Potential shortfall of pyramided transgenic cotton for insect resistance management
To delay evolution of pest resistance to transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt), the "pyramid" strategy uses plants that produce two or more toxins that kill the same pest. In the United States, this strategy has been adopted widely, with two-toxin Bt cotton replacing one-toxin Bt cotton. Although two-toxin plants are likely to be more durable than one-toxin plants, the extent of this advantage depends on several conditions. One key assumption favoring success of two-toxin plants is that they kill insects selected for resistance to one toxin, which is called "redundant killing." Here we tested this assumption for a major pest, Helicoverpa zea, on transgenic cotton producing Bt toxins Cry1Ac and Cry2Ab. Selection with Cry1Ac increased survival on two-toxin cotton, which contradicts the assumption. The concentration of Cry1Ac and Cry2Ab declined during the growing season, which would tend to exacerbate this problem. Furthermore, analysis of results from 21 selection experiments with eight species of lepidopteran pests indicates that some cross-resistance typically occurs between Cry1A and Cry2A toxins. Incorporation of empirical data into simulation models shows that the observed deviations from ideal conditions could greatly reduce the benefits of the pyramid strategy for pests like H. zea, which have inherently low susceptibility to Bt toxins and have been exposed extensively to one of the toxins in the pyramid before two-toxin plants are adopted. For such pests, the pyramid strategy could be improved by incorporating empirical data on deviations from ideal assumptions about redundant killing and cross-resistance.
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Language: | eng |
Subjects: | F30 - Génétique et amélioration des plantes, H10 - Ravageurs des plantes, Gossypium, protéine bactérienne, biopesticide, résistance aux organismes nuisibles, plante transgénique, génie génétique, Bacillus thuringiensis, toxine bactérienne, Helicoverpa zea, tolérance aux ravageurs, http://aims.fao.org/aos/agrovoc/c_3335, http://aims.fao.org/aos/agrovoc/c_24141, http://aims.fao.org/aos/agrovoc/c_27467, http://aims.fao.org/aos/agrovoc/c_5731, http://aims.fao.org/aos/agrovoc/c_27619, http://aims.fao.org/aos/agrovoc/c_15974, http://aims.fao.org/aos/agrovoc/c_761, http://aims.fao.org/aos/agrovoc/c_9047, http://aims.fao.org/aos/agrovoc/c_30256, http://aims.fao.org/aos/agrovoc/c_14918, http://aims.fao.org/aos/agrovoc/c_615, |
Online Access: | http://agritrop.cirad.fr/569158/ http://agritrop.cirad.fr/569158/1/document_569158.pdf |
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dig-cirad-fr-5691582024-01-28T21:25:01Z http://agritrop.cirad.fr/569158/ http://agritrop.cirad.fr/569158/ Potential shortfall of pyramided transgenic cotton for insect resistance management. Brévault Thierry, Heuberger Shannon, Zhang Min, Ellers-Kirk Christa, Ni Xinzhi, Masson Luke, Li Xianchiun, Tabashnik Bruce E., Carrière Yves. 2013. Proceedings of the National Academy of Sciences of the United States of America, 110 (15) : 5806-5811.https://doi.org/10.1073/pnas.1216719110 <https://doi.org/10.1073/pnas.1216719110> Potential shortfall of pyramided transgenic cotton for insect resistance management Brévault, Thierry Heuberger, Shannon Zhang, Min Ellers-Kirk, Christa Ni, Xinzhi Masson, Luke Li, Xianchiun Tabashnik, Bruce E. Carrière, Yves eng 2013 Proceedings of the National Academy of Sciences of the United States of America F30 - Génétique et amélioration des plantes H10 - Ravageurs des plantes Gossypium protéine bactérienne biopesticide résistance aux organismes nuisibles plante transgénique génie génétique Bacillus thuringiensis toxine bactérienne Helicoverpa zea tolérance aux ravageurs http://aims.fao.org/aos/agrovoc/c_3335 http://aims.fao.org/aos/agrovoc/c_24141 http://aims.fao.org/aos/agrovoc/c_27467 http://aims.fao.org/aos/agrovoc/c_5731 http://aims.fao.org/aos/agrovoc/c_27619 http://aims.fao.org/aos/agrovoc/c_15974 http://aims.fao.org/aos/agrovoc/c_761 http://aims.fao.org/aos/agrovoc/c_9047 http://aims.fao.org/aos/agrovoc/c_30256 http://aims.fao.org/aos/agrovoc/c_14918 Arizona http://aims.fao.org/aos/agrovoc/c_615 To delay evolution of pest resistance to transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt), the "pyramid" strategy uses plants that produce two or more toxins that kill the same pest. In the United States, this strategy has been adopted widely, with two-toxin Bt cotton replacing one-toxin Bt cotton. Although two-toxin plants are likely to be more durable than one-toxin plants, the extent of this advantage depends on several conditions. One key assumption favoring success of two-toxin plants is that they kill insects selected for resistance to one toxin, which is called "redundant killing." Here we tested this assumption for a major pest, Helicoverpa zea, on transgenic cotton producing Bt toxins Cry1Ac and Cry2Ab. Selection with Cry1Ac increased survival on two-toxin cotton, which contradicts the assumption. The concentration of Cry1Ac and Cry2Ab declined during the growing season, which would tend to exacerbate this problem. Furthermore, analysis of results from 21 selection experiments with eight species of lepidopteran pests indicates that some cross-resistance typically occurs between Cry1A and Cry2A toxins. Incorporation of empirical data into simulation models shows that the observed deviations from ideal conditions could greatly reduce the benefits of the pyramid strategy for pests like H. zea, which have inherently low susceptibility to Bt toxins and have been exposed extensively to one of the toxins in the pyramid before two-toxin plants are adopted. For such pests, the pyramid strategy could be improved by incorporating empirical data on deviations from ideal assumptions about redundant killing and cross-resistance. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/569158/1/document_569158.pdf application/pdf Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1073/pnas.1216719110 10.1073/pnas.1216719110 info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1216719110 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1073/pnas.1216719110 |
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F30 - Génétique et amélioration des plantes H10 - Ravageurs des plantes Gossypium protéine bactérienne biopesticide résistance aux organismes nuisibles plante transgénique génie génétique Bacillus thuringiensis toxine bactérienne Helicoverpa zea tolérance aux ravageurs http://aims.fao.org/aos/agrovoc/c_3335 http://aims.fao.org/aos/agrovoc/c_24141 http://aims.fao.org/aos/agrovoc/c_27467 http://aims.fao.org/aos/agrovoc/c_5731 http://aims.fao.org/aos/agrovoc/c_27619 http://aims.fao.org/aos/agrovoc/c_15974 http://aims.fao.org/aos/agrovoc/c_761 http://aims.fao.org/aos/agrovoc/c_9047 http://aims.fao.org/aos/agrovoc/c_30256 http://aims.fao.org/aos/agrovoc/c_14918 http://aims.fao.org/aos/agrovoc/c_615 F30 - Génétique et amélioration des plantes H10 - Ravageurs des plantes Gossypium protéine bactérienne biopesticide résistance aux organismes nuisibles plante transgénique génie génétique Bacillus thuringiensis toxine bactérienne Helicoverpa zea tolérance aux ravageurs http://aims.fao.org/aos/agrovoc/c_3335 http://aims.fao.org/aos/agrovoc/c_24141 http://aims.fao.org/aos/agrovoc/c_27467 http://aims.fao.org/aos/agrovoc/c_5731 http://aims.fao.org/aos/agrovoc/c_27619 http://aims.fao.org/aos/agrovoc/c_15974 http://aims.fao.org/aos/agrovoc/c_761 http://aims.fao.org/aos/agrovoc/c_9047 http://aims.fao.org/aos/agrovoc/c_30256 http://aims.fao.org/aos/agrovoc/c_14918 http://aims.fao.org/aos/agrovoc/c_615 |
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F30 - Génétique et amélioration des plantes H10 - Ravageurs des plantes Gossypium protéine bactérienne biopesticide résistance aux organismes nuisibles plante transgénique génie génétique Bacillus thuringiensis toxine bactérienne Helicoverpa zea tolérance aux ravageurs http://aims.fao.org/aos/agrovoc/c_3335 http://aims.fao.org/aos/agrovoc/c_24141 http://aims.fao.org/aos/agrovoc/c_27467 http://aims.fao.org/aos/agrovoc/c_5731 http://aims.fao.org/aos/agrovoc/c_27619 http://aims.fao.org/aos/agrovoc/c_15974 http://aims.fao.org/aos/agrovoc/c_761 http://aims.fao.org/aos/agrovoc/c_9047 http://aims.fao.org/aos/agrovoc/c_30256 http://aims.fao.org/aos/agrovoc/c_14918 http://aims.fao.org/aos/agrovoc/c_615 F30 - Génétique et amélioration des plantes H10 - Ravageurs des plantes Gossypium protéine bactérienne biopesticide résistance aux organismes nuisibles plante transgénique génie génétique Bacillus thuringiensis toxine bactérienne Helicoverpa zea tolérance aux ravageurs http://aims.fao.org/aos/agrovoc/c_3335 http://aims.fao.org/aos/agrovoc/c_24141 http://aims.fao.org/aos/agrovoc/c_27467 http://aims.fao.org/aos/agrovoc/c_5731 http://aims.fao.org/aos/agrovoc/c_27619 http://aims.fao.org/aos/agrovoc/c_15974 http://aims.fao.org/aos/agrovoc/c_761 http://aims.fao.org/aos/agrovoc/c_9047 http://aims.fao.org/aos/agrovoc/c_30256 http://aims.fao.org/aos/agrovoc/c_14918 http://aims.fao.org/aos/agrovoc/c_615 Brévault, Thierry Heuberger, Shannon Zhang, Min Ellers-Kirk, Christa Ni, Xinzhi Masson, Luke Li, Xianchiun Tabashnik, Bruce E. Carrière, Yves Potential shortfall of pyramided transgenic cotton for insect resistance management |
description |
To delay evolution of pest resistance to transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt), the "pyramid" strategy uses plants that produce two or more toxins that kill the same pest. In the United States, this strategy has been adopted widely, with two-toxin Bt cotton replacing one-toxin Bt cotton. Although two-toxin plants are likely to be more durable than one-toxin plants, the extent of this advantage depends on several conditions. One key assumption favoring success of two-toxin plants is that they kill insects selected for resistance to one toxin, which is called "redundant killing." Here we tested this assumption for a major pest, Helicoverpa zea, on transgenic cotton producing Bt toxins Cry1Ac and Cry2Ab. Selection with Cry1Ac increased survival on two-toxin cotton, which contradicts the assumption. The concentration of Cry1Ac and Cry2Ab declined during the growing season, which would tend to exacerbate this problem. Furthermore, analysis of results from 21 selection experiments with eight species of lepidopteran pests indicates that some cross-resistance typically occurs between Cry1A and Cry2A toxins. Incorporation of empirical data into simulation models shows that the observed deviations from ideal conditions could greatly reduce the benefits of the pyramid strategy for pests like H. zea, which have inherently low susceptibility to Bt toxins and have been exposed extensively to one of the toxins in the pyramid before two-toxin plants are adopted. For such pests, the pyramid strategy could be improved by incorporating empirical data on deviations from ideal assumptions about redundant killing and cross-resistance. |
format |
article |
topic_facet |
F30 - Génétique et amélioration des plantes H10 - Ravageurs des plantes Gossypium protéine bactérienne biopesticide résistance aux organismes nuisibles plante transgénique génie génétique Bacillus thuringiensis toxine bactérienne Helicoverpa zea tolérance aux ravageurs http://aims.fao.org/aos/agrovoc/c_3335 http://aims.fao.org/aos/agrovoc/c_24141 http://aims.fao.org/aos/agrovoc/c_27467 http://aims.fao.org/aos/agrovoc/c_5731 http://aims.fao.org/aos/agrovoc/c_27619 http://aims.fao.org/aos/agrovoc/c_15974 http://aims.fao.org/aos/agrovoc/c_761 http://aims.fao.org/aos/agrovoc/c_9047 http://aims.fao.org/aos/agrovoc/c_30256 http://aims.fao.org/aos/agrovoc/c_14918 http://aims.fao.org/aos/agrovoc/c_615 |
author |
Brévault, Thierry Heuberger, Shannon Zhang, Min Ellers-Kirk, Christa Ni, Xinzhi Masson, Luke Li, Xianchiun Tabashnik, Bruce E. Carrière, Yves |
author_facet |
Brévault, Thierry Heuberger, Shannon Zhang, Min Ellers-Kirk, Christa Ni, Xinzhi Masson, Luke Li, Xianchiun Tabashnik, Bruce E. Carrière, Yves |
author_sort |
Brévault, Thierry |
title |
Potential shortfall of pyramided transgenic cotton for insect resistance management |
title_short |
Potential shortfall of pyramided transgenic cotton for insect resistance management |
title_full |
Potential shortfall of pyramided transgenic cotton for insect resistance management |
title_fullStr |
Potential shortfall of pyramided transgenic cotton for insect resistance management |
title_full_unstemmed |
Potential shortfall of pyramided transgenic cotton for insect resistance management |
title_sort |
potential shortfall of pyramided transgenic cotton for insect resistance management |
url |
http://agritrop.cirad.fr/569158/ http://agritrop.cirad.fr/569158/1/document_569158.pdf |
work_keys_str_mv |
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