First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS
The applicability of a multi-step generic procedure to systematically develop sample preparation methods for the detection, characterization, and quantification of inorganic engineered nanoparticles (ENPs) in a complex matrix was successfully demonstrated. The research focused on the optimization of the sample preparation, aiming to achieve a complete separation of ENPs from a complex matrix without altering the ENP size distribution and with minimal loss of ENPs. The separated ENPs were detected and further characterized in terms of particle size distribution and quantified in terms of elemental mass content by asymmetric flow-field flow fractionation coupled to a multi-angle light scattering detector and an inductively coupled plasma mass spectrometer. Following the proposed generic procedure SiO2-ENPs were separated from a tomato soup. Two potential sample preparation methods were tested these being acid digestion and colloidal extraction. With the developed method a complete SiO2-ENPs and matrix separation with a Si mass recovery >90% was achieved by acid digestion. The alteration of the particle size distribution was minimized by particle stabilization. The generic procedure which also provides quality criteria for method development is urgently needed for standardized and systematic development of procedures for separation of ENPs from a complex matrix. The chosen analytical technique was shown to be suitable for detecting SiO2-ENPs in a complex food matrix like tomato soup and may therefore be extended to monitor the existence of ENPs during production and safety control of foodstuffs, food labelling, and compliance with legislative limits.
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Language: | eng |
Subjects: | U30 - Méthodes de recherche, 000 - Autres thèmes, technique analytique, propriété physicochimique, législation alimentaire, nanoparticules, http://aims.fao.org/aos/agrovoc/c_1513, http://aims.fao.org/aos/agrovoc/c_1521, http://aims.fao.org/aos/agrovoc/c_28695, http://aims.fao.org/aos/agrovoc/c_93f051ee, |
Online Access: | http://agritrop.cirad.fr/578434/ http://agritrop.cirad.fr/578434/1/Wagner%20et%20al%20JAAS%202015.pdf |
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dig-cirad-fr-5784342024-01-29T05:33:34Z http://agritrop.cirad.fr/578434/ http://agritrop.cirad.fr/578434/ First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS. Wagner Stephan, Legros Samuel, Loeschner Katrin, Liu Junfeng, Navratilova Jana, Grombe Ringo, Linsinger T.P.J., Larsen Erik H., Von der Kammer Frank, Hofmann Thilo. 2015. Journal of Analytical Atomic Spectrometry, 30 (6) : 1286-1296.https://doi.org/10.1039/c4ja00471j <https://doi.org/10.1039/c4ja00471j> First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS Wagner, Stephan Legros, Samuel Loeschner, Katrin Liu, Junfeng Navratilova, Jana Grombe, Ringo Linsinger, T.P.J. Larsen, Erik H. Von der Kammer, Frank Hofmann, Thilo eng 2015 Journal of Analytical Atomic Spectrometry U30 - Méthodes de recherche 000 - Autres thèmes technique analytique propriété physicochimique législation alimentaire nanoparticules http://aims.fao.org/aos/agrovoc/c_1513 http://aims.fao.org/aos/agrovoc/c_1521 http://aims.fao.org/aos/agrovoc/c_28695 http://aims.fao.org/aos/agrovoc/c_93f051ee The applicability of a multi-step generic procedure to systematically develop sample preparation methods for the detection, characterization, and quantification of inorganic engineered nanoparticles (ENPs) in a complex matrix was successfully demonstrated. The research focused on the optimization of the sample preparation, aiming to achieve a complete separation of ENPs from a complex matrix without altering the ENP size distribution and with minimal loss of ENPs. The separated ENPs were detected and further characterized in terms of particle size distribution and quantified in terms of elemental mass content by asymmetric flow-field flow fractionation coupled to a multi-angle light scattering detector and an inductively coupled plasma mass spectrometer. Following the proposed generic procedure SiO2-ENPs were separated from a tomato soup. Two potential sample preparation methods were tested these being acid digestion and colloidal extraction. With the developed method a complete SiO2-ENPs and matrix separation with a Si mass recovery >90% was achieved by acid digestion. The alteration of the particle size distribution was minimized by particle stabilization. The generic procedure which also provides quality criteria for method development is urgently needed for standardized and systematic development of procedures for separation of ENPs from a complex matrix. The chosen analytical technique was shown to be suitable for detecting SiO2-ENPs in a complex food matrix like tomato soup and may therefore be extended to monitor the existence of ENPs during production and safety control of foodstuffs, food labelling, and compliance with legislative limits. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/578434/1/Wagner%20et%20al%20JAAS%202015.pdf text Cirad license info:eu-repo/semantics/openAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1039/c4ja00471j 10.1039/c4ja00471j info:eu-repo/semantics/altIdentifier/doi/10.1039/c4ja00471j info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1039/c4ja00471j |
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U30 - Méthodes de recherche 000 - Autres thèmes technique analytique propriété physicochimique législation alimentaire nanoparticules http://aims.fao.org/aos/agrovoc/c_1513 http://aims.fao.org/aos/agrovoc/c_1521 http://aims.fao.org/aos/agrovoc/c_28695 http://aims.fao.org/aos/agrovoc/c_93f051ee U30 - Méthodes de recherche 000 - Autres thèmes technique analytique propriété physicochimique législation alimentaire nanoparticules http://aims.fao.org/aos/agrovoc/c_1513 http://aims.fao.org/aos/agrovoc/c_1521 http://aims.fao.org/aos/agrovoc/c_28695 http://aims.fao.org/aos/agrovoc/c_93f051ee |
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U30 - Méthodes de recherche 000 - Autres thèmes technique analytique propriété physicochimique législation alimentaire nanoparticules http://aims.fao.org/aos/agrovoc/c_1513 http://aims.fao.org/aos/agrovoc/c_1521 http://aims.fao.org/aos/agrovoc/c_28695 http://aims.fao.org/aos/agrovoc/c_93f051ee U30 - Méthodes de recherche 000 - Autres thèmes technique analytique propriété physicochimique législation alimentaire nanoparticules http://aims.fao.org/aos/agrovoc/c_1513 http://aims.fao.org/aos/agrovoc/c_1521 http://aims.fao.org/aos/agrovoc/c_28695 http://aims.fao.org/aos/agrovoc/c_93f051ee Wagner, Stephan Legros, Samuel Loeschner, Katrin Liu, Junfeng Navratilova, Jana Grombe, Ringo Linsinger, T.P.J. Larsen, Erik H. Von der Kammer, Frank Hofmann, Thilo First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS |
description |
The applicability of a multi-step generic procedure to systematically develop sample preparation methods for the detection, characterization, and quantification of inorganic engineered nanoparticles (ENPs) in a complex matrix was successfully demonstrated. The research focused on the optimization of the sample preparation, aiming to achieve a complete separation of ENPs from a complex matrix without altering the ENP size distribution and with minimal loss of ENPs. The separated ENPs were detected and further characterized in terms of particle size distribution and quantified in terms of elemental mass content by asymmetric flow-field flow fractionation coupled to a multi-angle light scattering detector and an inductively coupled plasma mass spectrometer. Following the proposed generic procedure SiO2-ENPs were separated from a tomato soup. Two potential sample preparation methods were tested these being acid digestion and colloidal extraction. With the developed method a complete SiO2-ENPs and matrix separation with a Si mass recovery >90% was achieved by acid digestion. The alteration of the particle size distribution was minimized by particle stabilization. The generic procedure which also provides quality criteria for method development is urgently needed for standardized and systematic development of procedures for separation of ENPs from a complex matrix. The chosen analytical technique was shown to be suitable for detecting SiO2-ENPs in a complex food matrix like tomato soup and may therefore be extended to monitor the existence of ENPs during production and safety control of foodstuffs, food labelling, and compliance with legislative limits. |
format |
article |
topic_facet |
U30 - Méthodes de recherche 000 - Autres thèmes technique analytique propriété physicochimique législation alimentaire nanoparticules http://aims.fao.org/aos/agrovoc/c_1513 http://aims.fao.org/aos/agrovoc/c_1521 http://aims.fao.org/aos/agrovoc/c_28695 http://aims.fao.org/aos/agrovoc/c_93f051ee |
author |
Wagner, Stephan Legros, Samuel Loeschner, Katrin Liu, Junfeng Navratilova, Jana Grombe, Ringo Linsinger, T.P.J. Larsen, Erik H. Von der Kammer, Frank Hofmann, Thilo |
author_facet |
Wagner, Stephan Legros, Samuel Loeschner, Katrin Liu, Junfeng Navratilova, Jana Grombe, Ringo Linsinger, T.P.J. Larsen, Erik H. Von der Kammer, Frank Hofmann, Thilo |
author_sort |
Wagner, Stephan |
title |
First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS |
title_short |
First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS |
title_full |
First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS |
title_fullStr |
First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS |
title_full_unstemmed |
First steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and ICP-MS |
title_sort |
first steps towards a generic sample preparation scheme for inorganic engineered nanoparticles in a complex matrix for detection, characterization, and quantification by asymmetric flow-field flow fractionation coupled to multi-angle light scattering and icp-ms |
url |
http://agritrop.cirad.fr/578434/ http://agritrop.cirad.fr/578434/1/Wagner%20et%20al%20JAAS%202015.pdf |
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