Can human movements explain heterogeneous propagation of dengue fever in Cambodia?
Background: Determining the factors underlying the long-range spatial spread of infectious diseases is a key issue regarding their control. Dengue is the most important arboviral disease worldwide and a major public health problem in tropical areas. However the determinants shaping its dynamics at a national scale remain poorly understood. Here we describe the spatial-temporal pattern of propagation of annual epidemics in Cambodia and discuss the role that human movements play in the observed pattern. Methods and Findings: We used wavelet phase analysis to analyse time-series data of 105,598 hospitalized cases reported between 2002 and 2008 in the 135 (/180) most populous districts in Cambodia. We reveal spatial heterogeneity in the propagation of the annual epidemic. Each year, epidemics are highly synchronous over a large geographic area along the busiest national road of the country whereas travelling waves emanate from a few rural areas and move slowly along the Mekong River at a speed of ,11 km per week (95% confidence interval 3-18 km per week) towards the capital, Phnom Penh. Conclusions: We suggest human movements - using roads as a surrogate - play a major role in the spread of dengue fever at a national scale. These findings constitute a new starting point in the understanding of the processes driving dengue spread.
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Language: | eng |
Subjects: | L73 - Maladies des animaux, E51 - Population rurale, flavivirus, transmission des maladies, migration, genre humain, http://aims.fao.org/aos/agrovoc/c_2963, http://aims.fao.org/aos/agrovoc/c_2329, http://aims.fao.org/aos/agrovoc/c_4822, http://aims.fao.org/aos/agrovoc/c_4586, http://aims.fao.org/aos/agrovoc/c_4073, |
Online Access: | http://agritrop.cirad.fr/567015/ http://agritrop.cirad.fr/567015/1/document_567015.pdf |
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dig-cirad-fr-5670152024-01-28T21:04:32Z http://agritrop.cirad.fr/567015/ http://agritrop.cirad.fr/567015/ Can human movements explain heterogeneous propagation of dengue fever in Cambodia? Teurlai Magali, Huy Rekol, Cazelles Bernard, Duboz Raphaël, Baehr Christophe, Vong Sirenda. 2012. PLoS Neglected Tropical Diseases, 6 (12):e1957, 8 p.https://doi.org/10.1371/journal.pntd.0001957 <https://doi.org/10.1371/journal.pntd.0001957> Can human movements explain heterogeneous propagation of dengue fever in Cambodia? Teurlai, Magali Huy, Rekol Cazelles, Bernard Duboz, Raphaël Baehr, Christophe Vong, Sirenda eng 2012 PLoS Neglected Tropical Diseases L73 - Maladies des animaux E51 - Population rurale flavivirus transmission des maladies migration genre humain http://aims.fao.org/aos/agrovoc/c_2963 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_4822 http://aims.fao.org/aos/agrovoc/c_4586 Cambodge http://aims.fao.org/aos/agrovoc/c_4073 Background: Determining the factors underlying the long-range spatial spread of infectious diseases is a key issue regarding their control. Dengue is the most important arboviral disease worldwide and a major public health problem in tropical areas. However the determinants shaping its dynamics at a national scale remain poorly understood. Here we describe the spatial-temporal pattern of propagation of annual epidemics in Cambodia and discuss the role that human movements play in the observed pattern. Methods and Findings: We used wavelet phase analysis to analyse time-series data of 105,598 hospitalized cases reported between 2002 and 2008 in the 135 (/180) most populous districts in Cambodia. We reveal spatial heterogeneity in the propagation of the annual epidemic. Each year, epidemics are highly synchronous over a large geographic area along the busiest national road of the country whereas travelling waves emanate from a few rural areas and move slowly along the Mekong River at a speed of ,11 km per week (95% confidence interval 3-18 km per week) towards the capital, Phnom Penh. Conclusions: We suggest human movements - using roads as a surrogate - play a major role in the spread of dengue fever at a national scale. These findings constitute a new starting point in the understanding of the processes driving dengue spread. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/567015/1/document_567015.pdf application/pdf Cirad license info:eu-repo/semantics/openAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1371/journal.pntd.0001957 10.1371/journal.pntd.0001957 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0001957 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1371/journal.pntd.0001957 |
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L73 - Maladies des animaux E51 - Population rurale flavivirus transmission des maladies migration genre humain http://aims.fao.org/aos/agrovoc/c_2963 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_4822 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4073 L73 - Maladies des animaux E51 - Population rurale flavivirus transmission des maladies migration genre humain http://aims.fao.org/aos/agrovoc/c_2963 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_4822 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4073 |
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L73 - Maladies des animaux E51 - Population rurale flavivirus transmission des maladies migration genre humain http://aims.fao.org/aos/agrovoc/c_2963 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_4822 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4073 L73 - Maladies des animaux E51 - Population rurale flavivirus transmission des maladies migration genre humain http://aims.fao.org/aos/agrovoc/c_2963 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_4822 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4073 Teurlai, Magali Huy, Rekol Cazelles, Bernard Duboz, Raphaël Baehr, Christophe Vong, Sirenda Can human movements explain heterogeneous propagation of dengue fever in Cambodia? |
description |
Background: Determining the factors underlying the long-range spatial spread of infectious diseases is a key issue regarding their control. Dengue is the most important arboviral disease worldwide and a major public health problem in tropical areas. However the determinants shaping its dynamics at a national scale remain poorly understood. Here we describe the spatial-temporal pattern of propagation of annual epidemics in Cambodia and discuss the role that human movements play in the observed pattern. Methods and Findings: We used wavelet phase analysis to analyse time-series data of 105,598 hospitalized cases reported between 2002 and 2008 in the 135 (/180) most populous districts in Cambodia. We reveal spatial heterogeneity in the propagation of the annual epidemic. Each year, epidemics are highly synchronous over a large geographic area along the busiest national road of the country whereas travelling waves emanate from a few rural areas and move slowly along the Mekong River at a speed of ,11 km per week (95% confidence interval 3-18 km per week) towards the capital, Phnom Penh. Conclusions: We suggest human movements - using roads as a surrogate - play a major role in the spread of dengue fever at a national scale. These findings constitute a new starting point in the understanding of the processes driving dengue spread. |
format |
article |
topic_facet |
L73 - Maladies des animaux E51 - Population rurale flavivirus transmission des maladies migration genre humain http://aims.fao.org/aos/agrovoc/c_2963 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_4822 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4073 |
author |
Teurlai, Magali Huy, Rekol Cazelles, Bernard Duboz, Raphaël Baehr, Christophe Vong, Sirenda |
author_facet |
Teurlai, Magali Huy, Rekol Cazelles, Bernard Duboz, Raphaël Baehr, Christophe Vong, Sirenda |
author_sort |
Teurlai, Magali |
title |
Can human movements explain heterogeneous propagation of dengue fever in Cambodia? |
title_short |
Can human movements explain heterogeneous propagation of dengue fever in Cambodia? |
title_full |
Can human movements explain heterogeneous propagation of dengue fever in Cambodia? |
title_fullStr |
Can human movements explain heterogeneous propagation of dengue fever in Cambodia? |
title_full_unstemmed |
Can human movements explain heterogeneous propagation of dengue fever in Cambodia? |
title_sort |
can human movements explain heterogeneous propagation of dengue fever in cambodia? |
url |
http://agritrop.cirad.fr/567015/ http://agritrop.cirad.fr/567015/1/document_567015.pdf |
work_keys_str_mv |
AT teurlaimagali canhumanmovementsexplainheterogeneouspropagationofdenguefeverincambodia AT huyrekol canhumanmovementsexplainheterogeneouspropagationofdenguefeverincambodia AT cazellesbernard canhumanmovementsexplainheterogeneouspropagationofdenguefeverincambodia AT dubozraphael canhumanmovementsexplainheterogeneouspropagationofdenguefeverincambodia AT baehrchristophe canhumanmovementsexplainheterogeneouspropagationofdenguefeverincambodia AT vongsirenda canhumanmovementsexplainheterogeneouspropagationofdenguefeverincambodia |
_version_ |
1792498366168432640 |