Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism

The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public health emergency. Increasing understanding about predisposing factors to infection and severity is now a priority. Genetic, metabolic, and environmental factors can play a crucial role in the course and clinical outcome of COVID-19. We aimed to investigate the putative relationship between genetic factors associated to obesity, metabolism and lifestyle, and the presence and severity of SARS-CoV-2 infection. A total of 249 volunteers (178 women and 71 men, with mean and ± SD age of 49 ± 11 years) characterized for dietary, lifestyle habits and anthropometry, were studied for presence and severity of COVID-19 infection, and genotyped for 26 genetic variants related to obesity, lipid profile, inflammation, and biorhythm patterns. A statistically significant association was found concerning a protective effect of APOE rs7412 against SARS-CoV-2 infection (p = 0.039; OR 0.216; CI 0.084, 0.557) after correction for multiple comparisons. This protective effect was also ascribed to the APOɛ2 allele (p = 0.001; OR 0.207; CI 0.0796, 0.538). The genetic variant rs7412 resulting in ApoE2, genetic determinant of lipid and lipoprotein levels, could play a significant role protecting against SARS-CoV-2 infection.

Bibliographic Details

Main Authors:	Espinosa-Salinas, Isabel, Colmenarejo, Gonzalo, Fernández-Díaz, Cristina M., Gómez de Cedrón, Marta, Martínez, J. Alfredo, Reglero, Guillermo, Ramírez de Molina, Ana
Other Authors:	Comunidad de Madrid
Format:	artículo biblioteca
Language:	English
Published:	Nature Publishing Group 2022-05-04
Online Access:	http://hdl.handle.net/10261/269869 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100000780
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