Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China
Background: Aedes albopictus is a public health threat for its worldwide spread and ability to transmit arboviruses. Understanding mechanisms of mosquito immunity can provide new tools to control arbovirus spread. The genomes of Aedes mosquitoes contain hundreds of nonretroviral endogenous viral elements (nrEVEs), which are enriched in piRNA clusters and produce piRNAs, with the potential to target cognate viruses. Recently, one nrEVE was shown to limit cognate viral infection through nrEVE-derived piRNAs. These findings suggest that nrEVEs constitute an archive of past viral infection and that the landscape of viral integrations may be variable across populations depending on their viral exposure. Methods: We used bioinformatics and molecular approaches to identify known and novel (i.e. absent in the reference genome) viral integrations in the genome of wild collected Aedes albopictus mosquitoes and characterize their virome. Results: We showed that the landscape of viral integrations is dynamic with seven novel viral integrations being characterized, but does not correlate with the virome, which includes both viral species known and unknown to infect mosquitoes. However, the small RNA coverage profile of nrEVEs and the viral genomic contigs we identified confirmed an interaction among these elements and the piRNA and siRNA pathways in mosquitoes. Conclusions: Mosquitoes nrEVEs have been recently described as a new form of heritable, sequence-specific mechanism of antiviral immunity. Our results contribute to understanding the dynamic distribution of nrEVEs in the genomes of wild Ae. albopictus and their interaction with mosquito viruses.
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Subjects: | L72 - Organismes nuisibles des animaux, L73 - Maladies des animaux, S50 - Santé humaine, L10 - Génétique et amélioration des animaux, virologie, vecteur de maladie, transmission des maladies, Aedes albopictus, http://aims.fao.org/aos/agrovoc/c_8259, http://aims.fao.org/aos/agrovoc/c_8164, http://aims.fao.org/aos/agrovoc/c_2329, http://aims.fao.org/aos/agrovoc/c_30483, http://aims.fao.org/aos/agrovoc/c_6543, http://aims.fao.org/aos/agrovoc/c_3081, http://aims.fao.org/aos/agrovoc/c_1556, |
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dig-cirad-fr-6028452024-01-29T19:01:26Z http://agritrop.cirad.fr/602845/ http://agritrop.cirad.fr/602845/ Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China. Palatini Umberto, Alfano Niccolo, Lejarazu Carballar Rebeca, Chen Xiao-Guang, Delatte Hélène, Bonizzoni Mariangela. 2022. Virology Journal, 19:190, 12 p.https://doi.org/10.1186/s12985-022-01918-8 <https://doi.org/10.1186/s12985-022-01918-8> Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China Palatini, Umberto Alfano, Niccolo Lejarazu Carballar, Rebeca Chen, Xiao-Guang Delatte, Hélène Bonizzoni, Mariangela eng 2022 Virology Journal L72 - Organismes nuisibles des animaux L73 - Maladies des animaux S50 - Santé humaine L10 - Génétique et amélioration des animaux virologie vecteur de maladie transmission des maladies Aedes albopictus http://aims.fao.org/aos/agrovoc/c_8259 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_30483 La Réunion France Chine http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 http://aims.fao.org/aos/agrovoc/c_1556 Background: Aedes albopictus is a public health threat for its worldwide spread and ability to transmit arboviruses. Understanding mechanisms of mosquito immunity can provide new tools to control arbovirus spread. The genomes of Aedes mosquitoes contain hundreds of nonretroviral endogenous viral elements (nrEVEs), which are enriched in piRNA clusters and produce piRNAs, with the potential to target cognate viruses. Recently, one nrEVE was shown to limit cognate viral infection through nrEVE-derived piRNAs. These findings suggest that nrEVEs constitute an archive of past viral infection and that the landscape of viral integrations may be variable across populations depending on their viral exposure. Methods: We used bioinformatics and molecular approaches to identify known and novel (i.e. absent in the reference genome) viral integrations in the genome of wild collected Aedes albopictus mosquitoes and characterize their virome. Results: We showed that the landscape of viral integrations is dynamic with seven novel viral integrations being characterized, but does not correlate with the virome, which includes both viral species known and unknown to infect mosquitoes. However, the small RNA coverage profile of nrEVEs and the viral genomic contigs we identified confirmed an interaction among these elements and the piRNA and siRNA pathways in mosquitoes. Conclusions: Mosquitoes nrEVEs have been recently described as a new form of heritable, sequence-specific mechanism of antiviral immunity. Our results contribute to understanding the dynamic distribution of nrEVEs in the genomes of wild Ae. albopictus and their interaction with mosquito viruses. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/602845/7/602845.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.1186/s12985-022-01918-8 10.1186/s12985-022-01918-8 info:eu-repo/semantics/altIdentifier/doi/10.1186/s12985-022-01918-8 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1186/s12985-022-01918-8 |
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L72 - Organismes nuisibles des animaux L73 - Maladies des animaux S50 - Santé humaine L10 - Génétique et amélioration des animaux virologie vecteur de maladie transmission des maladies Aedes albopictus http://aims.fao.org/aos/agrovoc/c_8259 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_30483 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 http://aims.fao.org/aos/agrovoc/c_1556 L72 - Organismes nuisibles des animaux L73 - Maladies des animaux S50 - Santé humaine L10 - Génétique et amélioration des animaux virologie vecteur de maladie transmission des maladies Aedes albopictus http://aims.fao.org/aos/agrovoc/c_8259 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_30483 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 http://aims.fao.org/aos/agrovoc/c_1556 |
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L72 - Organismes nuisibles des animaux L73 - Maladies des animaux S50 - Santé humaine L10 - Génétique et amélioration des animaux virologie vecteur de maladie transmission des maladies Aedes albopictus http://aims.fao.org/aos/agrovoc/c_8259 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_30483 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 http://aims.fao.org/aos/agrovoc/c_1556 L72 - Organismes nuisibles des animaux L73 - Maladies des animaux S50 - Santé humaine L10 - Génétique et amélioration des animaux virologie vecteur de maladie transmission des maladies Aedes albopictus http://aims.fao.org/aos/agrovoc/c_8259 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_30483 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 http://aims.fao.org/aos/agrovoc/c_1556 Palatini, Umberto Alfano, Niccolo Lejarazu Carballar, Rebeca Chen, Xiao-Guang Delatte, Hélène Bonizzoni, Mariangela Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China |
description |
Background: Aedes albopictus is a public health threat for its worldwide spread and ability to transmit arboviruses. Understanding mechanisms of mosquito immunity can provide new tools to control arbovirus spread. The genomes of Aedes mosquitoes contain hundreds of nonretroviral endogenous viral elements (nrEVEs), which are enriched in piRNA clusters and produce piRNAs, with the potential to target cognate viruses. Recently, one nrEVE was shown to limit cognate viral infection through nrEVE-derived piRNAs. These findings suggest that nrEVEs constitute an archive of past viral infection and that the landscape of viral integrations may be variable across populations depending on their viral exposure. Methods: We used bioinformatics and molecular approaches to identify known and novel (i.e. absent in the reference genome) viral integrations in the genome of wild collected Aedes albopictus mosquitoes and characterize their virome. Results: We showed that the landscape of viral integrations is dynamic with seven novel viral integrations being characterized, but does not correlate with the virome, which includes both viral species known and unknown to infect mosquitoes. However, the small RNA coverage profile of nrEVEs and the viral genomic contigs we identified confirmed an interaction among these elements and the piRNA and siRNA pathways in mosquitoes. Conclusions: Mosquitoes nrEVEs have been recently described as a new form of heritable, sequence-specific mechanism of antiviral immunity. Our results contribute to understanding the dynamic distribution of nrEVEs in the genomes of wild Ae. albopictus and their interaction with mosquito viruses. |
format |
article |
topic_facet |
L72 - Organismes nuisibles des animaux L73 - Maladies des animaux S50 - Santé humaine L10 - Génétique et amélioration des animaux virologie vecteur de maladie transmission des maladies Aedes albopictus http://aims.fao.org/aos/agrovoc/c_8259 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_30483 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 http://aims.fao.org/aos/agrovoc/c_1556 |
author |
Palatini, Umberto Alfano, Niccolo Lejarazu Carballar, Rebeca Chen, Xiao-Guang Delatte, Hélène Bonizzoni, Mariangela |
author_facet |
Palatini, Umberto Alfano, Niccolo Lejarazu Carballar, Rebeca Chen, Xiao-Guang Delatte, Hélène Bonizzoni, Mariangela |
author_sort |
Palatini, Umberto |
title |
Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China |
title_short |
Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China |
title_full |
Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China |
title_fullStr |
Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China |
title_full_unstemmed |
Virome and nrEVEome diversity of Aedes albopictus mosquitoes from La Reunion Island and China |
title_sort |
virome and nreveome diversity of aedes albopictus mosquitoes from la reunion island and china |
url |
http://agritrop.cirad.fr/602845/ http://agritrop.cirad.fr/602845/7/602845.pdf |
work_keys_str_mv |
AT palatiniumberto viromeandnreveomediversityofaedesalbopictusmosquitoesfromlareunionislandandchina AT alfanoniccolo viromeandnreveomediversityofaedesalbopictusmosquitoesfromlareunionislandandchina AT lejarazucarballarrebeca viromeandnreveomediversityofaedesalbopictusmosquitoesfromlareunionislandandchina AT chenxiaoguang viromeandnreveomediversityofaedesalbopictusmosquitoesfromlareunionislandandchina AT delattehelene viromeandnreveomediversityofaedesalbopictusmosquitoesfromlareunionislandandchina AT bonizzonimariangela viromeandnreveomediversityofaedesalbopictusmosquitoesfromlareunionislandandchina |
_version_ |
1792500443707867136 |