Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
[Background] Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression.
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Format: | artículo biblioteca |
Language: | English |
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BioMed Central
2018
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Subjects: | Pancreatic cancer, Asteraceae, Lamiaceae, Chemotherapeutic agents, 5-Fluororacil, |
Online Access: | http://hdl.handle.net/10261/192550 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329 |
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dig-cial-es-10261-1925502019-10-15T00:55:34Z Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts Mouhid, Lamia Gómez de Cedrón, Marta Vargas, Teodoro García-Carrascosa, Elena Herranz, Nieves García-Risco, Mónica R. Reglero, Guillermo Fornari, Tiziana Ramírez de Molina, Ana Ministerio de Economía y Competitividad (España) Comunidad de Madrid European Commission Pancreatic cancer Asteraceae Lamiaceae Chemotherapeutic agents 5-Fluororacil [Background] Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression. [Methods] In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO2 Extraction –SFE- and Ultrasonic Assisted Extraction –UAE-) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches. [Results] Asteraceae extracts showed better results as antitumoral agents than Lamiaceae by inducing cytotoxicity and inhibiting cell transformation, and SFE extracts were most efficient than UAE extracts. In addition, SFE derived plant extracts from Achillea millefolium and Calendula officinalis displayed synergism with the chemotherapeutic 5-Fluororacil. [Conclusion] These results show how Yarrow and Marigold SFE-derived extracts can inhibit pancreatic cancer cell growth, and could be proposed for a comprehensive study to determine the molecular mechanisms involved in their bioactivity with the final aim to propose them as potential adjuvants in pancreatic cancer therapy. This work has been supported by Ministerio de Economía y Competitividad del Gobierno de España (MINECO, Plan Nacional I + D + i) AGL2016–76736-C3/FEDER, and Gobierno Regional de la Comunidad de Madrid (P2013/ABI2728, ALIBIRD-CM). Peer reviewed 2019-10-14T07:38:47Z 2019-10-14T07:38:47Z 2018 artículo http://purl.org/coar/resource_type/c_6501 BMC Complementary and Alternative Medicine 18(1): 254 (2018) http://hdl.handle.net/10261/192550 10.1186/s12906-018-2322-6 1472-6882 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329 30223811 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016–76736-C3 P2013/ABI2728/ALIBIRD-CM Publisher's version https://doi.org/10.1186/s12906-018-2322-6 Sí open BioMed Central Springer Nature |
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Pancreatic cancer Asteraceae Lamiaceae Chemotherapeutic agents 5-Fluororacil Pancreatic cancer Asteraceae Lamiaceae Chemotherapeutic agents 5-Fluororacil |
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Pancreatic cancer Asteraceae Lamiaceae Chemotherapeutic agents 5-Fluororacil Pancreatic cancer Asteraceae Lamiaceae Chemotherapeutic agents 5-Fluororacil Mouhid, Lamia Gómez de Cedrón, Marta Vargas, Teodoro García-Carrascosa, Elena Herranz, Nieves García-Risco, Mónica R. Reglero, Guillermo Fornari, Tiziana Ramírez de Molina, Ana Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts |
description |
[Background] Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression. |
author2 |
Ministerio de Economía y Competitividad (España) |
author_facet |
Ministerio de Economía y Competitividad (España) Mouhid, Lamia Gómez de Cedrón, Marta Vargas, Teodoro García-Carrascosa, Elena Herranz, Nieves García-Risco, Mónica R. Reglero, Guillermo Fornari, Tiziana Ramírez de Molina, Ana |
format |
artículo |
topic_facet |
Pancreatic cancer Asteraceae Lamiaceae Chemotherapeutic agents 5-Fluororacil |
author |
Mouhid, Lamia Gómez de Cedrón, Marta Vargas, Teodoro García-Carrascosa, Elena Herranz, Nieves García-Risco, Mónica R. Reglero, Guillermo Fornari, Tiziana Ramírez de Molina, Ana |
author_sort |
Mouhid, Lamia |
title |
Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts |
title_short |
Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts |
title_full |
Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts |
title_fullStr |
Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts |
title_full_unstemmed |
Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts |
title_sort |
identification of antitumoral agents against human pancreatic cancer cells from asteraceae and lamiaceae plant extracts |
publisher |
BioMed Central |
publishDate |
2018 |
url |
http://hdl.handle.net/10261/192550 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329 |
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