Immunomodulatory effects of heated ovomucoid-depleted egg white in a BALB/c mouse model of egg allergy
El pdf del artículo es la versión pre-print.-- et al.
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American Chemical Society
2011
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| Online Access: | http://hdl.handle.net/10261/51728 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000038 |
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dig-cial-es-10261-517282016-02-17T08:05:41Z Immunomodulatory effects of heated ovomucoid-depleted egg white in a BALB/c mouse model of egg allergy Jiménez Saiz, Rodrigo Ministerio de Educación y Ciencia (España) Ministerio de Ciencia e Innovación (España) Natural Sciences and Engineering Research Council of Canada El pdf del artículo es la versión pre-print.-- et al. Oral immunotherapy (OIT) is a promising therapeutic approach for treating food allergy. The treatment with heated ovomucoid-depleted egg white (HOMEW) in egg-allergic patients is noteworthy; however, OIT protocols are still experimental, and a better knowledge of the underlying mechanism is required. The objective of this work was to investigate the immunomodulatory effects of HOMEW and characterize the underlying mechanism in a BALB/c mouse model of egg allergy. Mice were sensitized with EW and treated with HOMEW. Post treatment, mice were challenged with EW and euthanized for collecting blood and spleen. Markers of allergic clinical outcomes were measured as histamine concentration, serum antibody activity, and cytokine production from cultured splenocytes. Digestibility of HOMEW was assessed mimicking physiological conditions in vitro. The HOMEW demonstrated high digestibility. The treatment induced a marked increase of the Th1/Th2 ratio in the high-dose treatment group. Treated mice had significantly less histamine, EW-specific IgE, and IL-4 and more IFN-γ and IL-10. This study confirms the mechanisms involved in successful tolerance induction with OIT using HOMEW and allows understanding of the vital role of surrogate allergy markers involved in immune modulation. © 2011 American Chemical Society. This work was supported by a discovery grant from NSERC to Y.M. and by Project AGL2008-01740 (Spanish Ministry of Education and Science). R.J.-S. acknowledges the financial support of MICINN through a FPU grant. Peer Reviewed 2012-06-18T09:53:21Z 2012-06-18T09:53:21Z 2011 2012-06-18T09:53:21Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1021/jf202963r issn: 0021-8561 e-issn: 1520-5118 Journal of Agricultural and Food Chemistry 59(24): 13195-13202 (2011) http://hdl.handle.net/10261/51728 10.1021/jf202963r http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000038 en http://dx.doi.org/10.1021/jf202963r open American Chemical Society |
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El pdf del artículo es la versión pre-print.-- et al. |
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Ministerio de Educación y Ciencia (España) |
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Ministerio de Educación y Ciencia (España) Jiménez Saiz, Rodrigo |
| format |
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Jiménez Saiz, Rodrigo |
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Jiménez Saiz, Rodrigo Immunomodulatory effects of heated ovomucoid-depleted egg white in a BALB/c mouse model of egg allergy |
| author_sort |
Jiménez Saiz, Rodrigo |
| title |
Immunomodulatory effects of heated ovomucoid-depleted egg white in a BALB/c mouse model of egg allergy |
| title_short |
Immunomodulatory effects of heated ovomucoid-depleted egg white in a BALB/c mouse model of egg allergy |
| title_full |
Immunomodulatory effects of heated ovomucoid-depleted egg white in a BALB/c mouse model of egg allergy |
| title_fullStr |
Immunomodulatory effects of heated ovomucoid-depleted egg white in a BALB/c mouse model of egg allergy |
| title_full_unstemmed |
Immunomodulatory effects of heated ovomucoid-depleted egg white in a BALB/c mouse model of egg allergy |
| title_sort |
immunomodulatory effects of heated ovomucoid-depleted egg white in a balb/c mouse model of egg allergy |
| publisher |
American Chemical Society |
| publishDate |
2011 |
| url |
http://hdl.handle.net/10261/51728 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000038 |
| work_keys_str_mv |
AT jimenezsaizrodrigo immunomodulatoryeffectsofheatedovomucoiddepletedeggwhiteinabalbcmousemodelofeggallergy |
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1777671107546972160 |