Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation
The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity. MC and decaffeinated mate (DM) were obtained using supercritical CO2 extraction and mainly composed of caffeine and caffeoylquinic acids, respectively. MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid. Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression.
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2020
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Subjects: | Caffeine, Yerba mate, Fat accumulation, Lipogenesis, Ilex paraguariensis, Obesity, |
Online Access: | http://hdl.handle.net/10261/220009 http://dx.doi.org/10.13039/100010443 http://dx.doi.org/10.13039/501100011033 |
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dig-cial-es-10261-2200092020-09-23T01:08:55Z Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation Zapata, Fatima J. Rebollo-Hernanz, Miguel Novakofski, Jan E. Nakamura, Manabu T. González de Mejía, Elvira University of Illinois Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) Caffeine Yerba mate Fat accumulation Lipogenesis Ilex paraguariensis Obesity The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity. MC and decaffeinated mate (DM) were obtained using supercritical CO2 extraction and mainly composed of caffeine and caffeoylquinic acids, respectively. MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid. Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression. The Division of Nutritional Sciences, University of Illinois fully funded this research through the 20/20 initiative. M. Rebollo-Hernanz received funding from the program of the Ministry of Science, Innovation, and Universities for his predoctoral fellowship (FPU15/04238) and the support for the international research at the University of Illinois, Urbana–Champaign (EST18/0064). Peer reviewed 2020-09-22T09:09:20Z 2020-09-22T09:09:20Z 2020 artículo http://purl.org/coar/resource_type/c_6501 Journal of Functional Foods 64: 103646 (2020) 1756-4646 http://hdl.handle.net/10261/220009 10.1016/j.jff.2019.103646 http://dx.doi.org/10.13039/100010443 http://dx.doi.org/10.13039/501100011033 en Publisher's version https://doi.org/10.1016/j.jff.2019.103646 Sí open Elsevier |
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Caffeine Yerba mate Fat accumulation Lipogenesis Ilex paraguariensis Obesity Caffeine Yerba mate Fat accumulation Lipogenesis Ilex paraguariensis Obesity |
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Caffeine Yerba mate Fat accumulation Lipogenesis Ilex paraguariensis Obesity Caffeine Yerba mate Fat accumulation Lipogenesis Ilex paraguariensis Obesity Zapata, Fatima J. Rebollo-Hernanz, Miguel Novakofski, Jan E. Nakamura, Manabu T. González de Mejía, Elvira Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation |
description |
The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity. MC and decaffeinated mate (DM) were obtained using supercritical CO2 extraction and mainly composed of caffeine and caffeoylquinic acids, respectively. MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid. Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression. |
author2 |
University of Illinois |
author_facet |
University of Illinois Zapata, Fatima J. Rebollo-Hernanz, Miguel Novakofski, Jan E. Nakamura, Manabu T. González de Mejía, Elvira |
format |
artículo |
topic_facet |
Caffeine Yerba mate Fat accumulation Lipogenesis Ilex paraguariensis Obesity |
author |
Zapata, Fatima J. Rebollo-Hernanz, Miguel Novakofski, Jan E. Nakamura, Manabu T. González de Mejía, Elvira |
author_sort |
Zapata, Fatima J. |
title |
Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation |
title_short |
Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation |
title_full |
Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation |
title_fullStr |
Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation |
title_full_unstemmed |
Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation |
title_sort |
caffeine, but not other phytochemicals, in mate tea (ilex paraguariensis st. hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation |
publisher |
Elsevier |
publishDate |
2020 |
url |
http://hdl.handle.net/10261/220009 http://dx.doi.org/10.13039/100010443 http://dx.doi.org/10.13039/501100011033 |
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