Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders
Polyurethanes are very often used in the cardiovascular field due to their tunable physicochemical properties and acceptable hemocompatibility although they suffer from poor endothelialization. With this in mind, we proposed the synthesis of a family of degradable segmented poly(urea)urethanes (SPUUs) using amino acids (L-arginine, glycine and L-aspartic acid) as chain extenders. These polymers degraded slowly in PBS (pH 7.4) after 24 weeks via a gradual decrease in molecular weight. In contrast, accelerated degradation showed higher mass loss under acidic, alkaline and oxidative media. MTT tests on polyurethanes with L-arginine as chain extenders showed no adverse effect on the metabolism of human umbilical vein endothelial cells (HUVECs) indicating the leachables did not provoke any toxic responses. In addition, SPUUs containing L-arginine promoted higher levels of HUVECs adhesion, spreading and viability after 7 days compared to the commonly used Tecoflex polyurethane. The biodegradability and HUVEC proliferation on L-arginine-based SPUUs suggests that they can be used in the design of vasculargrafts for tissue engineering.
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dig-cicy-1003-1052016-10-24T17:30:19Z Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders JUAN VALERIO CAUICH RODRIGUEZ 2013-04-30 info:eu-repo/semantics/article Polyurethanes are very often used in the cardiovascular field due to their tunable physicochemical properties and acceptable hemocompatibility although they suffer from poor endothelialization. With this in mind, we proposed the synthesis of a family of degradable segmented poly(urea)urethanes (SPUUs) using amino acids (L-arginine, glycine and L-aspartic acid) as chain extenders. These polymers degraded slowly in PBS (pH 7.4) after 24 weeks via a gradual decrease in molecular weight. In contrast, accelerated degradation showed higher mass loss under acidic, alkaline and oxidative media. MTT tests on polyurethanes with L-arginine as chain extenders showed no adverse effect on the metabolism of human umbilical vein endothelial cells (HUVECs) indicating the leachables did not provoke any toxic responses. In addition, SPUUs containing L-arginine promoted higher levels of HUVECs adhesion, spreading and viability after 7 days compared to the commonly used Tecoflex polyurethane. The biodegradability and HUVEC proliferation on L-arginine-based SPUUs suggests that they can be used in the design of vasculargrafts for tissue engineering. info:eu-repo/classification/cti/7 info:eu-repo/classification/cti/7 http://cicy.repositorioinstitucional.mx/jspui/handle/1003/105 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 application/pdf |
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info:eu-repo/classification/cti/7 info:eu-repo/classification/cti/7 info:eu-repo/classification/cti/7 info:eu-repo/classification/cti/7 JUAN VALERIO CAUICH RODRIGUEZ Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders |
description |
Polyurethanes are very often used in the cardiovascular
field due to their tunable physicochemical properties
and acceptable hemocompatibility although they suffer from
poor endothelialization. With this in mind, we proposed the
synthesis of a family of degradable segmented poly(urea)urethanes
(SPUUs) using amino acids (L-arginine, glycine and
L-aspartic acid) as chain extenders. These polymers degraded
slowly in PBS (pH 7.4) after 24 weeks via a gradual decrease in
molecular weight. In contrast, accelerated degradation showed
higher mass loss under acidic, alkaline and oxidative media.
MTT tests on polyurethanes with L-arginine as chain extenders
showed no adverse effect on the metabolism of human umbilical
vein endothelial cells (HUVECs) indicating the leachables did
not provoke any toxic responses. In addition, SPUUs containing
L-arginine promoted higher levels of HUVECs adhesion,
spreading and viability after 7 days compared to the commonly
used Tecoflex polyurethane. The biodegradability and HUVEC
proliferation on L-arginine-based SPUUs suggests that they
can be used in the design of vasculargrafts for tissue engineering. |
format |
info:eu-repo/semantics/article |
topic_facet |
info:eu-repo/classification/cti/7 info:eu-repo/classification/cti/7 |
author |
JUAN VALERIO CAUICH RODRIGUEZ |
author_facet |
JUAN VALERIO CAUICH RODRIGUEZ |
author_sort |
JUAN VALERIO CAUICH RODRIGUEZ |
title |
Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders |
title_short |
Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders |
title_full |
Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders |
title_fullStr |
Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders |
title_full_unstemmed |
Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders |
title_sort |
characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders |
url |
http://cicy.repositorioinstitucional.mx/jspui/handle/1003/105 |
work_keys_str_mv |
AT juanvaleriocauichrodriguez characterizationandbiocompatibilitystudiesofnewdegradablepolyureaurethanespreparedwitharginineglycineorasparticacidaschainextenders |
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1756089190298157056 |