Frequency of bacteriuria in dogs with chronic kidney disease: A retrospective study of 201 cases

Background: Studies have shown an increased prevalence of positive urine culture (PUC) in cats with chronic kidney disease (CKD); no information is available in dogs. Objectives: To document the PUC frequency in a cohort of dogs with CKD, determine risk factors for PUC, and identify associations between clinicopathologic data and PUC. Animals: Two hundred one client‐owned dogs with CKD. Methods: Retrospective, observational study. Dogs recruited from 2 veterinary teaching hospitals were included if they were diagnosed with CKD and had a culture performed on urine collected by cystocentesis. The PUC frequency was calculated, multivariate analysis was performed to identify risk factors, and associations with clinicopathologic data were investigated. Results: Sixty‐five dogs (32%) with CKD had PUC, including 8 (28%) in International Renal Interest Society (IRIS) stage 1; only 8% showed signs of a urinary tract infection. Escherichia coli was the most common isolate (67%). A PUC was more likely in females (odds ratio [OR], 3.22; 95% confidence interval [CI], 1.67‐6.37; P < .001) than males and in dogs with isosthenuria (OR, 2.48; 95% CI, 1.24‐5.03; P = .01) than in dogs with urine‐specific gravity 1.013‐1.024. A positive leukocyte esterase test and microorganisms found by urine sediment analysis were significantly associated with PUC (both P < .001). Conclusions and Clinical Importance: Dogs with CKD, even IRIS stage 1, have a high frequency of PUC and most cases are asymptomatic. A urine culture could be considered in the routine evaluation of dogs with CKD, but the clinical relevance of a PUC remains unknown and needs further evaluation.

Bibliographic Details

Main Authors:	Lamoureux, Anaïs, Da Riz, Fiona, Cappelle, Julien, Boulouis, Henri-Jean, Benchekroun, Ghita, Cadoré, Jean-Luc, Krafft, Emilie, Maurey, Christelle
Format:	article biblioteca
Language:	eng
Subjects:	L73 - Maladies des animaux, L74 - Troubles divers des animaux, santé animale, chien, néphropathie, urine, trouble urinaire, http://aims.fao.org/aos/agrovoc/c_431, http://aims.fao.org/aos/agrovoc/c_2352, http://aims.fao.org/aos/agrovoc/c_11973, http://aims.fao.org/aos/agrovoc/c_8103, http://aims.fao.org/aos/agrovoc/c_8102,
Online Access:	http://agritrop.cirad.fr/591286/ http://agritrop.cirad.fr/591286/7/Lamoureux_et_al-2019-Journal_of_Veterinary_Internal_Medicine.pdf
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