Search for selection signatures related to trypanosomosis tolerance in African goats
Livestock is heavily affected by trypanosomosis in Africa. Through strong selective pressure, several African indigenous breeds of cattle and small ruminants have acquired varying degrees of tolerance against this disease. In this study, we combined LFMM and PCAdapt for analyzing two datasets of goats from West-Central Africa and East Africa, respectively, both comprising breeds with different assumed levels of trypanotolerance. The objectives were (i) to identify molecular signatures of selection related to trypanotolerance; and (ii) to guide an optimal sampling for subsequent studies. From 33 identified signatures, 18 had been detected previously in the literature as being mainly associated with climatic adaptations. The most plausible signatures of trypanotolerance indicate the genes DIS3L2, COPS7B, PD5A, UBE2K, and UBR1. The last gene is of particular interest since previous literature has already identified E3-ubiquitin ligases as playing a decisive role in the immune response. For following-up on these findings, the West-Central African area appears particularly relevant because of (i) a clear parasitic load gradient related to a humidity gradient, and (ii) still restricted admixture levels between goat breeds. This study illustrates the importance of protecting local breeds, which have retained unique allelic combinations conferring their remarkable adaptations.
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Format: | article biblioteca |
Language: | eng |
Subjects: | L73 - Maladies des animaux, trypanosomose, tolérance, caprin, résistance aux maladies, maladie des animaux, http://aims.fao.org/aos/agrovoc/c_7988, http://aims.fao.org/aos/agrovoc/c_37740, http://aims.fao.org/aos/agrovoc/c_3324, http://aims.fao.org/aos/agrovoc/c_2328, http://aims.fao.org/aos/agrovoc/c_426, http://aims.fao.org/aos/agrovoc/c_8081, http://aims.fao.org/aos/agrovoc/c_1229, http://aims.fao.org/aos/agrovoc/c_4540, http://aims.fao.org/aos/agrovoc/c_5182, http://aims.fao.org/aos/agrovoc/c_1159, http://aims.fao.org/aos/agrovoc/c_4086, http://aims.fao.org/aos/agrovoc/c_7608, http://aims.fao.org/aos/agrovoc/c_8038, |
Online Access: | http://agritrop.cirad.fr/599022/ http://agritrop.cirad.fr/599022/1/Serranito%20et%20al%202021.pdf |
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dig-cirad-fr-5990222024-01-29T03:43:15Z http://agritrop.cirad.fr/599022/ http://agritrop.cirad.fr/599022/ Search for selection signatures related to trypanosomosis tolerance in African goats. Serranito Bruno, Taurisson-Mouret Dominique, Harkat Sahraoui, Laoun Abbas, Ouchene-Khelifi Nadjet-Amina, Pompanon François, Benjelloun Badr, Cecchi Giuliano, Thevenon Sophie, Lenstra Johannes A., Da Silva Anne. 2021. Frontiers in Genetics, 12:715732, 15 p.https://doi.org/10.3389/fgene.2021.715732 <https://doi.org/10.3389/fgene.2021.715732> Search for selection signatures related to trypanosomosis tolerance in African goats Serranito, Bruno Taurisson-Mouret, Dominique Harkat, Sahraoui Laoun, Abbas Ouchene-Khelifi, Nadjet-Amina Pompanon, François Benjelloun, Badr Cecchi, Giuliano Thevenon, Sophie Lenstra, Johannes A. Da Silva, Anne eng 2021 Frontiers in Genetics L73 - Maladies des animaux trypanosomose tolérance caprin résistance aux maladies maladie des animaux http://aims.fao.org/aos/agrovoc/c_7988 http://aims.fao.org/aos/agrovoc/c_37740 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_2328 http://aims.fao.org/aos/agrovoc/c_426 Burkina Faso Cameroun Mali Nigéria Burundi Kenya République-Unie de Tanzanie Ouganda http://aims.fao.org/aos/agrovoc/c_8081 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4540 http://aims.fao.org/aos/agrovoc/c_5182 http://aims.fao.org/aos/agrovoc/c_1159 http://aims.fao.org/aos/agrovoc/c_4086 http://aims.fao.org/aos/agrovoc/c_7608 http://aims.fao.org/aos/agrovoc/c_8038 Livestock is heavily affected by trypanosomosis in Africa. Through strong selective pressure, several African indigenous breeds of cattle and small ruminants have acquired varying degrees of tolerance against this disease. In this study, we combined LFMM and PCAdapt for analyzing two datasets of goats from West-Central Africa and East Africa, respectively, both comprising breeds with different assumed levels of trypanotolerance. The objectives were (i) to identify molecular signatures of selection related to trypanotolerance; and (ii) to guide an optimal sampling for subsequent studies. From 33 identified signatures, 18 had been detected previously in the literature as being mainly associated with climatic adaptations. The most plausible signatures of trypanotolerance indicate the genes DIS3L2, COPS7B, PD5A, UBE2K, and UBR1. The last gene is of particular interest since previous literature has already identified E3-ubiquitin ligases as playing a decisive role in the immune response. For following-up on these findings, the West-Central African area appears particularly relevant because of (i) a clear parasitic load gradient related to a humidity gradient, and (ii) still restricted admixture levels between goat breeds. This study illustrates the importance of protecting local breeds, which have retained unique allelic combinations conferring their remarkable adaptations. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/599022/1/Serranito%20et%20al%202021.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.3389/fgene.2021.715732 10.3389/fgene.2021.715732 info:eu-repo/semantics/altIdentifier/doi/10.3389/fgene.2021.715732 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.3389/fgene.2021.715732 |
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L73 - Maladies des animaux trypanosomose tolérance caprin résistance aux maladies maladie des animaux http://aims.fao.org/aos/agrovoc/c_7988 http://aims.fao.org/aos/agrovoc/c_37740 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_2328 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_8081 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4540 http://aims.fao.org/aos/agrovoc/c_5182 http://aims.fao.org/aos/agrovoc/c_1159 http://aims.fao.org/aos/agrovoc/c_4086 http://aims.fao.org/aos/agrovoc/c_7608 http://aims.fao.org/aos/agrovoc/c_8038 L73 - Maladies des animaux trypanosomose tolérance caprin résistance aux maladies maladie des animaux http://aims.fao.org/aos/agrovoc/c_7988 http://aims.fao.org/aos/agrovoc/c_37740 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_2328 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_8081 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4540 http://aims.fao.org/aos/agrovoc/c_5182 http://aims.fao.org/aos/agrovoc/c_1159 http://aims.fao.org/aos/agrovoc/c_4086 http://aims.fao.org/aos/agrovoc/c_7608 http://aims.fao.org/aos/agrovoc/c_8038 |
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L73 - Maladies des animaux trypanosomose tolérance caprin résistance aux maladies maladie des animaux http://aims.fao.org/aos/agrovoc/c_7988 http://aims.fao.org/aos/agrovoc/c_37740 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_2328 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_8081 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4540 http://aims.fao.org/aos/agrovoc/c_5182 http://aims.fao.org/aos/agrovoc/c_1159 http://aims.fao.org/aos/agrovoc/c_4086 http://aims.fao.org/aos/agrovoc/c_7608 http://aims.fao.org/aos/agrovoc/c_8038 L73 - Maladies des animaux trypanosomose tolérance caprin résistance aux maladies maladie des animaux http://aims.fao.org/aos/agrovoc/c_7988 http://aims.fao.org/aos/agrovoc/c_37740 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_2328 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_8081 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4540 http://aims.fao.org/aos/agrovoc/c_5182 http://aims.fao.org/aos/agrovoc/c_1159 http://aims.fao.org/aos/agrovoc/c_4086 http://aims.fao.org/aos/agrovoc/c_7608 http://aims.fao.org/aos/agrovoc/c_8038 Serranito, Bruno Taurisson-Mouret, Dominique Harkat, Sahraoui Laoun, Abbas Ouchene-Khelifi, Nadjet-Amina Pompanon, François Benjelloun, Badr Cecchi, Giuliano Thevenon, Sophie Lenstra, Johannes A. Da Silva, Anne Search for selection signatures related to trypanosomosis tolerance in African goats |
description |
Livestock is heavily affected by trypanosomosis in Africa. Through strong selective pressure, several African indigenous breeds of cattle and small ruminants have acquired varying degrees of tolerance against this disease. In this study, we combined LFMM and PCAdapt for analyzing two datasets of goats from West-Central Africa and East Africa, respectively, both comprising breeds with different assumed levels of trypanotolerance. The objectives were (i) to identify molecular signatures of selection related to trypanotolerance; and (ii) to guide an optimal sampling for subsequent studies. From 33 identified signatures, 18 had been detected previously in the literature as being mainly associated with climatic adaptations. The most plausible signatures of trypanotolerance indicate the genes DIS3L2, COPS7B, PD5A, UBE2K, and UBR1. The last gene is of particular interest since previous literature has already identified E3-ubiquitin ligases as playing a decisive role in the immune response. For following-up on these findings, the West-Central African area appears particularly relevant because of (i) a clear parasitic load gradient related to a humidity gradient, and (ii) still restricted admixture levels between goat breeds. This study illustrates the importance of protecting local breeds, which have retained unique allelic combinations conferring their remarkable adaptations. |
format |
article |
topic_facet |
L73 - Maladies des animaux trypanosomose tolérance caprin résistance aux maladies maladie des animaux http://aims.fao.org/aos/agrovoc/c_7988 http://aims.fao.org/aos/agrovoc/c_37740 http://aims.fao.org/aos/agrovoc/c_3324 http://aims.fao.org/aos/agrovoc/c_2328 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_8081 http://aims.fao.org/aos/agrovoc/c_1229 http://aims.fao.org/aos/agrovoc/c_4540 http://aims.fao.org/aos/agrovoc/c_5182 http://aims.fao.org/aos/agrovoc/c_1159 http://aims.fao.org/aos/agrovoc/c_4086 http://aims.fao.org/aos/agrovoc/c_7608 http://aims.fao.org/aos/agrovoc/c_8038 |
author |
Serranito, Bruno Taurisson-Mouret, Dominique Harkat, Sahraoui Laoun, Abbas Ouchene-Khelifi, Nadjet-Amina Pompanon, François Benjelloun, Badr Cecchi, Giuliano Thevenon, Sophie Lenstra, Johannes A. Da Silva, Anne |
author_facet |
Serranito, Bruno Taurisson-Mouret, Dominique Harkat, Sahraoui Laoun, Abbas Ouchene-Khelifi, Nadjet-Amina Pompanon, François Benjelloun, Badr Cecchi, Giuliano Thevenon, Sophie Lenstra, Johannes A. Da Silva, Anne |
author_sort |
Serranito, Bruno |
title |
Search for selection signatures related to trypanosomosis tolerance in African goats |
title_short |
Search for selection signatures related to trypanosomosis tolerance in African goats |
title_full |
Search for selection signatures related to trypanosomosis tolerance in African goats |
title_fullStr |
Search for selection signatures related to trypanosomosis tolerance in African goats |
title_full_unstemmed |
Search for selection signatures related to trypanosomosis tolerance in African goats |
title_sort |
search for selection signatures related to trypanosomosis tolerance in african goats |
url |
http://agritrop.cirad.fr/599022/ http://agritrop.cirad.fr/599022/1/Serranito%20et%20al%202021.pdf |
work_keys_str_mv |
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