Lipases in lipophilization reactions
Lipases are used in various sectors, as pharmaceutical, food or detergency industry. Their advantage versus classical chemical catalysts is that they exhibit a better selectivity and operate in milder reaction conditions. Theses enzymes can also be used in lipophilization reactions corresponding to the grafting of a lipophilic moiety to a hydrophilic one such as sugar, amino acids and proteins, or phenolic compounds. The major difficulty to overcome in such enzyme-catalyzed reaction resides in the fact that the two involved substrates greatly differ in term of polarity and solvent affinity. Therefore, several key parameters are to be considered in order to achieve the reaction in satisfactory kinetics and yields. The present review discusses the nature of such parameters (eg solvent nature, water activity, chemical modification of substrates) and illustrates their effect with examples of lipase-catalyzed lipophilization reactions of various sugar, amino acids or phenolic derivatives. © 2007 Elsevier Inc. All rights reserved.
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Subjects: | Q02 - Traitement et conservation des produits alimentaires, estérase, biocatalyseur, hydrophobicité, ester, estérification, composé phénolique, sucre, synthèse chimique, lipase, http://aims.fao.org/aos/agrovoc/c_2670, http://aims.fao.org/aos/agrovoc/c_27460, http://aims.fao.org/aos/agrovoc/c_33502, http://aims.fao.org/aos/agrovoc/c_2671, http://aims.fao.org/aos/agrovoc/c_28361, http://aims.fao.org/aos/agrovoc/c_5772, http://aims.fao.org/aos/agrovoc/c_7498, http://aims.fao.org/aos/agrovoc/c_28580, http://aims.fao.org/aos/agrovoc/c_12194, |
Online Access: | http://agritrop.cirad.fr/541551/ http://agritrop.cirad.fr/541551/1/document_541551.pdf |
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dig-cirad-fr-5415512024-01-28T15:24:35Z http://agritrop.cirad.fr/541551/ http://agritrop.cirad.fr/541551/ Lipases in lipophilization reactions. Villeneuve Pierre. 2007. Biotechnology Advances, 25 : 515-536.https://doi.org/10.1016/j.biotechadv.2007.06.001 <https://doi.org/10.1016/j.biotechadv.2007.06.001> Lipases in lipophilization reactions Villeneuve, Pierre eng 2007 Biotechnology Advances Q02 - Traitement et conservation des produits alimentaires estérase biocatalyseur hydrophobicité ester estérification composé phénolique sucre synthèse chimique lipase http://aims.fao.org/aos/agrovoc/c_2670 http://aims.fao.org/aos/agrovoc/c_27460 http://aims.fao.org/aos/agrovoc/c_33502 http://aims.fao.org/aos/agrovoc/c_2671 http://aims.fao.org/aos/agrovoc/c_28361 http://aims.fao.org/aos/agrovoc/c_5772 http://aims.fao.org/aos/agrovoc/c_7498 http://aims.fao.org/aos/agrovoc/c_28580 http://aims.fao.org/aos/agrovoc/c_12194 Lipases are used in various sectors, as pharmaceutical, food or detergency industry. Their advantage versus classical chemical catalysts is that they exhibit a better selectivity and operate in milder reaction conditions. Theses enzymes can also be used in lipophilization reactions corresponding to the grafting of a lipophilic moiety to a hydrophilic one such as sugar, amino acids and proteins, or phenolic compounds. The major difficulty to overcome in such enzyme-catalyzed reaction resides in the fact that the two involved substrates greatly differ in term of polarity and solvent affinity. Therefore, several key parameters are to be considered in order to achieve the reaction in satisfactory kinetics and yields. The present review discusses the nature of such parameters (eg solvent nature, water activity, chemical modification of substrates) and illustrates their effect with examples of lipase-catalyzed lipophilization reactions of various sugar, amino acids or phenolic derivatives. © 2007 Elsevier Inc. All rights reserved. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/541551/1/document_541551.pdf application/pdf Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1016/j.biotechadv.2007.06.001 10.1016/j.biotechadv.2007.06.001 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biotechadv.2007.06.001 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1016/j.biotechadv.2007.06.001 |
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Q02 - Traitement et conservation des produits alimentaires estérase biocatalyseur hydrophobicité ester estérification composé phénolique sucre synthèse chimique lipase http://aims.fao.org/aos/agrovoc/c_2670 http://aims.fao.org/aos/agrovoc/c_27460 http://aims.fao.org/aos/agrovoc/c_33502 http://aims.fao.org/aos/agrovoc/c_2671 http://aims.fao.org/aos/agrovoc/c_28361 http://aims.fao.org/aos/agrovoc/c_5772 http://aims.fao.org/aos/agrovoc/c_7498 http://aims.fao.org/aos/agrovoc/c_28580 http://aims.fao.org/aos/agrovoc/c_12194 Q02 - Traitement et conservation des produits alimentaires estérase biocatalyseur hydrophobicité ester estérification composé phénolique sucre synthèse chimique lipase http://aims.fao.org/aos/agrovoc/c_2670 http://aims.fao.org/aos/agrovoc/c_27460 http://aims.fao.org/aos/agrovoc/c_33502 http://aims.fao.org/aos/agrovoc/c_2671 http://aims.fao.org/aos/agrovoc/c_28361 http://aims.fao.org/aos/agrovoc/c_5772 http://aims.fao.org/aos/agrovoc/c_7498 http://aims.fao.org/aos/agrovoc/c_28580 http://aims.fao.org/aos/agrovoc/c_12194 |
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Q02 - Traitement et conservation des produits alimentaires estérase biocatalyseur hydrophobicité ester estérification composé phénolique sucre synthèse chimique lipase http://aims.fao.org/aos/agrovoc/c_2670 http://aims.fao.org/aos/agrovoc/c_27460 http://aims.fao.org/aos/agrovoc/c_33502 http://aims.fao.org/aos/agrovoc/c_2671 http://aims.fao.org/aos/agrovoc/c_28361 http://aims.fao.org/aos/agrovoc/c_5772 http://aims.fao.org/aos/agrovoc/c_7498 http://aims.fao.org/aos/agrovoc/c_28580 http://aims.fao.org/aos/agrovoc/c_12194 Q02 - Traitement et conservation des produits alimentaires estérase biocatalyseur hydrophobicité ester estérification composé phénolique sucre synthèse chimique lipase http://aims.fao.org/aos/agrovoc/c_2670 http://aims.fao.org/aos/agrovoc/c_27460 http://aims.fao.org/aos/agrovoc/c_33502 http://aims.fao.org/aos/agrovoc/c_2671 http://aims.fao.org/aos/agrovoc/c_28361 http://aims.fao.org/aos/agrovoc/c_5772 http://aims.fao.org/aos/agrovoc/c_7498 http://aims.fao.org/aos/agrovoc/c_28580 http://aims.fao.org/aos/agrovoc/c_12194 Villeneuve, Pierre Lipases in lipophilization reactions |
description |
Lipases are used in various sectors, as pharmaceutical, food or detergency industry. Their advantage versus classical chemical catalysts is that they exhibit a better selectivity and operate in milder reaction conditions. Theses enzymes can also be used in lipophilization reactions corresponding to the grafting of a lipophilic moiety to a hydrophilic one such as sugar, amino acids and proteins, or phenolic compounds. The major difficulty to overcome in such enzyme-catalyzed reaction resides in the fact that the two involved substrates greatly differ in term of polarity and solvent affinity. Therefore, several key parameters are to be considered in order to achieve the reaction in satisfactory kinetics and yields. The present review discusses the nature of such parameters (eg solvent nature, water activity, chemical modification of substrates) and illustrates their effect with examples of lipase-catalyzed lipophilization reactions of various sugar, amino acids or phenolic derivatives. © 2007 Elsevier Inc. All rights reserved. |
format |
article |
topic_facet |
Q02 - Traitement et conservation des produits alimentaires estérase biocatalyseur hydrophobicité ester estérification composé phénolique sucre synthèse chimique lipase http://aims.fao.org/aos/agrovoc/c_2670 http://aims.fao.org/aos/agrovoc/c_27460 http://aims.fao.org/aos/agrovoc/c_33502 http://aims.fao.org/aos/agrovoc/c_2671 http://aims.fao.org/aos/agrovoc/c_28361 http://aims.fao.org/aos/agrovoc/c_5772 http://aims.fao.org/aos/agrovoc/c_7498 http://aims.fao.org/aos/agrovoc/c_28580 http://aims.fao.org/aos/agrovoc/c_12194 |
author |
Villeneuve, Pierre |
author_facet |
Villeneuve, Pierre |
author_sort |
Villeneuve, Pierre |
title |
Lipases in lipophilization reactions |
title_short |
Lipases in lipophilization reactions |
title_full |
Lipases in lipophilization reactions |
title_fullStr |
Lipases in lipophilization reactions |
title_full_unstemmed |
Lipases in lipophilization reactions |
title_sort |
lipases in lipophilization reactions |
url |
http://agritrop.cirad.fr/541551/ http://agritrop.cirad.fr/541551/1/document_541551.pdf |
work_keys_str_mv |
AT villeneuvepierre lipasesinlipophilizationreactions |
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