Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia
Rodent control is an important issue in human health and agriculture. Oil palm plantations are rapidly expanding in Indonesia and this is having a major economic and ecological impact. Rodent control in oil palm plantations is based principally on the use of anti-vitamin K (AVK), the main anticoagulant used being coumatetralyl, a first-generation AVK. We conducted a comparative study in two well established oil palm plantations in Indonesia: (1) one without chemical control in Riau and (2) another with intensive coumatetralyl use on Bangka Island. Rat species were identified by the molecular barcoding method. Susceptibility to coumatetralyl was then assessed within the two populations and we screened for mutations in vkorc1, which encodes the molecular target of AVK. Different species were found in the two areas: Rattus tiomanicus in Riau, and a mix of R. tanezumi and a close relative one in Bangka. The rats in Riau were much more susceptible to coumatetralyl than those in Bangka. This study is the first to demonstrate physiological tolerance to AVK in these species. vkorc1 displayed low levels of polymorphism, and no SNP was associated with the hightolerance phenotypes of R. tanezumi clade, even those exposed to very high concentrations (32 9 the effective dose of 0.36 mg kg-1). The biochemical basis of this tolerance remains unknown, but may involve the vkorc1 promoter and/or cytochrome P450 metabolism. We discuss our results and the selective role of anticoagulant use in the occurrence of phenotypic tolerance.
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Subjects: | H10 - Ravageurs des plantes, Elaeis guineensis, rat, lutte antirongeur, rodenticide, antivitamine, anticoagulant, résistance aux pesticides, http://aims.fao.org/aos/agrovoc/c_2509, http://aims.fao.org/aos/agrovoc/c_6464, http://aims.fao.org/aos/agrovoc/c_6631, http://aims.fao.org/aos/agrovoc/c_6632, http://aims.fao.org/aos/agrovoc/c_515, http://aims.fao.org/aos/agrovoc/c_496, http://aims.fao.org/aos/agrovoc/c_25427, http://aims.fao.org/aos/agrovoc/c_3840, http://aims.fao.org/aos/agrovoc/c_7260, |
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dig-cirad-fr-5677922024-01-28T21:13:19Z http://agritrop.cirad.fr/567792/ http://agritrop.cirad.fr/567792/ Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia. Andru Julie, Cosson Jean François, Caliman Jean-Pierre, Benoit Etienne. 2013. Ecotoxicology, 22 (2) : 377-386.https://doi.org/10.1007/s10646-012-1032-y <https://doi.org/10.1007/s10646-012-1032-y> Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia Andru, Julie Cosson, Jean François Caliman, Jean-Pierre Benoit, Etienne eng 2013 Ecotoxicology H10 - Ravageurs des plantes Elaeis guineensis rat lutte antirongeur rodenticide antivitamine anticoagulant résistance aux pesticides http://aims.fao.org/aos/agrovoc/c_2509 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_6631 http://aims.fao.org/aos/agrovoc/c_6632 http://aims.fao.org/aos/agrovoc/c_515 http://aims.fao.org/aos/agrovoc/c_496 http://aims.fao.org/aos/agrovoc/c_25427 Indonésie Asie du Sud-Est http://aims.fao.org/aos/agrovoc/c_3840 http://aims.fao.org/aos/agrovoc/c_7260 Rodent control is an important issue in human health and agriculture. Oil palm plantations are rapidly expanding in Indonesia and this is having a major economic and ecological impact. Rodent control in oil palm plantations is based principally on the use of anti-vitamin K (AVK), the main anticoagulant used being coumatetralyl, a first-generation AVK. We conducted a comparative study in two well established oil palm plantations in Indonesia: (1) one without chemical control in Riau and (2) another with intensive coumatetralyl use on Bangka Island. Rat species were identified by the molecular barcoding method. Susceptibility to coumatetralyl was then assessed within the two populations and we screened for mutations in vkorc1, which encodes the molecular target of AVK. Different species were found in the two areas: Rattus tiomanicus in Riau, and a mix of R. tanezumi and a close relative one in Bangka. The rats in Riau were much more susceptible to coumatetralyl than those in Bangka. This study is the first to demonstrate physiological tolerance to AVK in these species. vkorc1 displayed low levels of polymorphism, and no SNP was associated with the hightolerance phenotypes of R. tanezumi clade, even those exposed to very high concentrations (32 9 the effective dose of 0.36 mg kg-1). The biochemical basis of this tolerance remains unknown, but may involve the vkorc1 promoter and/or cytochrome P450 metabolism. We discuss our results and the selective role of anticoagulant use in the occurrence of phenotypic tolerance. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/567792/1/document_567792.pdf application/pdf Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1007/s10646-012-1032-y 10.1007/s10646-012-1032-y info:eu-repo/semantics/altIdentifier/doi/10.1007/s10646-012-1032-y info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1007/s10646-012-1032-y |
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H10 - Ravageurs des plantes Elaeis guineensis rat lutte antirongeur rodenticide antivitamine anticoagulant résistance aux pesticides http://aims.fao.org/aos/agrovoc/c_2509 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_6631 http://aims.fao.org/aos/agrovoc/c_6632 http://aims.fao.org/aos/agrovoc/c_515 http://aims.fao.org/aos/agrovoc/c_496 http://aims.fao.org/aos/agrovoc/c_25427 http://aims.fao.org/aos/agrovoc/c_3840 http://aims.fao.org/aos/agrovoc/c_7260 H10 - Ravageurs des plantes Elaeis guineensis rat lutte antirongeur rodenticide antivitamine anticoagulant résistance aux pesticides http://aims.fao.org/aos/agrovoc/c_2509 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_6631 http://aims.fao.org/aos/agrovoc/c_6632 http://aims.fao.org/aos/agrovoc/c_515 http://aims.fao.org/aos/agrovoc/c_496 http://aims.fao.org/aos/agrovoc/c_25427 http://aims.fao.org/aos/agrovoc/c_3840 http://aims.fao.org/aos/agrovoc/c_7260 |
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H10 - Ravageurs des plantes Elaeis guineensis rat lutte antirongeur rodenticide antivitamine anticoagulant résistance aux pesticides http://aims.fao.org/aos/agrovoc/c_2509 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_6631 http://aims.fao.org/aos/agrovoc/c_6632 http://aims.fao.org/aos/agrovoc/c_515 http://aims.fao.org/aos/agrovoc/c_496 http://aims.fao.org/aos/agrovoc/c_25427 http://aims.fao.org/aos/agrovoc/c_3840 http://aims.fao.org/aos/agrovoc/c_7260 H10 - Ravageurs des plantes Elaeis guineensis rat lutte antirongeur rodenticide antivitamine anticoagulant résistance aux pesticides http://aims.fao.org/aos/agrovoc/c_2509 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_6631 http://aims.fao.org/aos/agrovoc/c_6632 http://aims.fao.org/aos/agrovoc/c_515 http://aims.fao.org/aos/agrovoc/c_496 http://aims.fao.org/aos/agrovoc/c_25427 http://aims.fao.org/aos/agrovoc/c_3840 http://aims.fao.org/aos/agrovoc/c_7260 Andru, Julie Cosson, Jean François Caliman, Jean-Pierre Benoit, Etienne Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia |
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Rodent control is an important issue in human health and agriculture. Oil palm plantations are rapidly expanding in Indonesia and this is having a major economic and ecological impact. Rodent control in oil palm plantations is based principally on the use of anti-vitamin K (AVK), the main anticoagulant used being coumatetralyl, a first-generation AVK. We conducted a comparative study in two well established oil palm plantations in Indonesia: (1) one without chemical control in Riau and (2) another with intensive coumatetralyl use on Bangka Island. Rat species were identified by the molecular barcoding method. Susceptibility to coumatetralyl was then assessed within the two populations and we screened for mutations in vkorc1, which encodes the molecular target of AVK. Different species were found in the two areas: Rattus tiomanicus in Riau, and a mix of R. tanezumi and a close relative one in Bangka. The rats in Riau were much more susceptible to coumatetralyl than those in Bangka. This study is the first to demonstrate physiological tolerance to AVK in these species. vkorc1 displayed low levels of polymorphism, and no SNP was associated with the hightolerance phenotypes of R. tanezumi clade, even those exposed to very high concentrations (32 9 the effective dose of 0.36 mg kg-1). The biochemical basis of this tolerance remains unknown, but may involve the vkorc1 promoter and/or cytochrome P450 metabolism. We discuss our results and the selective role of anticoagulant use in the occurrence of phenotypic tolerance. |
format |
article |
topic_facet |
H10 - Ravageurs des plantes Elaeis guineensis rat lutte antirongeur rodenticide antivitamine anticoagulant résistance aux pesticides http://aims.fao.org/aos/agrovoc/c_2509 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_6631 http://aims.fao.org/aos/agrovoc/c_6632 http://aims.fao.org/aos/agrovoc/c_515 http://aims.fao.org/aos/agrovoc/c_496 http://aims.fao.org/aos/agrovoc/c_25427 http://aims.fao.org/aos/agrovoc/c_3840 http://aims.fao.org/aos/agrovoc/c_7260 |
author |
Andru, Julie Cosson, Jean François Caliman, Jean-Pierre Benoit, Etienne |
author_facet |
Andru, Julie Cosson, Jean François Caliman, Jean-Pierre Benoit, Etienne |
author_sort |
Andru, Julie |
title |
Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia |
title_short |
Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia |
title_full |
Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia |
title_fullStr |
Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia |
title_full_unstemmed |
Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia |
title_sort |
coumatetralyl resistance of rattus tanezumi infesting oil palm plantations in indonesia |
url |
http://agritrop.cirad.fr/567792/ http://agritrop.cirad.fr/567792/1/document_567792.pdf |
work_keys_str_mv |
AT andrujulie coumatetralylresistanceofrattustanezumiinfestingoilpalmplantationsinindonesia AT cossonjeanfrancois coumatetralylresistanceofrattustanezumiinfestingoilpalmplantationsinindonesia AT calimanjeanpierre coumatetralylresistanceofrattustanezumiinfestingoilpalmplantationsinindonesia AT benoitetienne coumatetralylresistanceofrattustanezumiinfestingoilpalmplantationsinindonesia |
_version_ |
1792498406705332224 |