Highly isoxanthohumol enriched hop extract obtained by pressurized hot water extraction (PHWE): Chemical and functional characterization
Hop (Humulus lupulus) is one of the richest natural sources of a prenylfalvonoids such as xanthohumol (XN), desmetylxanthohumol (DMX), isoxanthohumol (IX) or 8-prenylnaringenin (8-PN), being XN the most abundant of them in the raw material. So far, obtention of prenylflavonoids have been done by chemical synthesis or extraction with organic solvents, with no described methods for the isolation of IX, which has been reported to have anti-inflammatory properties. In this study, pressurized hot water extraction (PHWE) it is shown not only as effective method to extract some prenylflavonoids but to selectively change the relative amount of them, favoring the extraction of IX against XN. Thus, pressurized water extraction at 150 °C showed a high selectivity towards IX, being proposed as a method to enrich natural hop´s extracts in IX. On the other hand, the extracts thus obtained were chemically characterized and evaluated for their anti-inflammatory activity, which was higher than the expected by its content in IX.
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Elsevier
2012-04-30
|
| Subjects: | Prenylflavonoids, Xanthohumol (XN), Isoxanthohumol (IX), Pressurized Hot Water Extraction (PHWE), Subcritical Water Extraction (SWE), |
| Online Access: | http://hdl.handle.net/10261/49959 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100007273 http://dx.doi.org/10.13039/100012818 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Hop (Humulus lupulus) is one of the richest natural sources of a prenylfalvonoids such as xanthohumol (XN), desmetylxanthohumol (DMX), isoxanthohumol (IX) or 8-prenylnaringenin (8-PN), being XN the most abundant of them in the raw material. So far, obtention of prenylflavonoids have been done by chemical synthesis or extraction with organic solvents, with no described methods for the isolation of IX, which has been reported to have anti-inflammatory properties. In this study, pressurized hot water extraction (PHWE) it is shown not only as effective method to extract some prenylflavonoids but to selectively change the relative amount of them, favoring the extraction of IX against XN. Thus, pressurized water extraction at 150 °C showed a high selectivity towards IX, being proposed as a method to enrich natural hop´s extracts in IX. On the other hand, the extracts thus obtained were chemically characterized and evaluated for their anti-inflammatory activity, which was higher than the expected by its content in IX. |
|---|