CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the ring domain that is present across eukaryotes

RING ubiquitin E3 ligases enclose a RING domain for ubiquitin ligase activity and associated domains and/or conserved motifs outside the RING domain that collectively facilitate their classification and usually reveal some of key information related to mechanism of action. Here we describe a new family of E3 ligases that encodes a RING-H2 domain related in sequence to the ATL and BTL RING-H2 domains. This family, named CTL, encodes a motif designed as YEELL that expands 21 amino acids next to the RING-H2 domain that is present across most eukaryotic lineages. E3 ubiquitin ligase BIG BROTHER is a plant CTL that regulates organ size, and SUMO-targeted ubiquitin E3 ligase RNF111/ARKADIA is a vertebrate CTL. Basal animal and vertebrate, as well as fungi species, encode a single CTL gene that constraints the number of paralogs observed in vertebrates. Conversely, as previously described in ATL and BTL families in plants, CTL genes range from a single copy in green algae and 3 to 5 copies in basal species to 9 to 35 copies in angiosperms. Our analysis describes key structural features of a novel family of E3 ubiquitin ligases as an integral component of the set of core eukaryotic genes.

Bibliographic Details

Main Authors:	DOMINGO JIMENEZ LOPEZ, LAURA AGUILAR HENONIN, JUAN MANUEL GONZALEZ PRIETO, Víctor Hugo Aguilar Hernández, PLINIO ANTONIO GUZMAN VILLATE
Format:	info:eu-repo/semantics/article biblioteca
Language:	eng
Subjects:	info:eu-repo/classification/Autores/CTL PROTEIN, info:eu-repo/classification/Autores/PROTEIN, info:eu-repo/classification/Autores/UBIQUITIN PROTEIN LIGASE E3, info:eu-repo/classification/Autores/UNCLASSIFIED DRUG, info:eu-repo/classification/Autores/ZINC FINGER PROTEIN, info:eu-repo/classification/Autores/UBIQUITIN PROTEIN LIGASE, info:eu-repo/classification/cti/2,
Online Access:	http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1528
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