A review of bioactive factors in human breastmilk: A focus on prematurity
Preterm birth is an increasing worldwide problem. Prematurity is the second most common cause of death in children under 5 years of age. It is associated with a higher risk of several pathologies in the perinatal period and adulthood. Maternal milk, a complex fluid with several bioactive factors, is the best option for the newborn. Its dynamic composition is influenced by diverse factors such as maternal age, lactation period, and health status. The aim of the present review is to summarize the current knowledge regarding some bioactive factors present in breastmilk, namely antioxidants, growth factors, adipokines, and cytokines, paying specific attention to prematurity. The revised literature reveals that the highest levels of these bioactive factors are found in the colostrum and they decrease along the lactation period; bioactive factors are found in higher levels in preterm as compared to full-term milk, they are lacking in formula milk, and decreased in donated milk. However, there are still some gaps and inconclusive data, and further research in this field is needed. Given the fact that many preterm mothers are unable to complete breastfeeding, new information could be important to develop infant supplements that best match preterm human milk.
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Format: | artículo biblioteca |
Language: | English |
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Multidisciplinary Digital Publishing Institute
2019
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Subjects: | Adipokines, Antioxidants, Breastfeeding, Cytokines, Growth factors, |
Online Access: | http://hdl.handle.net/10261/193006 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 |
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dig-cial-es-10261-1930062021-02-04T13:41:09Z A review of bioactive factors in human breastmilk: A focus on prematurity Gila-Diaz, Andrea Arribas, Silvia M. Algara, Alba Martín-Cabrejas, María A. López de Pablo, Ángel L. Saenz de Pipaón, Miguel Ramiro-Cortijo, David Agencia Estatal de Investigación (España) Ministerio de Economía y Competitividad (España) Ministerio de Ciencia, Innovación y Universidades (España) European Commission Ramiro-Cortijo, David [0000-0001-7442-1586] Adipokines Antioxidants Breastfeeding Cytokines Growth factors Preterm birth is an increasing worldwide problem. Prematurity is the second most common cause of death in children under 5 years of age. It is associated with a higher risk of several pathologies in the perinatal period and adulthood. Maternal milk, a complex fluid with several bioactive factors, is the best option for the newborn. Its dynamic composition is influenced by diverse factors such as maternal age, lactation period, and health status. The aim of the present review is to summarize the current knowledge regarding some bioactive factors present in breastmilk, namely antioxidants, growth factors, adipokines, and cytokines, paying specific attention to prematurity. The revised literature reveals that the highest levels of these bioactive factors are found in the colostrum and they decrease along the lactation period; bioactive factors are found in higher levels in preterm as compared to full-term milk, they are lacking in formula milk, and decreased in donated milk. However, there are still some gaps and inconclusive data, and further research in this field is needed. Given the fact that many preterm mothers are unable to complete breastfeeding, new information could be important to develop infant supplements that best match preterm human milk. This work was supported by Ministerio de Economia y Competitividad (grant number FEM2015-63631-R) to SMA and the Ministerio de Ciencia, Innovación y Universidades (Spain) (grant number RTI2018-097504-B-100) to SMA and MAM-C. Both grants were co-financed with FEDER funds. Peer reviewed 2019-10-21T12:02:52Z 2019-10-21T12:02:52Z 2019 artículo http://purl.org/coar/resource_type/c_6501 Nutrients 11(6): 1307 (2019) http://hdl.handle.net/10261/193006 10.3390/nu11061307 2072-6643 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 31185620 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FEM2015-63631-R RTI2018-097504-B-100/AEI/10.13039/501100011033 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097504-B-100 Publisher's version https://doi.org/10.3390/nu11061307 Sí open Multidisciplinary Digital Publishing Institute |
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Adipokines Antioxidants Breastfeeding Cytokines Growth factors Adipokines Antioxidants Breastfeeding Cytokines Growth factors |
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Adipokines Antioxidants Breastfeeding Cytokines Growth factors Adipokines Antioxidants Breastfeeding Cytokines Growth factors Gila-Diaz, Andrea Arribas, Silvia M. Algara, Alba Martín-Cabrejas, María A. López de Pablo, Ángel L. Saenz de Pipaón, Miguel Ramiro-Cortijo, David A review of bioactive factors in human breastmilk: A focus on prematurity |
description |
Preterm birth is an increasing worldwide problem. Prematurity is the second most common cause of death in children under 5 years of age. It is associated with a higher risk of several pathologies in the perinatal period and adulthood. Maternal milk, a complex fluid with several bioactive factors, is the best option for the newborn. Its dynamic composition is influenced by diverse factors such as maternal age, lactation period, and health status. The aim of the present review is to summarize the current knowledge regarding some bioactive factors present in breastmilk, namely antioxidants, growth factors, adipokines, and cytokines, paying specific attention to prematurity. The revised literature reveals that the highest levels of these bioactive factors are found in the colostrum and they decrease along the lactation period; bioactive factors are found in higher levels in preterm as compared to full-term milk, they are lacking in formula milk, and decreased in donated milk. However, there are still some gaps and inconclusive data, and further research in this field is needed. Given the fact that many preterm mothers are unable to complete breastfeeding, new information could be important to develop infant supplements that best match preterm human milk. |
author2 |
Agencia Estatal de Investigación (España) |
author_facet |
Agencia Estatal de Investigación (España) Gila-Diaz, Andrea Arribas, Silvia M. Algara, Alba Martín-Cabrejas, María A. López de Pablo, Ángel L. Saenz de Pipaón, Miguel Ramiro-Cortijo, David |
format |
artículo |
topic_facet |
Adipokines Antioxidants Breastfeeding Cytokines Growth factors |
author |
Gila-Diaz, Andrea Arribas, Silvia M. Algara, Alba Martín-Cabrejas, María A. López de Pablo, Ángel L. Saenz de Pipaón, Miguel Ramiro-Cortijo, David |
author_sort |
Gila-Diaz, Andrea |
title |
A review of bioactive factors in human breastmilk: A focus on prematurity |
title_short |
A review of bioactive factors in human breastmilk: A focus on prematurity |
title_full |
A review of bioactive factors in human breastmilk: A focus on prematurity |
title_fullStr |
A review of bioactive factors in human breastmilk: A focus on prematurity |
title_full_unstemmed |
A review of bioactive factors in human breastmilk: A focus on prematurity |
title_sort |
review of bioactive factors in human breastmilk: a focus on prematurity |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2019 |
url |
http://hdl.handle.net/10261/193006 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 |
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