The auxin signalling network translates dynamic input into robust patterning at the shoot apex
The plant hormone auxin is thought to provide positional information for patterning during development. It is still unclear, however, precisely how auxin is distributed across tissues and how the hormone is sensed in space and time. The control of gene expression in response to auxin involves a complex network of over 50 potentially interacting transcriptional activators and repressors, the auxin response factors (ARFs) and Aux/IAAs. Here, we perform a large-scale analysis of the Aux/IAA-ARF pathway in the shoot apex of Arabidopsis, where dynamic auxin-based patterning controls organogenesis. A comprehensive expression map and full interactome uncovered an unexpectedly simple distribution and structure of this pathway in the shoot apex. A mathematical model of the Aux/IAA-ARF network predicted a strong buffering capacity along with spatial differences in auxin sensitivity.We then tested and confirmed these predictions using a novel auxin signalling sensor that reports input into the signalling pathway, in conjunction with the published DR5 transcriptional output reporter. Our results provide evidence that the auxin signalling network is essential to create robust patterns at the shoot apex.
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Subjects: | F62 - Physiologie végétale - Croissance et développement, U10 - Informatique, mathématiques et statistiques, développement biologique, auxine, Arabidopsis, http://aims.fao.org/aos/agrovoc/c_921, http://aims.fao.org/aos/agrovoc/c_726, http://aims.fao.org/aos/agrovoc/c_33291, |
Online Access: | http://agritrop.cirad.fr/560833/ http://agritrop.cirad.fr/560833/1/document_560833.pdf |
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dig-cirad-fr-5608332024-01-28T19:25:36Z http://agritrop.cirad.fr/560833/ http://agritrop.cirad.fr/560833/ The auxin signalling network translates dynamic input into robust patterning at the shoot apex. Vernoux Teva, Brunoud Géraldine, Farcot Etienne, Morin Valérie, Van Den Daele Hilde, Legrand Jonathan, Oliva Marina, Das Pradeep, Larrieu Antoine, Wells Darren, Guédon Yann, Armitage Lynne, Picard Franck, Guyomarc'h Soizic, Cellier Coralie, Parry Geraint, Koumproglou Rachil, Doonan John H., Estelle Mark, Godin Christophe, Kepinski Stefan, Bennett Malcolm J., De Veylder Lieven, Traas Jan. 2011. Molecular Systems Biology (7):508, 15 p.https://doi.org/10.1038/msb.2011.39 <https://doi.org/10.1038/msb.2011.39> The auxin signalling network translates dynamic input into robust patterning at the shoot apex Vernoux, Teva Brunoud, Géraldine Farcot, Etienne Morin, Valérie Van Den Daele, Hilde Legrand, Jonathan Oliva, Marina Das, Pradeep Larrieu, Antoine Wells, Darren Guédon, Yann Armitage, Lynne Picard, Franck Guyomarc'h, Soizic Cellier, Coralie Parry, Geraint Koumproglou, Rachil Doonan, John H. Estelle, Mark Godin, Christophe Kepinski, Stefan Bennett, Malcolm J. De Veylder, Lieven Traas, Jan eng 2011 Molecular Systems Biology F62 - Physiologie végétale - Croissance et développement U10 - Informatique, mathématiques et statistiques développement biologique auxine Arabidopsis http://aims.fao.org/aos/agrovoc/c_921 http://aims.fao.org/aos/agrovoc/c_726 http://aims.fao.org/aos/agrovoc/c_33291 The plant hormone auxin is thought to provide positional information for patterning during development. It is still unclear, however, precisely how auxin is distributed across tissues and how the hormone is sensed in space and time. The control of gene expression in response to auxin involves a complex network of over 50 potentially interacting transcriptional activators and repressors, the auxin response factors (ARFs) and Aux/IAAs. Here, we perform a large-scale analysis of the Aux/IAA-ARF pathway in the shoot apex of Arabidopsis, where dynamic auxin-based patterning controls organogenesis. A comprehensive expression map and full interactome uncovered an unexpectedly simple distribution and structure of this pathway in the shoot apex. A mathematical model of the Aux/IAA-ARF network predicted a strong buffering capacity along with spatial differences in auxin sensitivity.We then tested and confirmed these predictions using a novel auxin signalling sensor that reports input into the signalling pathway, in conjunction with the published DR5 transcriptional output reporter. Our results provide evidence that the auxin signalling network is essential to create robust patterns at the shoot apex. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/560833/1/document_560833.pdf application/pdf Cirad license info:eu-repo/semantics/openAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1038/msb.2011.39 10.1038/msb.2011.39 info:eu-repo/semantics/altIdentifier/doi/10.1038/msb.2011.39 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1038/msb.2011.39 |
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F62 - Physiologie végétale - Croissance et développement U10 - Informatique, mathématiques et statistiques développement biologique auxine Arabidopsis http://aims.fao.org/aos/agrovoc/c_921 http://aims.fao.org/aos/agrovoc/c_726 http://aims.fao.org/aos/agrovoc/c_33291 F62 - Physiologie végétale - Croissance et développement U10 - Informatique, mathématiques et statistiques développement biologique auxine Arabidopsis http://aims.fao.org/aos/agrovoc/c_921 http://aims.fao.org/aos/agrovoc/c_726 http://aims.fao.org/aos/agrovoc/c_33291 |
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F62 - Physiologie végétale - Croissance et développement U10 - Informatique, mathématiques et statistiques développement biologique auxine Arabidopsis http://aims.fao.org/aos/agrovoc/c_921 http://aims.fao.org/aos/agrovoc/c_726 http://aims.fao.org/aos/agrovoc/c_33291 F62 - Physiologie végétale - Croissance et développement U10 - Informatique, mathématiques et statistiques développement biologique auxine Arabidopsis http://aims.fao.org/aos/agrovoc/c_921 http://aims.fao.org/aos/agrovoc/c_726 http://aims.fao.org/aos/agrovoc/c_33291 Vernoux, Teva Brunoud, Géraldine Farcot, Etienne Morin, Valérie Van Den Daele, Hilde Legrand, Jonathan Oliva, Marina Das, Pradeep Larrieu, Antoine Wells, Darren Guédon, Yann Armitage, Lynne Picard, Franck Guyomarc'h, Soizic Cellier, Coralie Parry, Geraint Koumproglou, Rachil Doonan, John H. Estelle, Mark Godin, Christophe Kepinski, Stefan Bennett, Malcolm J. De Veylder, Lieven Traas, Jan The auxin signalling network translates dynamic input into robust patterning at the shoot apex |
description |
The plant hormone auxin is thought to provide positional information for patterning during development. It is still unclear, however, precisely how auxin is distributed across tissues and how the hormone is sensed in space and time. The control of gene expression in response to auxin involves a complex network of over 50 potentially interacting transcriptional activators and repressors, the auxin response factors (ARFs) and Aux/IAAs. Here, we perform a large-scale analysis of the Aux/IAA-ARF pathway in the shoot apex of Arabidopsis, where dynamic auxin-based patterning controls organogenesis. A comprehensive expression map and full interactome uncovered an unexpectedly simple distribution and structure of this pathway in the shoot apex. A mathematical model of the Aux/IAA-ARF network predicted a strong buffering capacity along with spatial differences in auxin sensitivity.We then tested and confirmed these predictions using a novel auxin signalling sensor that reports input into the signalling pathway, in conjunction with the published DR5 transcriptional output reporter. Our results provide evidence that the auxin signalling network is essential to create robust patterns at the shoot apex. |
format |
article |
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F62 - Physiologie végétale - Croissance et développement U10 - Informatique, mathématiques et statistiques développement biologique auxine Arabidopsis http://aims.fao.org/aos/agrovoc/c_921 http://aims.fao.org/aos/agrovoc/c_726 http://aims.fao.org/aos/agrovoc/c_33291 |
author |
Vernoux, Teva Brunoud, Géraldine Farcot, Etienne Morin, Valérie Van Den Daele, Hilde Legrand, Jonathan Oliva, Marina Das, Pradeep Larrieu, Antoine Wells, Darren Guédon, Yann Armitage, Lynne Picard, Franck Guyomarc'h, Soizic Cellier, Coralie Parry, Geraint Koumproglou, Rachil Doonan, John H. Estelle, Mark Godin, Christophe Kepinski, Stefan Bennett, Malcolm J. De Veylder, Lieven Traas, Jan |
author_facet |
Vernoux, Teva Brunoud, Géraldine Farcot, Etienne Morin, Valérie Van Den Daele, Hilde Legrand, Jonathan Oliva, Marina Das, Pradeep Larrieu, Antoine Wells, Darren Guédon, Yann Armitage, Lynne Picard, Franck Guyomarc'h, Soizic Cellier, Coralie Parry, Geraint Koumproglou, Rachil Doonan, John H. Estelle, Mark Godin, Christophe Kepinski, Stefan Bennett, Malcolm J. De Veylder, Lieven Traas, Jan |
author_sort |
Vernoux, Teva |
title |
The auxin signalling network translates dynamic input into robust patterning at the shoot apex |
title_short |
The auxin signalling network translates dynamic input into robust patterning at the shoot apex |
title_full |
The auxin signalling network translates dynamic input into robust patterning at the shoot apex |
title_fullStr |
The auxin signalling network translates dynamic input into robust patterning at the shoot apex |
title_full_unstemmed |
The auxin signalling network translates dynamic input into robust patterning at the shoot apex |
title_sort |
auxin signalling network translates dynamic input into robust patterning at the shoot apex |
url |
http://agritrop.cirad.fr/560833/ http://agritrop.cirad.fr/560833/1/document_560833.pdf |
work_keys_str_mv |
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