Trypanosome-induced Interferon-γ production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections

Control of human African trypanosomiasis (HAT) is highly dependent on the ability to detect and treat infected individuals. However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels in blood. They are long-term potential reservoirs and thus a threat for control strategies. Cytokine responses in whole blood stimulation assays were quantified in individuals with contrasting HAT status. Trypanosome-induced IFN-γ production was only observed in “trypanotolerant” subjects suspected of harboring latent infections. This result contributes new insights into the immune responses associated with infection control and opens novel diagnosis perspectives regarding HAT elimination.

Bibliographic Details

Main Authors:	Ilboudo, Hamidou, Jamonneau, Vincent, Koffi, Mathurin, Kaboré, Jacques, Amoussa, Roukiyath, Holzmuller, Philippe, Garcia, André, Bucheton, Bruno, Courtin, David
Format:	article biblioteca
Language:	eng
Subjects:	L73 - Maladies des animaux, 000 - Autres thèmes, L72 - Organismes nuisibles des animaux, Trypanosoma brucei, maladie de l'homme, tolérance, cytokine, immunologie, contrôle de maladies, sang, diagnostic, interféron, réponse immunitaire, http://aims.fao.org/aos/agrovoc/c_27400, http://aims.fao.org/aos/agrovoc/c_29198, http://aims.fao.org/aos/agrovoc/c_37740, http://aims.fao.org/aos/agrovoc/c_35078, http://aims.fao.org/aos/agrovoc/c_3808, http://aims.fao.org/aos/agrovoc/c_2327, http://aims.fao.org/aos/agrovoc/c_959, http://aims.fao.org/aos/agrovoc/c_2238, http://aims.fao.org/aos/agrovoc/c_3914, http://aims.fao.org/aos/agrovoc/c_3799, http://aims.fao.org/aos/agrovoc/c_4027,
Online Access:	http://agritrop.cirad.fr/580617/ http://agritrop.cirad.fr/580617/1/1-s2.0-S1286457916000484-main.pdf
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