Escaping deleterious immune response in their hosts: Lessons from trypanosomatids
The Trypanosomatidae family includes the genera Trypanosoma and Leishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector. Trypanosoma brucei gambiense, Trypanosoma cruzi, and Leishmania spp. are important human pathogens causing human African trypanosomiasis (HAT or sleeping sickness), Chagas' disease, and various clinical forms of Leishmaniasis, respectively. They are transmitted to humans by tsetse flies, triatomine bugs, or sandflies, and affect millions of people worldwide. In humans, extracellular African trypanosomes (T. brucei) evade the hosts' immune defenses, allowing their transmission to the next host, via the tsetse vector. By contrast, T. cruzi and Leishmania sp. have developed a complex intracellular lifestyle, also preventing several mechanisms to circumvent the host's immune response. This review seeks to set out the immune evasion strategies developed by the different trypanosomatids resulting from parasite–host interactions and will focus on: clinical and epidemiological importance of diseases; life cycles: parasites–hosts–vectors; innate immunity: key steps for trypanosomatids in invading hosts; deregulation of antigen-presenting cells; disruption of efficient specific immunity; and the immune responses used for parasite proliferation.
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dig-cirad-fr-5806442024-01-28T23:31:17Z http://agritrop.cirad.fr/580644/ http://agritrop.cirad.fr/580644/ Escaping deleterious immune response in their hosts: Lessons from trypanosomatids. Geiger Anne, Bossard Géraldine, Sereno Denis, Pissarra Joana, Lemesre Jean-Loup, Vincendeau Philippe, Holzmuller Philippe. 2016. Frontiers in Immunology, 7:212, 21 p.https://doi.org/10.3389/fimmu.2016.00212 <https://doi.org/10.3389/fimmu.2016.00212> Escaping deleterious immune response in their hosts: Lessons from trypanosomatids Geiger, Anne Bossard, Géraldine Sereno, Denis Pissarra, Joana Lemesre, Jean-Loup Vincendeau, Philippe Holzmuller, Philippe eng 2016 Frontiers in Immunology L72 - Organismes nuisibles des animaux L73 - Maladies des animaux 000 - Autres thèmes Trypanosoma Leishmania Trypanosoma cruzi Trypanosoma brucei relation hôte parasite transmission des maladies interactions biologiques immunodépression hôte cycle de développement immunité réponse immunitaire famille (taxon) vecteur de maladie maladie de l'homme maladie des animaux immunologie parasitisme Insecta Vertebrata http://aims.fao.org/aos/agrovoc/c_7987 http://aims.fao.org/aos/agrovoc/c_24350 http://aims.fao.org/aos/agrovoc/c_27402 http://aims.fao.org/aos/agrovoc/c_27400 http://aims.fao.org/aos/agrovoc/c_11620 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_49896 http://aims.fao.org/aos/agrovoc/c_26861 http://aims.fao.org/aos/agrovoc/c_3673 http://aims.fao.org/aos/agrovoc/c_4317 http://aims.fao.org/aos/agrovoc/c_3802 http://aims.fao.org/aos/agrovoc/c_3799 http://aims.fao.org/aos/agrovoc/c_330937 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_3808 http://aims.fao.org/aos/agrovoc/c_5577 http://aims.fao.org/aos/agrovoc/c_3890 http://aims.fao.org/aos/agrovoc/c_331312 The Trypanosomatidae family includes the genera Trypanosoma and Leishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector. Trypanosoma brucei gambiense, Trypanosoma cruzi, and Leishmania spp. are important human pathogens causing human African trypanosomiasis (HAT or sleeping sickness), Chagas' disease, and various clinical forms of Leishmaniasis, respectively. They are transmitted to humans by tsetse flies, triatomine bugs, or sandflies, and affect millions of people worldwide. In humans, extracellular African trypanosomes (T. brucei) evade the hosts' immune defenses, allowing their transmission to the next host, via the tsetse vector. By contrast, T. cruzi and Leishmania sp. have developed a complex intracellular lifestyle, also preventing several mechanisms to circumvent the host's immune response. This review seeks to set out the immune evasion strategies developed by the different trypanosomatids resulting from parasite–host interactions and will focus on: clinical and epidemiological importance of diseases; life cycles: parasites–hosts–vectors; innate immunity: key steps for trypanosomatids in invading hosts; deregulation of antigen-presenting cells; disruption of efficient specific immunity; and the immune responses used for parasite proliferation. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/580644/1/fimmu-07-00212.pdf text Cirad license info:eu-repo/semantics/openAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.3389/fimmu.2016.00212 10.3389/fimmu.2016.00212 info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2016.00212 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.3389/fimmu.2016.00212 |
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L72 - Organismes nuisibles des animaux L73 - Maladies des animaux 000 - Autres thèmes Trypanosoma Leishmania Trypanosoma cruzi Trypanosoma brucei relation hôte parasite transmission des maladies interactions biologiques immunodépression hôte cycle de développement immunité réponse immunitaire famille (taxon) vecteur de maladie maladie de l'homme maladie des animaux immunologie parasitisme Insecta Vertebrata http://aims.fao.org/aos/agrovoc/c_7987 http://aims.fao.org/aos/agrovoc/c_24350 http://aims.fao.org/aos/agrovoc/c_27402 http://aims.fao.org/aos/agrovoc/c_27400 http://aims.fao.org/aos/agrovoc/c_11620 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_49896 http://aims.fao.org/aos/agrovoc/c_26861 http://aims.fao.org/aos/agrovoc/c_3673 http://aims.fao.org/aos/agrovoc/c_4317 http://aims.fao.org/aos/agrovoc/c_3802 http://aims.fao.org/aos/agrovoc/c_3799 http://aims.fao.org/aos/agrovoc/c_330937 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_3808 http://aims.fao.org/aos/agrovoc/c_5577 http://aims.fao.org/aos/agrovoc/c_3890 http://aims.fao.org/aos/agrovoc/c_331312 L72 - Organismes nuisibles des animaux L73 - Maladies des animaux 000 - Autres thèmes Trypanosoma Leishmania Trypanosoma cruzi Trypanosoma brucei relation hôte parasite transmission des maladies interactions biologiques immunodépression hôte cycle de développement immunité réponse immunitaire famille (taxon) vecteur de maladie maladie de l'homme maladie des animaux immunologie parasitisme Insecta Vertebrata http://aims.fao.org/aos/agrovoc/c_7987 http://aims.fao.org/aos/agrovoc/c_24350 http://aims.fao.org/aos/agrovoc/c_27402 http://aims.fao.org/aos/agrovoc/c_27400 http://aims.fao.org/aos/agrovoc/c_11620 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_49896 http://aims.fao.org/aos/agrovoc/c_26861 http://aims.fao.org/aos/agrovoc/c_3673 http://aims.fao.org/aos/agrovoc/c_4317 http://aims.fao.org/aos/agrovoc/c_3802 http://aims.fao.org/aos/agrovoc/c_3799 http://aims.fao.org/aos/agrovoc/c_330937 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_3808 http://aims.fao.org/aos/agrovoc/c_5577 http://aims.fao.org/aos/agrovoc/c_3890 http://aims.fao.org/aos/agrovoc/c_331312 |
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L72 - Organismes nuisibles des animaux L73 - Maladies des animaux 000 - Autres thèmes Trypanosoma Leishmania Trypanosoma cruzi Trypanosoma brucei relation hôte parasite transmission des maladies interactions biologiques immunodépression hôte cycle de développement immunité réponse immunitaire famille (taxon) vecteur de maladie maladie de l'homme maladie des animaux immunologie parasitisme Insecta Vertebrata http://aims.fao.org/aos/agrovoc/c_7987 http://aims.fao.org/aos/agrovoc/c_24350 http://aims.fao.org/aos/agrovoc/c_27402 http://aims.fao.org/aos/agrovoc/c_27400 http://aims.fao.org/aos/agrovoc/c_11620 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_49896 http://aims.fao.org/aos/agrovoc/c_26861 http://aims.fao.org/aos/agrovoc/c_3673 http://aims.fao.org/aos/agrovoc/c_4317 http://aims.fao.org/aos/agrovoc/c_3802 http://aims.fao.org/aos/agrovoc/c_3799 http://aims.fao.org/aos/agrovoc/c_330937 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_3808 http://aims.fao.org/aos/agrovoc/c_5577 http://aims.fao.org/aos/agrovoc/c_3890 http://aims.fao.org/aos/agrovoc/c_331312 L72 - Organismes nuisibles des animaux L73 - Maladies des animaux 000 - Autres thèmes Trypanosoma Leishmania Trypanosoma cruzi Trypanosoma brucei relation hôte parasite transmission des maladies interactions biologiques immunodépression hôte cycle de développement immunité réponse immunitaire famille (taxon) vecteur de maladie maladie de l'homme maladie des animaux immunologie parasitisme Insecta Vertebrata http://aims.fao.org/aos/agrovoc/c_7987 http://aims.fao.org/aos/agrovoc/c_24350 http://aims.fao.org/aos/agrovoc/c_27402 http://aims.fao.org/aos/agrovoc/c_27400 http://aims.fao.org/aos/agrovoc/c_11620 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_49896 http://aims.fao.org/aos/agrovoc/c_26861 http://aims.fao.org/aos/agrovoc/c_3673 http://aims.fao.org/aos/agrovoc/c_4317 http://aims.fao.org/aos/agrovoc/c_3802 http://aims.fao.org/aos/agrovoc/c_3799 http://aims.fao.org/aos/agrovoc/c_330937 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_3808 http://aims.fao.org/aos/agrovoc/c_5577 http://aims.fao.org/aos/agrovoc/c_3890 http://aims.fao.org/aos/agrovoc/c_331312 Geiger, Anne Bossard, Géraldine Sereno, Denis Pissarra, Joana Lemesre, Jean-Loup Vincendeau, Philippe Holzmuller, Philippe Escaping deleterious immune response in their hosts: Lessons from trypanosomatids |
description |
The Trypanosomatidae family includes the genera Trypanosoma and Leishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector. Trypanosoma brucei gambiense, Trypanosoma cruzi, and Leishmania spp. are important human pathogens causing human African trypanosomiasis (HAT or sleeping sickness), Chagas' disease, and various clinical forms of Leishmaniasis, respectively. They are transmitted to humans by tsetse flies, triatomine bugs, or sandflies, and affect millions of people worldwide. In humans, extracellular African trypanosomes (T. brucei) evade the hosts' immune defenses, allowing their transmission to the next host, via the tsetse vector. By contrast, T. cruzi and Leishmania sp. have developed a complex intracellular lifestyle, also preventing several mechanisms to circumvent the host's immune response. This review seeks to set out the immune evasion strategies developed by the different trypanosomatids resulting from parasite–host interactions and will focus on: clinical and epidemiological importance of diseases; life cycles: parasites–hosts–vectors; innate immunity: key steps for trypanosomatids in invading hosts; deregulation of antigen-presenting cells; disruption of efficient specific immunity; and the immune responses used for parasite proliferation. |
format |
article |
topic_facet |
L72 - Organismes nuisibles des animaux L73 - Maladies des animaux 000 - Autres thèmes Trypanosoma Leishmania Trypanosoma cruzi Trypanosoma brucei relation hôte parasite transmission des maladies interactions biologiques immunodépression hôte cycle de développement immunité réponse immunitaire famille (taxon) vecteur de maladie maladie de l'homme maladie des animaux immunologie parasitisme Insecta Vertebrata http://aims.fao.org/aos/agrovoc/c_7987 http://aims.fao.org/aos/agrovoc/c_24350 http://aims.fao.org/aos/agrovoc/c_27402 http://aims.fao.org/aos/agrovoc/c_27400 http://aims.fao.org/aos/agrovoc/c_11620 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_49896 http://aims.fao.org/aos/agrovoc/c_26861 http://aims.fao.org/aos/agrovoc/c_3673 http://aims.fao.org/aos/agrovoc/c_4317 http://aims.fao.org/aos/agrovoc/c_3802 http://aims.fao.org/aos/agrovoc/c_3799 http://aims.fao.org/aos/agrovoc/c_330937 http://aims.fao.org/aos/agrovoc/c_8164 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_426 http://aims.fao.org/aos/agrovoc/c_3808 http://aims.fao.org/aos/agrovoc/c_5577 http://aims.fao.org/aos/agrovoc/c_3890 http://aims.fao.org/aos/agrovoc/c_331312 |
author |
Geiger, Anne Bossard, Géraldine Sereno, Denis Pissarra, Joana Lemesre, Jean-Loup Vincendeau, Philippe Holzmuller, Philippe |
author_facet |
Geiger, Anne Bossard, Géraldine Sereno, Denis Pissarra, Joana Lemesre, Jean-Loup Vincendeau, Philippe Holzmuller, Philippe |
author_sort |
Geiger, Anne |
title |
Escaping deleterious immune response in their hosts: Lessons from trypanosomatids |
title_short |
Escaping deleterious immune response in their hosts: Lessons from trypanosomatids |
title_full |
Escaping deleterious immune response in their hosts: Lessons from trypanosomatids |
title_fullStr |
Escaping deleterious immune response in their hosts: Lessons from trypanosomatids |
title_full_unstemmed |
Escaping deleterious immune response in their hosts: Lessons from trypanosomatids |
title_sort |
escaping deleterious immune response in their hosts: lessons from trypanosomatids |
url |
http://agritrop.cirad.fr/580644/ http://agritrop.cirad.fr/580644/1/fimmu-07-00212.pdf |
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