Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities

Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities

This article belongs to the Special Issue Secondary Metabolites Extraction and/or Functionalization: from Industrial Co-product to Cosmetic Applications.

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Main Authors: Gómez-López, Iván, Lobo-Rodrigo, Gloria, Portillo, María P., Cano, M. Pilar
Other Authors: Ministerio de Ciencia e Innovación (España)
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2021
Subjects:Opuntia stricta var. Dillenii whole fruits, Anti-inflammatory activity, Ultrasound-assisted extraction, Antioxidant activity, Green solvents, Phenolic compounds,
Online Access:http://hdl.handle.net/10261/263473
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100004837
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spelling dig-cial-es-10261-2634732022-03-10T03:30:14Z Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities Gómez-López, Iván Lobo-Rodrigo, Gloria Portillo, María P. Cano, M. Pilar Ministerio de Ciencia e Innovación (España) CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Opuntia stricta var. Dillenii whole fruits Anti-inflammatory activity Ultrasound-assisted extraction Antioxidant activity Green solvents Phenolic compounds This article belongs to the Special Issue Secondary Metabolites Extraction and/or Functionalization: from Industrial Co-product to Cosmetic Applications. Opuntia stricta var. Dillenii’s prickly pears are an underutilized fruit with a high content of betalains and phenolic compounds that could bring potential health benefits for humans. The aim of this study is the optimization of the “green” extraction of betalains and phenolic compounds from Opuntia stricta var. Dillenii’s whole fruits by ultrasound-assisted extraction (UAE), using a response surface methodology (RSM) by a central composite design (CCD) in order to obtain extracts rich in betalains and phenolic compounds with proven biological activities. For UAE optimization, the extraction temperature (20–50 °C), the amplitude (20–50%) and the ethanol volume in extraction solvent (15–80%, v/v) were selected as independent variables. All combinations were conducted at 2, 5, 10, 20 and 30 min to determinate the time effect. The betalain and phenolic compound content in Opuntia stricta var. Dillenii’s whole fruits and UAE extracts were identified by HPLC-DAD-ESI/MS and HPLC-DAD-MS/QTOF and the antioxidant (ORAC method) and the anti-inflammatory (hyaluronidase inhibition method) in vitro biological activities also were determined. The most efficient extraction time was 5 min and the best UAE parameter combination was 50% amplitude, 15% ethanol in solvent (ethanol/water, 15/85, v/v) and 20 °C temperature, obtaining 10.06 ± 0.10 mg of total major betalains/g dry weight, 2.32 ± 0.08 mg of piscidic acid/g dry weight and 0.38 ± 0.00 mg of total major flavonoids/g dry weight. All applied UAE combinations significantly improved the in vitro bioactive activities (antioxidant and anti-inflammatory) of the Opuntia stricta var. Dillenii’s extracts compared to the bioactivities of the extracts obtained by standard homogenization processes. This research was funded by the Spanish Ministry of Science and Innovation, project number RTA2015-00044-C02-02 and number PID2020-118300RB-C21. Peer reviewed 2022-03-09T11:30:03Z 2022-03-09T11:30:03Z 2021 artículo http://purl.org/coar/resource_type/c_6501 Antioxidants 10(11): 1786 (2021) http://hdl.handle.net/10261/263473 10.3390/antiox10111786 2076-3921 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004837 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118300RB-C21/ES/PROCESOS INNOVADORES GREEN PARA EL DESARROLLO DE NUEVAS FORMULACIONES INTELIGENTES A PARTIR DE LOS SUBPRODUCTOS DE FRUTOS DE OPUNTIA SPP., PARA LA PREVENCION DE LA ESTEANOSI/ Publisher's version https://doi.org/10.3390/antiox10111786 Sí open Multidisciplinary Digital Publishing Institute
institution CIAL ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-cial-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del CIAL España
language English
topic Opuntia stricta var. Dillenii whole fruits
Anti-inflammatory activity
Ultrasound-assisted extraction
Antioxidant activity
Green solvents
Phenolic compounds
Opuntia stricta var. Dillenii whole fruits
Anti-inflammatory activity
Ultrasound-assisted extraction
Antioxidant activity
Green solvents
Phenolic compounds
spellingShingle Opuntia stricta var. Dillenii whole fruits
Anti-inflammatory activity
Ultrasound-assisted extraction
Antioxidant activity
Green solvents
Phenolic compounds
Opuntia stricta var. Dillenii whole fruits
Anti-inflammatory activity
Ultrasound-assisted extraction
Antioxidant activity
Green solvents
Phenolic compounds
Gómez-López, Iván
Lobo-Rodrigo, Gloria
Portillo, María P.
Cano, M. Pilar
Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities
description This article belongs to the Special Issue Secondary Metabolites Extraction and/or Functionalization: from Industrial Co-product to Cosmetic Applications.
author2 Ministerio de Ciencia e Innovación (España)
author_facet Ministerio de Ciencia e Innovación (España)
Gómez-López, Iván
Lobo-Rodrigo, Gloria
Portillo, María P.
Cano, M. Pilar
format artículo
topic_facet Opuntia stricta var. Dillenii whole fruits
Anti-inflammatory activity
Ultrasound-assisted extraction
Antioxidant activity
Green solvents
Phenolic compounds
author Gómez-López, Iván
Lobo-Rodrigo, Gloria
Portillo, María P.
Cano, M. Pilar
author_sort Gómez-López, Iván
title Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities
title_short Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities
title_full Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities
title_fullStr Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities
title_full_unstemmed Ultrasound-assisted “green” extraction (UAE) of antioxidant compounds (betalains and phenolics) from Opuntia stricta var. Dilenii’s fruits: optimization and biological activities
title_sort ultrasound-assisted “green” extraction (uae) of antioxidant compounds (betalains and phenolics) from opuntia stricta var. dilenii’s fruits: optimization and biological activities
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://hdl.handle.net/10261/263473
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100004837
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