Nonribosomal peptide synthesis definitely working out of the rules
Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields. They are built up by huge multimodular enzymes called nonribosomal peptide synthetases. These synthetases are organized in modules constituted of adenylation, thiolation, and condensation core domains. As such, each module governs, according to the collinearity rule, the incorporation of a monomer within the growing peptide. The release of the peptide from the assembly chain is finally performed by a terminal core thioesterase domain. Secondary domains with modifying catalytic activities such as epimerization or methylation are sometimes included in the assembly lines as supplementary domains. This assembly line structure is analyzed by bioinformatics tools to predict the sequence and structure of the final peptides according to the sequence of the corresponding synthetases. However, a constantly expanding literature unravels new examples of nonribosomal synthetases exhibiting very rare domains and noncanonical organizations of domains and modules, leading to several amazing strategies developed by microorganisms to synthesize nonribosomal peptides. In this review, through several examples, we aim at highlighting these noncanonical pathways in order for the readers to perceive their complexity.
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Subjects: | F60 - Physiologie et biochimie végétale, C30 - Documentation et information, peptide synthetase, peptide, polypeptide, biosynthèse, métabolite secondaire, bioinformatique, technique de prévision, synthèse, bibliographie, http://aims.fao.org/aos/agrovoc/c_13231, http://aims.fao.org/aos/agrovoc/c_5691, http://aims.fao.org/aos/agrovoc/c_27801, http://aims.fao.org/aos/agrovoc/c_928, http://aims.fao.org/aos/agrovoc/c_34335, http://aims.fao.org/aos/agrovoc/c_37958, http://aims.fao.org/aos/agrovoc/c_3041, http://aims.fao.org/aos/agrovoc/c_3def4163, http://aims.fao.org/aos/agrovoc/c_1335513885866, |
Online Access: | http://agritrop.cirad.fr/600447/ http://agritrop.cirad.fr/600447/1/microorganisms-10-00577.pdf |
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dig-cirad-fr-6004472024-01-29T19:06:14Z http://agritrop.cirad.fr/600447/ http://agritrop.cirad.fr/600447/ Nonribosomal peptide synthesis definitely working out of the rules. Duban Matthieu, Cociancich Stéphane, Leclère Valérie. 2022. Microorganisms, 10 (3), n.spéc. Microbial Non-Ribosomal Synthesis of Secondary Metabolites:577, 19 p.https://doi.org/10.3390/microorganisms10030577 <https://doi.org/10.3390/microorganisms10030577> Nonribosomal peptide synthesis definitely working out of the rules Duban, Matthieu Cociancich, Stéphane Leclère, Valérie eng 2022 Microorganisms F60 - Physiologie et biochimie végétale C30 - Documentation et information peptide synthetase peptide polypeptide biosynthèse métabolite secondaire bioinformatique technique de prévision synthèse bibliographie http://aims.fao.org/aos/agrovoc/c_13231 http://aims.fao.org/aos/agrovoc/c_5691 http://aims.fao.org/aos/agrovoc/c_27801 http://aims.fao.org/aos/agrovoc/c_928 http://aims.fao.org/aos/agrovoc/c_34335 http://aims.fao.org/aos/agrovoc/c_37958 http://aims.fao.org/aos/agrovoc/c_3041 http://aims.fao.org/aos/agrovoc/c_3def4163 http://aims.fao.org/aos/agrovoc/c_1335513885866 Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields. They are built up by huge multimodular enzymes called nonribosomal peptide synthetases. These synthetases are organized in modules constituted of adenylation, thiolation, and condensation core domains. As such, each module governs, according to the collinearity rule, the incorporation of a monomer within the growing peptide. The release of the peptide from the assembly chain is finally performed by a terminal core thioesterase domain. Secondary domains with modifying catalytic activities such as epimerization or methylation are sometimes included in the assembly lines as supplementary domains. This assembly line structure is analyzed by bioinformatics tools to predict the sequence and structure of the final peptides according to the sequence of the corresponding synthetases. However, a constantly expanding literature unravels new examples of nonribosomal synthetases exhibiting very rare domains and noncanonical organizations of domains and modules, leading to several amazing strategies developed by microorganisms to synthesize nonribosomal peptides. In this review, through several examples, we aim at highlighting these noncanonical pathways in order for the readers to perceive their complexity. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/600447/1/microorganisms-10-00577.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.3390/microorganisms10030577 10.3390/microorganisms10030577 info:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms10030577 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.3390/microorganisms10030577 |
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F60 - Physiologie et biochimie végétale C30 - Documentation et information peptide synthetase peptide polypeptide biosynthèse métabolite secondaire bioinformatique technique de prévision synthèse bibliographie http://aims.fao.org/aos/agrovoc/c_13231 http://aims.fao.org/aos/agrovoc/c_5691 http://aims.fao.org/aos/agrovoc/c_27801 http://aims.fao.org/aos/agrovoc/c_928 http://aims.fao.org/aos/agrovoc/c_34335 http://aims.fao.org/aos/agrovoc/c_37958 http://aims.fao.org/aos/agrovoc/c_3041 http://aims.fao.org/aos/agrovoc/c_3def4163 http://aims.fao.org/aos/agrovoc/c_1335513885866 F60 - Physiologie et biochimie végétale C30 - Documentation et information peptide synthetase peptide polypeptide biosynthèse métabolite secondaire bioinformatique technique de prévision synthèse bibliographie http://aims.fao.org/aos/agrovoc/c_13231 http://aims.fao.org/aos/agrovoc/c_5691 http://aims.fao.org/aos/agrovoc/c_27801 http://aims.fao.org/aos/agrovoc/c_928 http://aims.fao.org/aos/agrovoc/c_34335 http://aims.fao.org/aos/agrovoc/c_37958 http://aims.fao.org/aos/agrovoc/c_3041 http://aims.fao.org/aos/agrovoc/c_3def4163 http://aims.fao.org/aos/agrovoc/c_1335513885866 |
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F60 - Physiologie et biochimie végétale C30 - Documentation et information peptide synthetase peptide polypeptide biosynthèse métabolite secondaire bioinformatique technique de prévision synthèse bibliographie http://aims.fao.org/aos/agrovoc/c_13231 http://aims.fao.org/aos/agrovoc/c_5691 http://aims.fao.org/aos/agrovoc/c_27801 http://aims.fao.org/aos/agrovoc/c_928 http://aims.fao.org/aos/agrovoc/c_34335 http://aims.fao.org/aos/agrovoc/c_37958 http://aims.fao.org/aos/agrovoc/c_3041 http://aims.fao.org/aos/agrovoc/c_3def4163 http://aims.fao.org/aos/agrovoc/c_1335513885866 F60 - Physiologie et biochimie végétale C30 - Documentation et information peptide synthetase peptide polypeptide biosynthèse métabolite secondaire bioinformatique technique de prévision synthèse bibliographie http://aims.fao.org/aos/agrovoc/c_13231 http://aims.fao.org/aos/agrovoc/c_5691 http://aims.fao.org/aos/agrovoc/c_27801 http://aims.fao.org/aos/agrovoc/c_928 http://aims.fao.org/aos/agrovoc/c_34335 http://aims.fao.org/aos/agrovoc/c_37958 http://aims.fao.org/aos/agrovoc/c_3041 http://aims.fao.org/aos/agrovoc/c_3def4163 http://aims.fao.org/aos/agrovoc/c_1335513885866 Duban, Matthieu Cociancich, Stéphane Leclère, Valérie Nonribosomal peptide synthesis definitely working out of the rules |
description |
Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields. They are built up by huge multimodular enzymes called nonribosomal peptide synthetases. These synthetases are organized in modules constituted of adenylation, thiolation, and condensation core domains. As such, each module governs, according to the collinearity rule, the incorporation of a monomer within the growing peptide. The release of the peptide from the assembly chain is finally performed by a terminal core thioesterase domain. Secondary domains with modifying catalytic activities such as epimerization or methylation are sometimes included in the assembly lines as supplementary domains. This assembly line structure is analyzed by bioinformatics tools to predict the sequence and structure of the final peptides according to the sequence of the corresponding synthetases. However, a constantly expanding literature unravels new examples of nonribosomal synthetases exhibiting very rare domains and noncanonical organizations of domains and modules, leading to several amazing strategies developed by microorganisms to synthesize nonribosomal peptides. In this review, through several examples, we aim at highlighting these noncanonical pathways in order for the readers to perceive their complexity. |
format |
article |
topic_facet |
F60 - Physiologie et biochimie végétale C30 - Documentation et information peptide synthetase peptide polypeptide biosynthèse métabolite secondaire bioinformatique technique de prévision synthèse bibliographie http://aims.fao.org/aos/agrovoc/c_13231 http://aims.fao.org/aos/agrovoc/c_5691 http://aims.fao.org/aos/agrovoc/c_27801 http://aims.fao.org/aos/agrovoc/c_928 http://aims.fao.org/aos/agrovoc/c_34335 http://aims.fao.org/aos/agrovoc/c_37958 http://aims.fao.org/aos/agrovoc/c_3041 http://aims.fao.org/aos/agrovoc/c_3def4163 http://aims.fao.org/aos/agrovoc/c_1335513885866 |
author |
Duban, Matthieu Cociancich, Stéphane Leclère, Valérie |
author_facet |
Duban, Matthieu Cociancich, Stéphane Leclère, Valérie |
author_sort |
Duban, Matthieu |
title |
Nonribosomal peptide synthesis definitely working out of the rules |
title_short |
Nonribosomal peptide synthesis definitely working out of the rules |
title_full |
Nonribosomal peptide synthesis definitely working out of the rules |
title_fullStr |
Nonribosomal peptide synthesis definitely working out of the rules |
title_full_unstemmed |
Nonribosomal peptide synthesis definitely working out of the rules |
title_sort |
nonribosomal peptide synthesis definitely working out of the rules |
url |
http://agritrop.cirad.fr/600447/ http://agritrop.cirad.fr/600447/1/microorganisms-10-00577.pdf |
work_keys_str_mv |
AT dubanmatthieu nonribosomalpeptidesynthesisdefinitelyworkingoutoftherules AT cociancichstephane nonribosomalpeptidesynthesisdefinitelyworkingoutoftherules AT leclerevalerie nonribosomalpeptidesynthesisdefinitelyworkingoutoftherules |
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1792500316900425728 |