Metabolome-based clustering after moderate wine consumption
Grouping individuals according to their metabolic capacities (metabotyping) has caused a shift from individualised to grouped treatments for the optimisation of nutritional interventions. Several studies have reported a stratification of patients into metabolic clusters after the intake of certain foods, of which polyphenols seem to be mostly associated with metabotypes. Despite this, there is a lack of metabotyping studies regarding wine consumption. In this context, the human urinary metabolome of healthy volunteers (n=41) was explored by means of a non-targeted metabolomic approach after an intervention with red wine (250 mL/day, 28 days). Three clusters of volunteers based on their relative production of phenolic metabolites were perceived , and the compounds responsible for this clustering were identified. To our knowledge, this is the first time that different urinary metabotypes have been described in healthy volunteers after moderate red wine consumption. Our findings suggest that stratification of individuals in clinical trials according to their metabotype is necessary to fully understand the health effects of wine polyphenols.
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Format: | artículo biblioteca |
Language: | English |
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International Viticulture and Enology Society
2020
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Subjects: | Polyphenols, Wine, Urinary metabolome, Metabotypes clustering, |
Online Access: | http://hdl.handle.net/10261/228682 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 |
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dig-cial-es-10261-2286822021-02-06T04:42:05Z Metabolome-based clustering after moderate wine consumption Esteban-Fernández, Adelaida Ibáñez, Clara Simó, Carolina Bartolomé, Begoña Moreno-Arribas, M. Victoria Ministerio de Economía y Competitividad (España) Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) Comunidad de Madrid Polyphenols Wine Urinary metabolome Metabotypes clustering Grouping individuals according to their metabolic capacities (metabotyping) has caused a shift from individualised to grouped treatments for the optimisation of nutritional interventions. Several studies have reported a stratification of patients into metabolic clusters after the intake of certain foods, of which polyphenols seem to be mostly associated with metabotypes. Despite this, there is a lack of metabotyping studies regarding wine consumption. In this context, the human urinary metabolome of healthy volunteers (n=41) was explored by means of a non-targeted metabolomic approach after an intervention with red wine (250 mL/day, 28 days). Three clusters of volunteers based on their relative production of phenolic metabolites were perceived , and the compounds responsible for this clustering were identified. To our knowledge, this is the first time that different urinary metabotypes have been described in healthy volunteers after moderate red wine consumption. Our findings suggest that stratification of individuals in clinical trials according to their metabotype is necessary to fully understand the health effects of wine polyphenols. This work was funded by the Spanish MINECO (AGL2015-64522-C2-R and AGL2017-89055-R projects) and Comunidad de Madrid (ALIBIRD2020-CM P2018/BAA-4343). A.E-F is a recipient of a fellowship from the FPIMINECO programme. Peer reviewed 2021-02-05T10:00:23Z 2021-02-05T10:00:23Z 2020 artículo http://purl.org/coar/resource_type/c_6501 OENO One 54(3): 455-467 (2020) 2494-1271 http://hdl.handle.net/10261/228682 10.20870/oeno-one.2020.54.3.2983 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-64522-C2-R P2018/BAA-4343/ALIBIRD-CM info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-89055-R AGL2017-89055-R/AEI/10.13039/501100011033 Publisher's version https://doi.org/10.20870/oeno-one.2020.54.3.2983 Sí open International Viticulture and Enology Society |
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Polyphenols Wine Urinary metabolome Metabotypes clustering Polyphenols Wine Urinary metabolome Metabotypes clustering |
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Polyphenols Wine Urinary metabolome Metabotypes clustering Polyphenols Wine Urinary metabolome Metabotypes clustering Esteban-Fernández, Adelaida Ibáñez, Clara Simó, Carolina Bartolomé, Begoña Moreno-Arribas, M. Victoria Metabolome-based clustering after moderate wine consumption |
description |
Grouping individuals according to their metabolic capacities (metabotyping) has caused a shift from individualised to grouped treatments for the optimisation of nutritional interventions. Several studies have reported a stratification of patients into metabolic clusters after the intake of certain foods, of which polyphenols seem to be mostly associated with metabotypes. Despite this, there is a lack of metabotyping studies regarding wine consumption. In this context, the human urinary metabolome of healthy volunteers (n=41) was explored by means of a non-targeted metabolomic approach after an intervention with red wine (250 mL/day, 28 days). Three clusters of volunteers based on their relative production of phenolic metabolites were perceived , and the compounds responsible for this clustering were identified. To our knowledge, this is the first time that different urinary metabotypes have been described in healthy volunteers after moderate red wine consumption. Our findings suggest that stratification of individuals in clinical trials according to their metabotype is necessary to fully understand the health effects of wine polyphenols. |
author2 |
Ministerio de Economía y Competitividad (España) |
author_facet |
Ministerio de Economía y Competitividad (España) Esteban-Fernández, Adelaida Ibáñez, Clara Simó, Carolina Bartolomé, Begoña Moreno-Arribas, M. Victoria |
format |
artículo |
topic_facet |
Polyphenols Wine Urinary metabolome Metabotypes clustering |
author |
Esteban-Fernández, Adelaida Ibáñez, Clara Simó, Carolina Bartolomé, Begoña Moreno-Arribas, M. Victoria |
author_sort |
Esteban-Fernández, Adelaida |
title |
Metabolome-based clustering after moderate wine consumption |
title_short |
Metabolome-based clustering after moderate wine consumption |
title_full |
Metabolome-based clustering after moderate wine consumption |
title_fullStr |
Metabolome-based clustering after moderate wine consumption |
title_full_unstemmed |
Metabolome-based clustering after moderate wine consumption |
title_sort |
metabolome-based clustering after moderate wine consumption |
publisher |
International Viticulture and Enology Society |
publishDate |
2020 |
url |
http://hdl.handle.net/10261/228682 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 |
work_keys_str_mv |
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1777671466064543744 |