Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?
This article belongs to the Special Issue Role of Nutraceuticals in Metabolic and Gastrointestinal Disorders.
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Multidisciplinary Digital Publishing Institute
2020-04-26
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| Online Access: | http://hdl.handle.net/10261/211409 http://dx.doi.org/10.13039/501100003339 |
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dig-cial-es-10261-2114092021-12-28T16:39:30Z Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals? Martínez, Vicente Iriondo-DeHond, Amaia Borrelli, Francesca Capasso, Raffaele Castillo, M. Dolores del Abalo, Raquel Consejo Superior de Investigaciones Científicas (España) This article belongs to the Special Issue Role of Nutraceuticals in Metabolic and Gastrointestinal Disorders. Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used for different purposes, like the production of fibers, the production of oil from the seeds, and especially for recreational or medical purposes. Phytocannabinoids (terpenophenolic compounds derived from the plant), include the well-known psychoactive cannabinoid Δ9 -tetrahydrocannabinol, and many non-psychoactive cannabinoids, like cannabidiol. The endocannabinoid system (ECS) comprises of endocannabinoid ligands, enzymes for synthesis and degradation of such ligands, and receptors. This system is widely distributed in the gastrointestinal tract, where phytocannabinoids exert potent effects, particularly under pathological (i.e., inflammatory) conditions. Herein, we will first look at the hemp plant as a possible source of new functional food ingredients and nutraceuticals that might be eventually useful to treat or even prevent gastrointestinal conditions. Subsequently, we will briefly describe the ECS and the general pharmacology of phytocannabinoids. Finally, we will revise the available data showing that non-psychoactive phytocannabinoids, particularly cannabidiol, may be useful to treat different disorders and diseases of the gastrointestinal tract. With the increasing interest in the development of functional foods for a healthy life, the non-psychoactive phytocannabinoids are hoped to find a place as nutraceuticals and food ingredients also for a healthy gastrointestinal tract function. This research was funded by CSIC, 201970E117. 2020-05-14T13:55:31Z 2020-05-14T13:55:31Z 2020-04-26 2020-05-14T13:55:31Z artículo http://purl.org/coar/resource_type/c_6501 International Journal of Molecular Sciences 21(9): 3067 (2020) http://hdl.handle.net/10261/211409 10.3390/ijms21093067 1422-0067 http://dx.doi.org/10.13039/501100003339 32357565 Publisher's version https://doi.org/10.3390/ijms21093067 open Multidisciplinary Digital Publishing Institute |
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This article belongs to the Special Issue Role of Nutraceuticals in Metabolic and Gastrointestinal Disorders. |
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Consejo Superior de Investigaciones Científicas (España) |
| author_facet |
Consejo Superior de Investigaciones Científicas (España) Martínez, Vicente Iriondo-DeHond, Amaia Borrelli, Francesca Capasso, Raffaele Castillo, M. Dolores del Abalo, Raquel |
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artículo |
| author |
Martínez, Vicente Iriondo-DeHond, Amaia Borrelli, Francesca Capasso, Raffaele Castillo, M. Dolores del Abalo, Raquel |
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Martínez, Vicente Iriondo-DeHond, Amaia Borrelli, Francesca Capasso, Raffaele Castillo, M. Dolores del Abalo, Raquel Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals? |
| author_sort |
Martínez, Vicente |
| title |
Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals? |
| title_short |
Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals? |
| title_full |
Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals? |
| title_fullStr |
Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals? |
| title_full_unstemmed |
Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals? |
| title_sort |
cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals? |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2020-04-26 |
| url |
http://hdl.handle.net/10261/211409 http://dx.doi.org/10.13039/501100003339 |
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