Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe
Crimean–Congo hemorrhagic fever (CCHF) is a viral zoonotic disease resulting in hemorrhagic syndrome in humans. Its causative agent is naturally transmitted by ticks to non-human vertebrate hosts within an enzootic sylvatic cycle. Ticks are considered biological vectors, as well as reservoirs for CCHF virus (CCHFV), as they are able to maintain the virus for several months or even years and to transmit CCHFV to other ticks. Although animals are not symptomatic, some of them can sufficiently replicate the virus, becoming a source of infection for ticks as well as humans through direct contact with contaminated body fluids. The recent emergence of CCHF in Spain indicates that tick–human interaction rates promoting virus transmission are changing and lead to the emergence of CCHF. In other European countries such as France, the presence of one of its main tick vectors and the detection of antibodies targeting CCHFV in animals, at least in Corsica and in the absence of human cases, suggest that CCHFV could be spreading silently. In this review, we study the CCHFV epidemiological cycle as hypothesized in the French local context and select the most likely parameters that may influence virus transmission among tick vectors and non-human vertebrate hosts. For this, a total of 1,035 articles dating from 1957 to 2021 were selected for data extraction. This study made it possible to identify the tick species that seem to be the best candidate vectors of CCHFV in France, but also to highlight the importance of the abundance and composition of local host communities on vectors' infection prevalence. Regarding the presumed transmission cycle involving Hyalomma marginatum, as it might exist in France, at least in Corsica, it is assumed that tick vectors are still weakly infected and the probability of disease emergence in humans remains low. The likelihood of factors that may modify this equilibrium is discussed.
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Format: | article biblioteca |
Language: | eng |
Subjects: | L73 - Maladies des animaux, S50 - Santé humaine, L72 - Organismes nuisibles des animaux, fièvre hémorragique de Crimée-Congo, maladie transmissible par tiques, zoonose, vecteur de maladie, surveillance épidémiologique, transmission des maladies, maladie de l'homme, http://aims.fao.org/aos/agrovoc/c_ac826b92, http://aims.fao.org/aos/agrovoc/c_24908, http://aims.fao.org/aos/agrovoc/c_8530, http://aims.fao.org/aos/agrovoc/c_8164, http://aims.fao.org/aos/agrovoc/c_16411, http://aims.fao.org/aos/agrovoc/c_2329, http://aims.fao.org/aos/agrovoc/c_29198, http://aims.fao.org/aos/agrovoc/c_3081, |
Online Access: | http://agritrop.cirad.fr/601839/ http://agritrop.cirad.fr/601839/1/fvets-09-932304.pdf |
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dig-cirad-fr-6018392024-01-29T19:05:49Z http://agritrop.cirad.fr/601839/ http://agritrop.cirad.fr/601839/ Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe. Bernard Célia, Holzmuller Philippe, Bah Madiou Thierno, Bastien Matthieu, Combes Benoit, Jori Ferran, Grosbois Vladimir, Vial Laurence. 2022. Frontiers in Veterinary Science, 9:932304, 17 p.https://doi.org/10.3389/fvets.2022.932304 <https://doi.org/10.3389/fvets.2022.932304> Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe Bernard, Célia Holzmuller, Philippe Bah, Madiou Thierno Bastien, Matthieu Combes, Benoit Jori, Ferran Grosbois, Vladimir Vial, Laurence eng 2022 Frontiers in Veterinary Science L73 - Maladies des animaux S50 - Santé humaine L72 - Organismes nuisibles des animaux fièvre hémorragique de Crimée-Congo maladie transmissible par tiques zoonose vecteur de maladie surveillance épidémiologique transmission des maladies maladie de l'homme http://aims.fao.org/aos/agrovoc/c_ac826b92 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_29198 France http://aims.fao.org/aos/agrovoc/c_3081 Crimean–Congo hemorrhagic fever (CCHF) is a viral zoonotic disease resulting in hemorrhagic syndrome in humans. Its causative agent is naturally transmitted by ticks to non-human vertebrate hosts within an enzootic sylvatic cycle. Ticks are considered biological vectors, as well as reservoirs for CCHF virus (CCHFV), as they are able to maintain the virus for several months or even years and to transmit CCHFV to other ticks. Although animals are not symptomatic, some of them can sufficiently replicate the virus, becoming a source of infection for ticks as well as humans through direct contact with contaminated body fluids. The recent emergence of CCHF in Spain indicates that tick–human interaction rates promoting virus transmission are changing and lead to the emergence of CCHF. In other European countries such as France, the presence of one of its main tick vectors and the detection of antibodies targeting CCHFV in animals, at least in Corsica and in the absence of human cases, suggest that CCHFV could be spreading silently. In this review, we study the CCHFV epidemiological cycle as hypothesized in the French local context and select the most likely parameters that may influence virus transmission among tick vectors and non-human vertebrate hosts. For this, a total of 1,035 articles dating from 1957 to 2021 were selected for data extraction. This study made it possible to identify the tick species that seem to be the best candidate vectors of CCHFV in France, but also to highlight the importance of the abundance and composition of local host communities on vectors' infection prevalence. Regarding the presumed transmission cycle involving Hyalomma marginatum, as it might exist in France, at least in Corsica, it is assumed that tick vectors are still weakly infected and the probability of disease emergence in humans remains low. The likelihood of factors that may modify this equilibrium is discussed. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/601839/1/fvets-09-932304.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.3389/fvets.2022.932304 10.3389/fvets.2022.932304 info:eu-repo/semantics/altIdentifier/doi/10.3389/fvets.2022.932304 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.3389/fvets.2022.932304 |
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L73 - Maladies des animaux S50 - Santé humaine L72 - Organismes nuisibles des animaux fièvre hémorragique de Crimée-Congo maladie transmissible par tiques zoonose vecteur de maladie surveillance épidémiologique transmission des maladies maladie de l'homme http://aims.fao.org/aos/agrovoc/c_ac826b92 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_3081 L73 - Maladies des animaux S50 - Santé humaine L72 - Organismes nuisibles des animaux fièvre hémorragique de Crimée-Congo maladie transmissible par tiques zoonose vecteur de maladie surveillance épidémiologique transmission des maladies maladie de l'homme http://aims.fao.org/aos/agrovoc/c_ac826b92 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_3081 |
spellingShingle |
L73 - Maladies des animaux S50 - Santé humaine L72 - Organismes nuisibles des animaux fièvre hémorragique de Crimée-Congo maladie transmissible par tiques zoonose vecteur de maladie surveillance épidémiologique transmission des maladies maladie de l'homme http://aims.fao.org/aos/agrovoc/c_ac826b92 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_3081 L73 - Maladies des animaux S50 - Santé humaine L72 - Organismes nuisibles des animaux fièvre hémorragique de Crimée-Congo maladie transmissible par tiques zoonose vecteur de maladie surveillance épidémiologique transmission des maladies maladie de l'homme http://aims.fao.org/aos/agrovoc/c_ac826b92 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_3081 Bernard, Célia Holzmuller, Philippe Bah, Madiou Thierno Bastien, Matthieu Combes, Benoit Jori, Ferran Grosbois, Vladimir Vial, Laurence Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe |
description |
Crimean–Congo hemorrhagic fever (CCHF) is a viral zoonotic disease resulting in hemorrhagic syndrome in humans. Its causative agent is naturally transmitted by ticks to non-human vertebrate hosts within an enzootic sylvatic cycle. Ticks are considered biological vectors, as well as reservoirs for CCHF virus (CCHFV), as they are able to maintain the virus for several months or even years and to transmit CCHFV to other ticks. Although animals are not symptomatic, some of them can sufficiently replicate the virus, becoming a source of infection for ticks as well as humans through direct contact with contaminated body fluids. The recent emergence of CCHF in Spain indicates that tick–human interaction rates promoting virus transmission are changing and lead to the emergence of CCHF. In other European countries such as France, the presence of one of its main tick vectors and the detection of antibodies targeting CCHFV in animals, at least in Corsica and in the absence of human cases, suggest that CCHFV could be spreading silently. In this review, we study the CCHFV epidemiological cycle as hypothesized in the French local context and select the most likely parameters that may influence virus transmission among tick vectors and non-human vertebrate hosts. For this, a total of 1,035 articles dating from 1957 to 2021 were selected for data extraction. This study made it possible to identify the tick species that seem to be the best candidate vectors of CCHFV in France, but also to highlight the importance of the abundance and composition of local host communities on vectors' infection prevalence. Regarding the presumed transmission cycle involving Hyalomma marginatum, as it might exist in France, at least in Corsica, it is assumed that tick vectors are still weakly infected and the probability of disease emergence in humans remains low. The likelihood of factors that may modify this equilibrium is discussed. |
format |
article |
topic_facet |
L73 - Maladies des animaux S50 - Santé humaine L72 - Organismes nuisibles des animaux fièvre hémorragique de Crimée-Congo maladie transmissible par tiques zoonose vecteur de maladie surveillance épidémiologique transmission des maladies maladie de l'homme http://aims.fao.org/aos/agrovoc/c_ac826b92 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_3081 |
author |
Bernard, Célia Holzmuller, Philippe Bah, Madiou Thierno Bastien, Matthieu Combes, Benoit Jori, Ferran Grosbois, Vladimir Vial, Laurence |
author_facet |
Bernard, Célia Holzmuller, Philippe Bah, Madiou Thierno Bastien, Matthieu Combes, Benoit Jori, Ferran Grosbois, Vladimir Vial, Laurence |
author_sort |
Bernard, Célia |
title |
Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe |
title_short |
Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe |
title_full |
Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe |
title_fullStr |
Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe |
title_full_unstemmed |
Systematic review on Crimean–Congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: Special focus on France, an apparently free-disease area in Europe |
title_sort |
systematic review on crimean–congo hemorrhagic fever enzootic cycle and factors favoring virus transmission: special focus on france, an apparently free-disease area in europe |
url |
http://agritrop.cirad.fr/601839/ http://agritrop.cirad.fr/601839/1/fvets-09-932304.pdf |
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