The Leishmanicidal Effect of (3S)-16,17Didehydrofalcarinol, an Oxylipin Isolated from Tridax procumbens, is Independent of NO Production
The in vitro leishmanicidal effect of (3S)-16,17-didehydrofalcarinol (1) isolated from Tridax procumbens whole plant against Leishmania mexicana, the causative agent of cutaneous leishmaniasis (chiclero’s ulcer) in the New World, was investigated. This oxylipin showed signifi cant in vitro activity against promastigotes and intracellular amastigotes of L. mexicana. Its inhibitory effect on amastigotes was not due to activation of NO in recombinant γ-interferon-stimulated macrophages, since the production of NO was decreased in presence of the oxylipin. This is the fi rst report on the leishmanicidal activity against the intracellular stage (amastigote) of the oxylipin (3S)-16,17-didehydrofalcarinol.
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| Format: | info:eu-repo/semantics/article biblioteca |
| Language: | eng |
| Subjects: | info:eu-repo/classification/cti/6, |
| Online Access: | http://cicy.repositorioinstitucional.mx/jspui/handle/1003/136 |
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| Summary: | The in vitro leishmanicidal effect of (3S)-16,17-didehydrofalcarinol (1) isolated from Tridax procumbens whole
plant against Leishmania mexicana, the causative agent of cutaneous leishmaniasis (chiclero’s ulcer) in the
New World, was investigated. This oxylipin showed signifi cant in vitro activity against promastigotes and intracellular
amastigotes of L.
mexicana.
Its inhibitory effect on amastigotes was not due to activation
of NO in
recombinant
γ-interferon-stimulated
macrophages,
since the production of NO was decreased
in presence
of
the oxylipin. This is the fi rst report on the leishmanicidal activity against the intracellular stage (amastigote) of
the oxylipin (3S)-16,17-didehydrofalcarinol. |
|---|