire, Durand Thierry, Larraz Ferreira Mariana Simões, Bourlieu-Lacanal Claire, Ryan Elizabeth P.. 2023. Molecular Nutrition and Food Research, 67 (6):2200111, 13 p.https://doi.org/10.1002/mnfr.202200111 <https://doi.org/10.1002/mnfr.202200111> Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children Barros Santos, Millena Barouh, Nathalie Lullien-Pellerin, Valérie Micard, Valérie Villeneuve, Pierre Zhou, Bingqing Oger, Camille Vigor, Claire Durand, Thierry Larraz Ferreira, Mariana Simões Bourlieu-Lacanal, Claire Ryan, Elizabeth P. eng 2023 Molecular Nutrition and Food Research Q04 - Composition des produits alimentaires S50 - Santé humaine glycolipide acide gras métabolisme des lipides métabolisme des phospholipides lipide enfant phosphatide son de riz composition des aliments http://aims.fao.org/aos/agrovoc/c_32670 http://aims.fao.org/aos/agrovoc/c_2818 http://aims.fao.org/aos/agrovoc/c_4361 http://aims.fao.org/aos/agrovoc/c_5802 http://aims.fao.org/aos/agrovoc/c_4362 http://aims.fao.org/aos/agrovoc/c_1547 http://aims.fao.org/aos/agrovoc/c_5803 http://aims.fao.org/aos/agrovoc/c_77d35680 http://aims.fao.org/aos/agrovoc/c_10961 Cambodge Mali http://aims.fao.org/aos/agrovoc/c_4073 http://aims.fao.org/aos/agrovoc/c_4540 Scope: The purpose of the study is to characterize the chemical diversity in Rice bran (RB) lipidome and determine whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children. Methods and Results: Untargeted and targeted lipidomics via ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) were applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose-USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome was conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention (15 g/d) with a control or RB supplemented snack. Untargeted lipidomic revealed 118 lipids as the core of lipidome across all 17 varieties among which phospholipids were abundant and oxylipins present. Phytoprostanes and phytofurans were quantified and characterized. Lipidome analysis of the children plasma following RB consumption revealed the presence of novel polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption. Conclusion: The investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health-promoting properties especially interesting for people at risk for cardiometabolic disease. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/603134/13/603134ed.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.1002/mnfr.202200111 10.1002/mnfr.202200111 info:eu-repo/semantics/altIdentifier/doi/10.1002/mnfr.202200111 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1002/mnfr.202200111 info:eu-repo/grantAgreement///2016-67001-24538//(USA) Rice bran and bean metabolomes for human dietary exposure biomarkers/ |
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Q04 - Composition des produits alimentaires S50 - Santé humaine glycolipide acide gras métabolisme des lipides métabolisme des phospholipides lipide enfant phosphatide son de riz composition des aliments http://aims.fao.org/aos/agrovoc/c_32670 http://aims.fao.org/aos/agrovoc/c_2818 http://aims.fao.org/aos/agrovoc/c_4361 http://aims.fao.org/aos/agrovoc/c_5802 http://aims.fao.org/aos/agrovoc/c_4362 http://aims.fao.org/aos/agrovoc/c_1547 http://aims.fao.org/aos/agrovoc/c_5803 http://aims.fao.org/aos/agrovoc/c_77d35680 http://aims.fao.org/aos/agrovoc/c_10961 http://aims.fao.org/aos/agrovoc/c_4073 http://aims.fao.org/aos/agrovoc/c_4540 Q04 - Composition des produits alimentaires S50 - Santé humaine glycolipide acide gras métabolisme des lipides métabolisme des phospholipides lipide enfant phosphatide son de riz composition des aliments http://aims.fao.org/aos/agrovoc/c_32670 http://aims.fao.org/aos/agrovoc/c_2818 http://aims.fao.org/aos/agrovoc/c_4361 http://aims.fao.org/aos/agrovoc/c_5802 http://aims.fao.org/aos/agrovoc/c_4362 http://aims.fao.org/aos/agrovoc/c_1547 http://aims.fao.org/aos/agrovoc/c_5803 http://aims.fao.org/aos/agrovoc/c_77d35680 http://aims.fao.org/aos/agrovoc/c_10961 http://aims.fao.org/aos/agrovoc/c_4073 http://aims.fao.org/aos/agrovoc/c_4540 |
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Q04 - Composition des produits alimentaires S50 - Santé humaine glycolipide acide gras métabolisme des lipides métabolisme des phospholipides lipide enfant phosphatide son de riz composition des aliments http://aims.fao.org/aos/agrovoc/c_32670 http://aims.fao.org/aos/agrovoc/c_2818 http://aims.fao.org/aos/agrovoc/c_4361 http://aims.fao.org/aos/agrovoc/c_5802 http://aims.fao.org/aos/agrovoc/c_4362 http://aims.fao.org/aos/agrovoc/c_1547 http://aims.fao.org/aos/agrovoc/c_5803 http://aims.fao.org/aos/agrovoc/c_77d35680 http://aims.fao.org/aos/agrovoc/c_10961 http://aims.fao.org/aos/agrovoc/c_4073 http://aims.fao.org/aos/agrovoc/c_4540 Q04 - Composition des produits alimentaires S50 - Santé humaine glycolipide acide gras métabolisme des lipides métabolisme des phospholipides lipide enfant phosphatide son de riz composition des aliments http://aims.fao.org/aos/agrovoc/c_32670 http://aims.fao.org/aos/agrovoc/c_2818 http://aims.fao.org/aos/agrovoc/c_4361 http://aims.fao.org/aos/agrovoc/c_5802 http://aims.fao.org/aos/agrovoc/c_4362 http://aims.fao.org/aos/agrovoc/c_1547 http://aims.fao.org/aos/agrovoc/c_5803 http://aims.fao.org/aos/agrovoc/c_77d35680 http://aims.fao.org/aos/agrovoc/c_10961 http://aims.fao.org/aos/agrovoc/c_4073 http://aims.fao.org/aos/agrovoc/c_4540 Barros Santos, Millena Barouh, Nathalie Lullien-Pellerin, Valérie Micard, Valérie Villeneuve, Pierre Zhou, Bingqing Oger, Camille Vigor, Claire Durand, Thierry Larraz Ferreira, Mariana Simões Bourlieu-Lacanal, Claire Ryan, Elizabeth P. Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children |
description |
Scope: The purpose of the study is to characterize the chemical diversity in Rice bran (RB) lipidome and determine whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children. Methods and Results: Untargeted and targeted lipidomics via ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) were applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose-USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome was conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention (15 g/d) with a control or RB supplemented snack. Untargeted lipidomic revealed 118 lipids as the core of lipidome across all 17 varieties among which phospholipids were abundant and oxylipins present. Phytoprostanes and phytofurans were quantified and characterized. Lipidome analysis of the children plasma following RB consumption revealed the presence of novel polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption. Conclusion: The investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health-promoting properties especially interesting for people at risk for cardiometabolic disease. |
format |
article |
topic_facet |
Q04 - Composition des produits alimentaires S50 - Santé humaine glycolipide acide gras métabolisme des lipides métabolisme des phospholipides lipide enfant phosphatide son de riz composition des aliments http://aims.fao.org/aos/agrovoc/c_32670 http://aims.fao.org/aos/agrovoc/c_2818 http://aims.fao.org/aos/agrovoc/c_4361 http://aims.fao.org/aos/agrovoc/c_5802 http://aims.fao.org/aos/agrovoc/c_4362 http://aims.fao.org/aos/agrovoc/c_1547 http://aims.fao.org/aos/agrovoc/c_5803 http://aims.fao.org/aos/agrovoc/c_77d35680 http://aims.fao.org/aos/agrovoc/c_10961 http://aims.fao.org/aos/agrovoc/c_4073 http://aims.fao.org/aos/agrovoc/c_4540 |
author |
Barros Santos, Millena Barouh, Nathalie Lullien-Pellerin, Valérie Micard, Valérie Villeneuve, Pierre Zhou, Bingqing Oger, Camille Vigor, Claire Durand, Thierry Larraz Ferreira, Mariana Simões Bourlieu-Lacanal, Claire Ryan, Elizabeth P. |
author_facet |
Barros Santos, Millena Barouh, Nathalie Lullien-Pellerin, Valérie Micard, Valérie Villeneuve, Pierre Zhou, Bingqing Oger, Camille Vigor, Claire Durand, Thierry Larraz Ferreira, Mariana Simões Bourlieu-Lacanal, Claire Ryan, Elizabeth P. |
author_sort |
Barros Santos, Millena |
title |
Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children |
title_short |
Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children |
title_full |
Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children |
title_fullStr |
Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children |
title_full_unstemmed |
Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children |
title_sort |
rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children |
url |
http://agritrop.cirad.fr/603134/ http://agritrop.cirad.fr/603134/13/603134ed.pdf |
work_keys_str_mv |
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