Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery

Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery

This article belongs to the Special Issue Polyphenols in Plant-Based Foods: Effects of Food Processing on Their Content, Bioaccessibility, Bioavailability, and Bioactivity.

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Bibliographic Details
Main Authors: Siles-Sánchez, María de las Nieves, Jaime, Laura, Villalva, Marisol, Santoyo, Susana
Other Authors: Ministerio de Ciencia, Innovación y Universidades (España)
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2022
Subjects:Origanum majorana, Spray drying, Phenolic compounds, Ionic gelation, Nano/microparticles, Colon delivery systems,
Online Access:http://hdl.handle.net/10261/297247
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spelling dig-cial-es-10261-2972472023-03-10T12:50:03Z Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery Siles-Sánchez, María de las Nieves Jaime, Laura Villalva, Marisol Santoyo, Susana Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Comunidad de Madrid Origanum majorana Spray drying Phenolic compounds Ionic gelation Nano/microparticles Colon delivery systems This article belongs to the Special Issue Polyphenols in Plant-Based Foods: Effects of Food Processing on Their Content, Bioaccessibility, Bioavailability, and Bioactivity. In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray drying of microparticles (0.75% low molecular weight chitosan dissolved in 0.4% of acetic acid) presented the best encapsulation efficiency (near 75%), with size ranges from 1.55 to 1.68 µm that allowed the encapsulation of 1.25–1.88 mg/mL of extract. Release studies of individual marjoram phenolic compounds at pH 2 and 7.4 showed that most of the compounds remained encapsulated in the microparticles. Only arbutin and vicenin II presented a high initial burst release. As the polarity of the compounds was reduced, their initial release decreased. In addition, after gastrointestinal digestion, most of marjoram phenolic compounds remained encapsulated. These results prove that chitosan microparticlescould protect the marjoram phenolic compounds during gastrointestinal digestion, specifically those related to anticancer activity, which enables their application as colon-specific delivery systems. This research was funded by the Spanish Government (Project: PID2019-110183RB-C22/AEI/10.13039/501100011033) and by Comunidad Autónoma de Madrid (ALIBIRD2020-CM, S2018/BAA-4343). Peer reviewed 2023-03-10T12:50:02Z 2023-03-10T12:50:02Z 2022 artículo Foods 11(22): 3657 (2022) http://hdl.handle.net/10261/297247 10.3390/foods11223657 2304-8158 36429249 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110183RB-C22/ES/DESARROLLO DE FORMULAS ALIMENTARIAS DE PRECISION DIRIGIDAS AL TRATAMIENTO DEL CANCER DE COLON: PRODUCCION Y CARACTERIZACION/ S2018/BAA-4343/ALIBIRD2020-CM Foods Publisher's version https://doi.org/10.3390/foods11223657 Sí open application/pdf Multidisciplinary Digital Publishing Institute
institution CIAL ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-cial-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del CIAL España
language English
topic Origanum majorana
Spray drying
Phenolic compounds
Ionic gelation
Nano/microparticles
Colon delivery systems
Origanum majorana
Spray drying
Phenolic compounds
Ionic gelation
Nano/microparticles
Colon delivery systems
spellingShingle Origanum majorana
Spray drying
Phenolic compounds
Ionic gelation
Nano/microparticles
Colon delivery systems
Origanum majorana
Spray drying
Phenolic compounds
Ionic gelation
Nano/microparticles
Colon delivery systems
Siles-Sánchez, María de las Nieves
Jaime, Laura
Villalva, Marisol
Santoyo, Susana
Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery
description This article belongs to the Special Issue Polyphenols in Plant-Based Foods: Effects of Food Processing on Their Content, Bioaccessibility, Bioavailability, and Bioactivity.
author2 Ministerio de Ciencia, Innovación y Universidades (España)
author_facet Ministerio de Ciencia, Innovación y Universidades (España)
Siles-Sánchez, María de las Nieves
Jaime, Laura
Villalva, Marisol
Santoyo, Susana
format artículo
topic_facet Origanum majorana
Spray drying
Phenolic compounds
Ionic gelation
Nano/microparticles
Colon delivery systems
author Siles-Sánchez, María de las Nieves
Jaime, Laura
Villalva, Marisol
Santoyo, Susana
author_sort Siles-Sánchez, María de las Nieves
title Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery
title_short Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery
title_full Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery
title_fullStr Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery
title_full_unstemmed Encapsulation of Marjoram phenolic compounds using chitosan to improve its colon delivery
title_sort encapsulation of marjoram phenolic compounds using chitosan to improve its colon delivery
publisher Multidisciplinary Digital Publishing Institute
publishDate 2022
url http://hdl.handle.net/10261/297247
work_keys_str_mv AT silessanchezmariadelasnieves encapsulationofmarjoramphenoliccompoundsusingchitosantoimproveitscolondelivery
AT jaimelaura encapsulationofmarjoramphenoliccompoundsusingchitosantoimproveitscolondelivery
AT villalvamarisol encapsulationofmarjoramphenoliccompoundsusingchitosantoimproveitscolondelivery
AT santoyosusana encapsulationofmarjoramphenoliccompoundsusingchitosantoimproveitscolondelivery
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