The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.

Bibliographic Details

Main Authors:	Cociancich, Stéphane, Pesic, Alexander, Petras, Daniel, Uhlmann, Stefanie, Kretz, Julian, Schubert, Vivien, Vieweg, Laura, Duplan, Sandrine, Marguerettaz, Mélanie, Noëll, Julie, Pieretti, Isabelle, Hügelland, Manuela, Kemper, Sebastien, Mainz, Andi, Rott, Philippe, Royer, Monique, Süssmuth, Roderich
Format:	article biblioteca
Language:	eng
Subjects:	000 - Autres thèmes, H20 - Maladies des plantes, toxine bactérienne, Xanthomonas albilineans, structure chimique, biosynthèse, bactéricide, Saccharum officinarum, http://aims.fao.org/aos/agrovoc/c_9047, http://aims.fao.org/aos/agrovoc/c_27422, http://aims.fao.org/aos/agrovoc/c_15893, http://aims.fao.org/aos/agrovoc/c_928, http://aims.fao.org/aos/agrovoc/c_9048, http://aims.fao.org/aos/agrovoc/c_6727,
Online Access:	http://agritrop.cirad.fr/575585/ http://agritrop.cirad.fr/575585/1/document_575585.pdf
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