Data on a genome-wide association study of type 2 diabetes in a Maya population
Maya communities have been shown to exhibit type 2 diabetes (T2D) with high prevalence compared with Mexican mestizo populations. Furthermore, some variants associated with the risk for T2D have been described. In this study, we describe the results of a pilot genome wide association study (GWAS) using 817,823 single nucleotide polymorphisms (SNPs) to identify candidate variants for replication in future studies. Herein, we present the GWAS study data, which were divided into three parts: first, 1289 ancestry informative markers (AIMs) were selected for Latino populations containing European, African, and Native American SNPs obtained from the literature; second, a GWAS hypothesis free to select candidate genes associated with T2D was performed, which identified 24 candidate genes; and third, 39 SNPs previously associated with T2D or related traits were replicated. This article is associated with the original article published in “Gene” under the title “Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population”.
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Elsevier
2020
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Subjects: | INDIGENOUS PEOPLES, GENETIC MARKERS, ANCESTRY, DIABETES, |
Online Access: | https://hdl.handle.net/10883/20596 |
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dig-cimmyt-10883-205962022-12-06T20:16:47Z Data on a genome-wide association study of type 2 diabetes in a Maya population Totomoch-Serra, A. Domínguez-Cruz, M.G. Muñoz, M. de L. García-Escalante, M.G. Burgueño, J. Díaz-Badillo, A. Valadez-González, N. Pinto-Escalantes, D. INDIGENOUS PEOPLES GENETIC MARKERS ANCESTRY DIABETES Maya communities have been shown to exhibit type 2 diabetes (T2D) with high prevalence compared with Mexican mestizo populations. Furthermore, some variants associated with the risk for T2D have been described. In this study, we describe the results of a pilot genome wide association study (GWAS) using 817,823 single nucleotide polymorphisms (SNPs) to identify candidate variants for replication in future studies. Herein, we present the GWAS study data, which were divided into three parts: first, 1289 ancestry informative markers (AIMs) were selected for Latino populations containing European, African, and Native American SNPs obtained from the literature; second, a GWAS hypothesis free to select candidate genes associated with T2D was performed, which identified 24 candidate genes; and third, 39 SNPs previously associated with T2D or related traits were replicated. This article is associated with the original article published in “Gene” under the title “Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population”. 2019-12-19T01:10:17Z 2019-12-19T01:10:17Z 2020 Article Published Version 2352-3409 (Print) https://hdl.handle.net/10883/20596 10.1016/j.dib.2019.104866 English Open Access PDF MEXICO Netherlands Elsevier art. 104866 28 Data in Brief |
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INDIGENOUS PEOPLES GENETIC MARKERS ANCESTRY DIABETES INDIGENOUS PEOPLES GENETIC MARKERS ANCESTRY DIABETES |
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INDIGENOUS PEOPLES GENETIC MARKERS ANCESTRY DIABETES INDIGENOUS PEOPLES GENETIC MARKERS ANCESTRY DIABETES Totomoch-Serra, A. Domínguez-Cruz, M.G. Muñoz, M. de L. García-Escalante, M.G. Burgueño, J. Díaz-Badillo, A. Valadez-González, N. Pinto-Escalantes, D. Data on a genome-wide association study of type 2 diabetes in a Maya population |
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Maya communities have been shown to exhibit type 2 diabetes (T2D) with high prevalence compared with Mexican mestizo populations. Furthermore, some variants associated with the risk for T2D have been described. In this study, we describe the results of a pilot genome wide association study (GWAS) using 817,823 single nucleotide polymorphisms (SNPs) to identify candidate variants for replication in future studies. Herein, we present the GWAS study data, which were divided into three parts: first, 1289 ancestry informative markers (AIMs) were selected for Latino populations containing European, African, and Native American SNPs obtained from the literature; second, a GWAS hypothesis free to select candidate genes associated with T2D was performed, which identified 24 candidate genes; and third, 39 SNPs previously associated with T2D or related traits were replicated. This article is associated with the original article published in “Gene” under the title “Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population”. |
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Article |
topic_facet |
INDIGENOUS PEOPLES GENETIC MARKERS ANCESTRY DIABETES |
author |
Totomoch-Serra, A. Domínguez-Cruz, M.G. Muñoz, M. de L. García-Escalante, M.G. Burgueño, J. Díaz-Badillo, A. Valadez-González, N. Pinto-Escalantes, D. |
author_facet |
Totomoch-Serra, A. Domínguez-Cruz, M.G. Muñoz, M. de L. García-Escalante, M.G. Burgueño, J. Díaz-Badillo, A. Valadez-González, N. Pinto-Escalantes, D. |
author_sort |
Totomoch-Serra, A. |
title |
Data on a genome-wide association study of type 2 diabetes in a Maya population |
title_short |
Data on a genome-wide association study of type 2 diabetes in a Maya population |
title_full |
Data on a genome-wide association study of type 2 diabetes in a Maya population |
title_fullStr |
Data on a genome-wide association study of type 2 diabetes in a Maya population |
title_full_unstemmed |
Data on a genome-wide association study of type 2 diabetes in a Maya population |
title_sort |
data on a genome-wide association study of type 2 diabetes in a maya population |
publisher |
Elsevier |
publishDate |
2020 |
url |
https://hdl.handle.net/10883/20596 |
work_keys_str_mv |
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