Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity
Wolbachia-based biological control has recently emerged as an ecologically friendly and potentially cost-effective method for prevention and control of dengue and other arboviral infections. When deliberately infected withWolbachia, major vector species, such as Aedes aegypti females, lose their vectorial competence and become less capable of transmitting the virus to humans. Thus, Wolbachia-based biocontrol aims to replace wild vectors (fully capa- ble of transmitting arboviral infections) by Wolbachia-carrying insects that bear a reduced transmission capacity. The population replacement can be achieved by releasing mosquitoes that were transinfected with Wolbachia during the process of mass-rearing. In this presentation, we propose a sex-structured model describing the dynamics of two sup-populations of adult mosquitoes: the wild insects (males and females that are Wolbachia- free), and those deliberately infected with Wolbachia. This model is biologically viable, well-posed, and reflects the two significant features of Wolbachia: maternal transmission and cytoplasmic incompatibility. The model also exhibits bistability that agrees with the principle of competitive exclusion. Using this mosquito population dynamics model, we further construct a dengue transmis- sion system of SEIR-SEI type to perform an epidemiological assessment of Wolbachia-based control for prevention of dengue morbidity. As an example, we simulate this type of preven- tive control applied to Cali, a sizeable Colombian city commonly considered a hyperendemic area regarding dengue morbidity.
Main Authors: | , , , , |
---|---|
Format: | conference_item biblioteca |
Language: | eng |
Published: |
Virginia Commonwealth University
|
Online Access: | http://agritrop.cirad.fr/601107/ http://agritrop.cirad.fr/601107/1/Epidemiological%20assessment%20of%20Wolbachia-based%20biocontrol_conference_2022.pdf |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-cirad-fr-601107 |
---|---|
record_format |
koha |
spelling |
dig-cirad-fr-6011072022-07-05T16:49:36Z http://agritrop.cirad.fr/601107/ http://agritrop.cirad.fr/601107/ Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity. Vasilieva Olga, Escobar Oscar, Martinez Hector, Bliman Pierre-Alexandre, Dumont Yves. 2022. . VCU. Richmond : Virginia Commonwealth University, Résumé, 3 p. Biology and Medicine Through Mathematics Conference, Richmond, États-Unis, 18 Mai 2022/20 Mai 2022.https://scholarscompass.vcu.edu/bamm/2022/fri/6/ <https://scholarscompass.vcu.edu/bamm/2022/fri/6/> Researchers Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity Vasilieva, Olga Escobar, Oscar Martinez, Hector Bliman, Pierre-Alexandre Dumont, Yves eng 2022 Virginia Commonwealth University Wolbachia-based biological control has recently emerged as an ecologically friendly and potentially cost-effective method for prevention and control of dengue and other arboviral infections. When deliberately infected withWolbachia, major vector species, such as Aedes aegypti females, lose their vectorial competence and become less capable of transmitting the virus to humans. Thus, Wolbachia-based biocontrol aims to replace wild vectors (fully capa- ble of transmitting arboviral infections) by Wolbachia-carrying insects that bear a reduced transmission capacity. The population replacement can be achieved by releasing mosquitoes that were transinfected with Wolbachia during the process of mass-rearing. In this presentation, we propose a sex-structured model describing the dynamics of two sup-populations of adult mosquitoes: the wild insects (males and females that are Wolbachia- free), and those deliberately infected with Wolbachia. This model is biologically viable, well-posed, and reflects the two significant features of Wolbachia: maternal transmission and cytoplasmic incompatibility. The model also exhibits bistability that agrees with the principle of competitive exclusion. Using this mosquito population dynamics model, we further construct a dengue transmis- sion system of SEIR-SEI type to perform an epidemiological assessment of Wolbachia-based control for prevention of dengue morbidity. As an example, we simulate this type of preven- tive control applied to Cali, a sizeable Colombian city commonly considered a hyperendemic area regarding dengue morbidity. conference_item info:eu-repo/semantics/conferenceObject Conference info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/601107/1/Epidemiological%20assessment%20of%20Wolbachia-based%20biocontrol_conference_2022.pdf text Cirad license info:eu-repo/semantics/openAccess https://agritrop.cirad.fr/mention_legale.html https://scholarscompass.vcu.edu/bamm/2022/fri/6/ info:eu-repo/semantics/altIdentifier/purl/https://scholarscompass.vcu.edu/bamm/2022/fri/6/ |
institution |
CIRAD FR |
collection |
DSpace |
country |
Francia |
countrycode |
FR |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-cirad-fr |
tag |
biblioteca |
region |
Europa del Oeste |
libraryname |
Biblioteca del CIRAD Francia |
language |
eng |
description |
Wolbachia-based biological control has recently emerged as an ecologically friendly and potentially cost-effective method for prevention and control of dengue and other arboviral infections. When deliberately infected withWolbachia, major vector species, such as Aedes aegypti females, lose their vectorial competence and become less capable of transmitting the virus to humans. Thus, Wolbachia-based biocontrol aims to replace wild vectors (fully capa- ble of transmitting arboviral infections) by Wolbachia-carrying insects that bear a reduced transmission capacity. The population replacement can be achieved by releasing mosquitoes that were transinfected with Wolbachia during the process of mass-rearing. In this presentation, we propose a sex-structured model describing the dynamics of two sup-populations of adult mosquitoes: the wild insects (males and females that are Wolbachia- free), and those deliberately infected with Wolbachia. This model is biologically viable, well-posed, and reflects the two significant features of Wolbachia: maternal transmission and cytoplasmic incompatibility. The model also exhibits bistability that agrees with the principle of competitive exclusion. Using this mosquito population dynamics model, we further construct a dengue transmis- sion system of SEIR-SEI type to perform an epidemiological assessment of Wolbachia-based control for prevention of dengue morbidity. As an example, we simulate this type of preven- tive control applied to Cali, a sizeable Colombian city commonly considered a hyperendemic area regarding dengue morbidity. |
format |
conference_item |
author |
Vasilieva, Olga Escobar, Oscar Martinez, Hector Bliman, Pierre-Alexandre Dumont, Yves |
spellingShingle |
Vasilieva, Olga Escobar, Oscar Martinez, Hector Bliman, Pierre-Alexandre Dumont, Yves Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity |
author_facet |
Vasilieva, Olga Escobar, Oscar Martinez, Hector Bliman, Pierre-Alexandre Dumont, Yves |
author_sort |
Vasilieva, Olga |
title |
Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity |
title_short |
Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity |
title_full |
Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity |
title_fullStr |
Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity |
title_full_unstemmed |
Epidemiological assessment of Wolbachia-based biocontrol for reduction of dengue morbidity |
title_sort |
epidemiological assessment of wolbachia-based biocontrol for reduction of dengue morbidity |
publisher |
Virginia Commonwealth University |
url |
http://agritrop.cirad.fr/601107/ http://agritrop.cirad.fr/601107/1/Epidemiological%20assessment%20of%20Wolbachia-based%20biocontrol_conference_2022.pdf |
work_keys_str_mv |
AT vasilievaolga epidemiologicalassessmentofwolbachiabasedbiocontrolforreductionofdenguemorbidity AT escobaroscar epidemiologicalassessmentofwolbachiabasedbiocontrolforreductionofdenguemorbidity AT martinezhector epidemiologicalassessmentofwolbachiabasedbiocontrolforreductionofdenguemorbidity AT blimanpierrealexandre epidemiologicalassessmentofwolbachiabasedbiocontrolforreductionofdenguemorbidity AT dumontyves epidemiologicalassessmentofwolbachiabasedbiocontrolforreductionofdenguemorbidity |
_version_ |
1758027102998757376 |