Influence of risk factors on renal leptospiral load in naturally infected wild black rats
In 2009, a survey was conducted in Reunion Island to determine the renal leptospiral load in black rats trapped in the field. The concentration of leptospires in kidney tissue was calculated using qPCR. Our results showed high inter-individual variations of renal bacterial load in naturally infected black rats (mean = 8.27 ± 4.72 log-genome copies per mg kidney tissue). The objective of this study was to model the renal leptospiral load in 50 naturally infected black rats as a function of sex, age, and weight. Statistical analysis by sex showed that, in naturally infected males, the renal leptospiral load was correlated with weight (p-value = 0.032). Moreover, our model showed that weight and sex were significant explanatory variables for the renal leptospiral load in naturally infected young black rats (R2 = 0.953). Laboratory experimentation could not replicate naturally acquired infection, but field studies also present many limitations. Our study is the first attempt to explain individual variations in the renal leptospiral load in naturally infected reservoir animals but further research is needed.
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Subjects: | L73 - Maladies des animaux, S50 - Santé humaine, leptospirose, infection, modèle de simulation, rat, genre humain, rein, PCR, sexe, poids, âge, http://aims.fao.org/aos/agrovoc/c_4281, http://aims.fao.org/aos/agrovoc/c_3852, http://aims.fao.org/aos/agrovoc/c_24242, http://aims.fao.org/aos/agrovoc/c_6464, http://aims.fao.org/aos/agrovoc/c_4586, http://aims.fao.org/aos/agrovoc/c_4099, http://aims.fao.org/aos/agrovoc/c_34079, http://aims.fao.org/aos/agrovoc/c_7010, http://aims.fao.org/aos/agrovoc/c_8349, http://aims.fao.org/aos/agrovoc/c_186, http://aims.fao.org/aos/agrovoc/c_6543, http://aims.fao.org/aos/agrovoc/c_3081, |
Online Access: | http://agritrop.cirad.fr/566796/ http://agritrop.cirad.fr/566796/1/document_566796.pdf |
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dig-cirad-fr-5667962024-01-28T21:00:56Z http://agritrop.cirad.fr/566796/ http://agritrop.cirad.fr/566796/ Influence of risk factors on renal leptospiral load in naturally infected wild black rats. Desvars Amélie, Michault Alain, Chiroleu Frédéric. 2013. Acta Tropica, 125 (3) : 258-261.https://doi.org/10.1016/j.actatropica.2012.11.011 <https://doi.org/10.1016/j.actatropica.2012.11.011> Influence of risk factors on renal leptospiral load in naturally infected wild black rats Desvars, Amélie Michault, Alain Chiroleu, Frédéric eng 2013 Acta Tropica L73 - Maladies des animaux S50 - Santé humaine leptospirose infection modèle de simulation rat genre humain rein PCR sexe poids âge http://aims.fao.org/aos/agrovoc/c_4281 http://aims.fao.org/aos/agrovoc/c_3852 http://aims.fao.org/aos/agrovoc/c_24242 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4099 http://aims.fao.org/aos/agrovoc/c_34079 http://aims.fao.org/aos/agrovoc/c_7010 http://aims.fao.org/aos/agrovoc/c_8349 http://aims.fao.org/aos/agrovoc/c_186 La Réunion France http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 In 2009, a survey was conducted in Reunion Island to determine the renal leptospiral load in black rats trapped in the field. The concentration of leptospires in kidney tissue was calculated using qPCR. Our results showed high inter-individual variations of renal bacterial load in naturally infected black rats (mean = 8.27 ± 4.72 log-genome copies per mg kidney tissue). The objective of this study was to model the renal leptospiral load in 50 naturally infected black rats as a function of sex, age, and weight. Statistical analysis by sex showed that, in naturally infected males, the renal leptospiral load was correlated with weight (p-value = 0.032). Moreover, our model showed that weight and sex were significant explanatory variables for the renal leptospiral load in naturally infected young black rats (R2 = 0.953). Laboratory experimentation could not replicate naturally acquired infection, but field studies also present many limitations. Our study is the first attempt to explain individual variations in the renal leptospiral load in naturally infected reservoir animals but further research is needed. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/566796/1/document_566796.pdf application/pdf Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1016/j.actatropica.2012.11.011 10.1016/j.actatropica.2012.11.011 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actatropica.2012.11.011 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1016/j.actatropica.2012.11.011 |
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L73 - Maladies des animaux S50 - Santé humaine leptospirose infection modèle de simulation rat genre humain rein PCR sexe poids âge http://aims.fao.org/aos/agrovoc/c_4281 http://aims.fao.org/aos/agrovoc/c_3852 http://aims.fao.org/aos/agrovoc/c_24242 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4099 http://aims.fao.org/aos/agrovoc/c_34079 http://aims.fao.org/aos/agrovoc/c_7010 http://aims.fao.org/aos/agrovoc/c_8349 http://aims.fao.org/aos/agrovoc/c_186 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 L73 - Maladies des animaux S50 - Santé humaine leptospirose infection modèle de simulation rat genre humain rein PCR sexe poids âge http://aims.fao.org/aos/agrovoc/c_4281 http://aims.fao.org/aos/agrovoc/c_3852 http://aims.fao.org/aos/agrovoc/c_24242 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4099 http://aims.fao.org/aos/agrovoc/c_34079 http://aims.fao.org/aos/agrovoc/c_7010 http://aims.fao.org/aos/agrovoc/c_8349 http://aims.fao.org/aos/agrovoc/c_186 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 |
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L73 - Maladies des animaux S50 - Santé humaine leptospirose infection modèle de simulation rat genre humain rein PCR sexe poids âge http://aims.fao.org/aos/agrovoc/c_4281 http://aims.fao.org/aos/agrovoc/c_3852 http://aims.fao.org/aos/agrovoc/c_24242 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4099 http://aims.fao.org/aos/agrovoc/c_34079 http://aims.fao.org/aos/agrovoc/c_7010 http://aims.fao.org/aos/agrovoc/c_8349 http://aims.fao.org/aos/agrovoc/c_186 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 L73 - Maladies des animaux S50 - Santé humaine leptospirose infection modèle de simulation rat genre humain rein PCR sexe poids âge http://aims.fao.org/aos/agrovoc/c_4281 http://aims.fao.org/aos/agrovoc/c_3852 http://aims.fao.org/aos/agrovoc/c_24242 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4099 http://aims.fao.org/aos/agrovoc/c_34079 http://aims.fao.org/aos/agrovoc/c_7010 http://aims.fao.org/aos/agrovoc/c_8349 http://aims.fao.org/aos/agrovoc/c_186 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 Desvars, Amélie Michault, Alain Chiroleu, Frédéric Influence of risk factors on renal leptospiral load in naturally infected wild black rats |
description |
In 2009, a survey was conducted in Reunion Island to determine the renal leptospiral load in black rats trapped in the field. The concentration of leptospires in kidney tissue was calculated using qPCR. Our results showed high inter-individual variations of renal bacterial load in naturally infected black rats (mean = 8.27 ± 4.72 log-genome copies per mg kidney tissue). The objective of this study was to model the renal leptospiral load in 50 naturally infected black rats as a function of sex, age, and weight. Statistical analysis by sex showed that, in naturally infected males, the renal leptospiral load was correlated with weight (p-value = 0.032). Moreover, our model showed that weight and sex were significant explanatory variables for the renal leptospiral load in naturally infected young black rats (R2 = 0.953). Laboratory experimentation could not replicate naturally acquired infection, but field studies also present many limitations. Our study is the first attempt to explain individual variations in the renal leptospiral load in naturally infected reservoir animals but further research is needed. |
format |
article |
topic_facet |
L73 - Maladies des animaux S50 - Santé humaine leptospirose infection modèle de simulation rat genre humain rein PCR sexe poids âge http://aims.fao.org/aos/agrovoc/c_4281 http://aims.fao.org/aos/agrovoc/c_3852 http://aims.fao.org/aos/agrovoc/c_24242 http://aims.fao.org/aos/agrovoc/c_6464 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_4099 http://aims.fao.org/aos/agrovoc/c_34079 http://aims.fao.org/aos/agrovoc/c_7010 http://aims.fao.org/aos/agrovoc/c_8349 http://aims.fao.org/aos/agrovoc/c_186 http://aims.fao.org/aos/agrovoc/c_6543 http://aims.fao.org/aos/agrovoc/c_3081 |
author |
Desvars, Amélie Michault, Alain Chiroleu, Frédéric |
author_facet |
Desvars, Amélie Michault, Alain Chiroleu, Frédéric |
author_sort |
Desvars, Amélie |
title |
Influence of risk factors on renal leptospiral load in naturally infected wild black rats |
title_short |
Influence of risk factors on renal leptospiral load in naturally infected wild black rats |
title_full |
Influence of risk factors on renal leptospiral load in naturally infected wild black rats |
title_fullStr |
Influence of risk factors on renal leptospiral load in naturally infected wild black rats |
title_full_unstemmed |
Influence of risk factors on renal leptospiral load in naturally infected wild black rats |
title_sort |
influence of risk factors on renal leptospiral load in naturally infected wild black rats |
url |
http://agritrop.cirad.fr/566796/ http://agritrop.cirad.fr/566796/1/document_566796.pdf |
work_keys_str_mv |
AT desvarsamelie influenceofriskfactorsonrenalleptospiralloadinnaturallyinfectedwildblackrats AT michaultalain influenceofriskfactorsonrenalleptospiralloadinnaturallyinfectedwildblackrats AT chiroleufrederic influenceofriskfactorsonrenalleptospiralloadinnaturallyinfectedwildblackrats |
_version_ |
1792498350981906432 |