Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study
Bats are natural reservoirs of the largest proportion of viral zoonoses among mammals, thus understanding the conditions for pathogen persistence in bats is essential to reduce human risk. Focusing on the European Bat Lyssavirus subtype 1 (EBLV-1), causing rabies disease, we develop a data-driven spatially explicit metapopulation model to investigate EBLV-1 persistence in Myotis myotis and Miniopterus schreibersii bat species in Catalonia. We find that persistence relies on host spatial structure through the migratory nature of M. schreibersii, on cross-species mixing with M. myotis, and on survival of infected animals followed by temporary immunity. The virus would not persist in the single colony of M. myotis. Our study provides for the first time epidemiological estimates for EBLV-1 progression in M. schreibersii. Our approach can be readily adapted to other zoonoses of public health concern where long-range migration and habitat sharing may play an important role.
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Subjects: | L73 - Maladies des animaux, Chiroptera, http://aims.fao.org/aos/agrovoc/c_1560, http://aims.fao.org/aos/agrovoc/c_2724, |
Online Access: | http://agritrop.cirad.fr/591721/ http://agritrop.cirad.fr/591721/1/s41598-018-36485-y.pdf |
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dig-cirad-fr-5917212023-12-01T17:01:21Z http://agritrop.cirad.fr/591721/ http://agritrop.cirad.fr/591721/ Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study. Colombi Davide, Serra-Cobo Jordi, Metras Raphaëlle, Apolloni Andrea, Poletto Chiara, López-Roig Marc, Bourhy Hervé, Colizza Vittoria. 2019. Scientific Reports, 9:537https://doi.org/10.1038/s41598-018-36485-y <https://doi.org/10.1038/s41598-018-36485-y> Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study Colombi, Davide Serra-Cobo, Jordi Metras, Raphaëlle Apolloni, Andrea Poletto, Chiara López-Roig, Marc Bourhy, Hervé Colizza, Vittoria eng 2019 Scientific Reports L73 - Maladies des animaux Chiroptera http://aims.fao.org/aos/agrovoc/c_1560 Europe http://aims.fao.org/aos/agrovoc/c_2724 Bats are natural reservoirs of the largest proportion of viral zoonoses among mammals, thus understanding the conditions for pathogen persistence in bats is essential to reduce human risk. Focusing on the European Bat Lyssavirus subtype 1 (EBLV-1), causing rabies disease, we develop a data-driven spatially explicit metapopulation model to investigate EBLV-1 persistence in Myotis myotis and Miniopterus schreibersii bat species in Catalonia. We find that persistence relies on host spatial structure through the migratory nature of M. schreibersii, on cross-species mixing with M. myotis, and on survival of infected animals followed by temporary immunity. The virus would not persist in the single colony of M. myotis. Our study provides for the first time epidemiological estimates for EBLV-1 progression in M. schreibersii. Our approach can be readily adapted to other zoonoses of public health concern where long-range migration and habitat sharing may play an important role. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/591721/1/s41598-018-36485-y.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.1038/s41598-018-36485-y 10.1038/s41598-018-36485-y info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-36485-y info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1038/s41598-018-36485-y |
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L73 - Maladies des animaux Chiroptera http://aims.fao.org/aos/agrovoc/c_1560 http://aims.fao.org/aos/agrovoc/c_2724 L73 - Maladies des animaux Chiroptera http://aims.fao.org/aos/agrovoc/c_1560 http://aims.fao.org/aos/agrovoc/c_2724 |
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L73 - Maladies des animaux Chiroptera http://aims.fao.org/aos/agrovoc/c_1560 http://aims.fao.org/aos/agrovoc/c_2724 L73 - Maladies des animaux Chiroptera http://aims.fao.org/aos/agrovoc/c_1560 http://aims.fao.org/aos/agrovoc/c_2724 Colombi, Davide Serra-Cobo, Jordi Metras, Raphaëlle Apolloni, Andrea Poletto, Chiara López-Roig, Marc Bourhy, Hervé Colizza, Vittoria Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study |
description |
Bats are natural reservoirs of the largest proportion of viral zoonoses among mammals, thus understanding the conditions for pathogen persistence in bats is essential to reduce human risk. Focusing on the European Bat Lyssavirus subtype 1 (EBLV-1), causing rabies disease, we develop a data-driven spatially explicit metapopulation model to investigate EBLV-1 persistence in Myotis myotis and Miniopterus schreibersii bat species in Catalonia. We find that persistence relies on host spatial structure through the migratory nature of M. schreibersii, on cross-species mixing with M. myotis, and on survival of infected animals followed by temporary immunity. The virus would not persist in the single colony of M. myotis. Our study provides for the first time epidemiological estimates for EBLV-1 progression in M. schreibersii. Our approach can be readily adapted to other zoonoses of public health concern where long-range migration and habitat sharing may play an important role. |
format |
article |
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L73 - Maladies des animaux Chiroptera http://aims.fao.org/aos/agrovoc/c_1560 http://aims.fao.org/aos/agrovoc/c_2724 |
author |
Colombi, Davide Serra-Cobo, Jordi Metras, Raphaëlle Apolloni, Andrea Poletto, Chiara López-Roig, Marc Bourhy, Hervé Colizza, Vittoria |
author_facet |
Colombi, Davide Serra-Cobo, Jordi Metras, Raphaëlle Apolloni, Andrea Poletto, Chiara López-Roig, Marc Bourhy, Hervé Colizza, Vittoria |
author_sort |
Colombi, Davide |
title |
Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study |
title_short |
Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study |
title_full |
Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study |
title_fullStr |
Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study |
title_full_unstemmed |
Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: Insights from a modeling study |
title_sort |
mechanisms for lyssavirus persistence in non-synanthropic bats in europe: insights from a modeling study |
url |
http://agritrop.cirad.fr/591721/ http://agritrop.cirad.fr/591721/1/s41598-018-36485-y.pdf |
work_keys_str_mv |
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