In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential

In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential

Resumen del trabajo presentado a la 8th International Conference of Food Digestion (ICFD), celebrada en Porto (Portugal) del 9 al 11 de abril de 2024.

Saved in:
Bibliographic Details
Main Authors: Machado, Fernanda, Coimbra, Manuel A., Castillo, M. Dolores del, Coreta-Gomes, Filipe
Other Authors: Fundação para a Ciência e a Tecnologia (Portugal)
Format: póster de congreso biblioteca
Language:English
Published: 2024
Online Access:http://hdl.handle.net/10261/364518
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-cial-es-10261-364518
record_format koha
spelling dig-cial-es-10261-3645182024-07-26T12:23:05Z In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential Machado, Fernanda Coimbra, Manuel A. Castillo, M. Dolores del Coreta-Gomes, Filipe Fundação para a Ciência e a Tecnologia (Portugal) European Commission Ministério da Ciência, Tecnologia e Ensino Superior (Portugal) Resumen del trabajo presentado a la 8th International Conference of Food Digestion (ICFD), celebrada en Porto (Portugal) del 9 al 11 de abril de 2024. Coffee brew is well prevalent in human diet and several benelits lor health have been described (Machado et al. 2023). These bioactive properties have been related with the chemical diversity which compases the coffee beverage, although structure-function relationships are still overlooked. One ol the compounds most present in coffee brew are the soluble libres, composed by arabinogalactans and galactomannans polysaccharides, and melanoidins, which may impact on cholesterol metabolism (Silva et al. 2021). Using a simplified in vitre intestinal model, the effect ol chemically characterized coffee and polysaccharides rich fractions on cholesterel bioaccessibility was accessed. Coffee as well as the arabinogalactans and galactomannans polysaccharides rich fractions were shown to decrease cholesterol solubility, due to their capacity to sequestrate bile salt.(Coreta-Gomes et al. 2020) Moreover, coffee brew also was tested to evaluate their effect on the bioavailability ola cholesterel analogue through Caco-2 cellline model, mimetizing intestinal epithelium. The results show that in the presence ol coffee extracts, a decrease ol the sterol permeability coefficient to hall was observed, which was attributed to an increased sterol precipitation and its deposition on the apical epithelial surface.(Pires et al. 2022). Coffee soluble libres, namely arabinogalactans and melanoidins rich lractions were also evaluated regarding the outcome of their fermentability using an in vitre colonic fermentation model. Both fractions decreased the acetate: prepionate ratio, which is indicative ola potential HMG-CoA reductase inhibition. Furthermore, melanoidin rich fraction also show to decrease the conversion of primary to secondary bile salts. As secondary bile salts are more prone to emulsify cholesterol, their decrease will have impact on cholesterel bioaccessibility and bioavailability, leading to a lower cholesterel absorption. This work prevides evidence that digestion ol coffee and their high molecular weight extracts, namely polysaccharides and melanoidins, have cardioprotective potential, opening avenues to develop functional load ingredients based on coffee which can a id on the comba! ol cardiovascular diseases, which are one ol the deadliest illnesses worldwide. FCT/MCTES, LAQV-REQUIMTE (UIDB/50006/2020) research unit which include Coreta-Gomes contract and the project PTDC/QUI-OUT/29373/2017 (OE. FEDER. POCI, PT2020); Machado acknowledges FCT PhD fellowship (2020.06768.80); UCNMR facility (FEDER. European Regional Development Fund, COMPETE Program) and FCT grants (RECI/QEQQFI/0168/2012, CENTR0-07-CT62-FEDER-002012); RNRMN and CCC (UID/QUI/00313!2019). Peer reviewed 2024-07-26T12:23:04Z 2024-07-26T12:23:04Z 2024 póster de congreso 8th International Conference on Food Digestion (2024) http://hdl.handle.net/10261/364518 en Sí none
institution CIAL ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-cial-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del CIAL España
language English
description Resumen del trabajo presentado a la 8th International Conference of Food Digestion (ICFD), celebrada en Porto (Portugal) del 9 al 11 de abril de 2024.
author2 Fundação para a Ciência e a Tecnologia (Portugal)
author_facet Fundação para a Ciência e a Tecnologia (Portugal)
Machado, Fernanda
Coimbra, Manuel A.
Castillo, M. Dolores del
Coreta-Gomes, Filipe
format póster de congreso
author Machado, Fernanda
Coimbra, Manuel A.
Castillo, M. Dolores del
Coreta-Gomes, Filipe
spellingShingle Machado, Fernanda
Coimbra, Manuel A.
Castillo, M. Dolores del
Coreta-Gomes, Filipe
In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential
author_sort Machado, Fernanda
title In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential
title_short In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential
title_full In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential
title_fullStr In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential
title_full_unstemmed In vitro digestion of coffe brew and their fractions: Their relevance towards cardioprotective potential
title_sort in vitro digestion of coffe brew and their fractions: their relevance towards cardioprotective potential
publishDate 2024
url http://hdl.handle.net/10261/364518
work_keys_str_mv AT machadofernanda invitrodigestionofcoffebrewandtheirfractionstheirrelevancetowardscardioprotectivepotential
AT coimbramanuela invitrodigestionofcoffebrewandtheirfractionstheirrelevancetowardscardioprotectivepotential
AT castillomdoloresdel invitrodigestionofcoffebrewandtheirfractionstheirrelevancetowardscardioprotectivepotential
AT coretagomesfilipe invitrodigestionofcoffebrewandtheirfractionstheirrelevancetowardscardioprotectivepotential
_version_ 1807154124077137920

Similar Items