Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts

Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts

[Background] Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression.

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Main Authors: Mouhid, Lamia, Gómez de Cedrón, Marta, Vargas, Teodoro, García-Carrascosa, Elena, Herranz, Nieves, García-Risco, Mónica R., Reglero, Guillermo, Fornari, Tiziana, Ramírez de Molina, Ana
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Language:English
Published: BioMed Central 2018
Subjects:Pancreatic cancer, Asteraceae, Lamiaceae, Chemotherapeutic agents, 5-Fluororacil,
Online Access:http://hdl.handle.net/10261/192550
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/100012818
http://dx.doi.org/10.13039/501100003329
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spelling dig-cial-es-10261-1925502019-10-15T00:55:34Z Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts Mouhid, Lamia Gómez de Cedrón, Marta Vargas, Teodoro García-Carrascosa, Elena Herranz, Nieves García-Risco, Mónica R. Reglero, Guillermo Fornari, Tiziana Ramírez de Molina, Ana Ministerio de Economía y Competitividad (España) Comunidad de Madrid European Commission Pancreatic cancer Asteraceae Lamiaceae Chemotherapeutic agents 5-Fluororacil [Background] Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression. [Methods] In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO2 Extraction –SFE- and Ultrasonic Assisted Extraction –UAE-) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches. [Results] Asteraceae extracts showed better results as antitumoral agents than Lamiaceae by inducing cytotoxicity and inhibiting cell transformation, and SFE extracts were most efficient than UAE extracts. In addition, SFE derived plant extracts from Achillea millefolium and Calendula officinalis displayed synergism with the chemotherapeutic 5-Fluororacil. [Conclusion] These results show how Yarrow and Marigold SFE-derived extracts can inhibit pancreatic cancer cell growth, and could be proposed for a comprehensive study to determine the molecular mechanisms involved in their bioactivity with the final aim to propose them as potential adjuvants in pancreatic cancer therapy. This work has been supported by Ministerio de Economía y Competitividad del Gobierno de España (MINECO, Plan Nacional I + D + i) AGL2016–76736-C3/FEDER, and Gobierno Regional de la Comunidad de Madrid (P2013/ABI2728, ALIBIRD-CM). Peer reviewed 2019-10-14T07:38:47Z 2019-10-14T07:38:47Z 2018 artículo http://purl.org/coar/resource_type/c_6501 BMC Complementary and Alternative Medicine 18(1): 254 (2018) http://hdl.handle.net/10261/192550 10.1186/s12906-018-2322-6 1472-6882 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100003329 30223811 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016–76736-C3 P2013/ABI2728/ALIBIRD-CM Publisher's version https://doi.org/10.1186/s12906-018-2322-6 Sí open BioMed Central Springer Nature
institution CIAL ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-cial-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del CIAL España
language English
topic Pancreatic cancer
Asteraceae
Lamiaceae
Chemotherapeutic agents
5-Fluororacil
Pancreatic cancer
Asteraceae
Lamiaceae
Chemotherapeutic agents
5-Fluororacil
spellingShingle Pancreatic cancer
Asteraceae
Lamiaceae
Chemotherapeutic agents
5-Fluororacil
Pancreatic cancer
Asteraceae
Lamiaceae
Chemotherapeutic agents
5-Fluororacil
Mouhid, Lamia
Gómez de Cedrón, Marta
Vargas, Teodoro
García-Carrascosa, Elena
Herranz, Nieves
García-Risco, Mónica R.
Reglero, Guillermo
Fornari, Tiziana
Ramírez de Molina, Ana
Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
description [Background] Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression.
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Mouhid, Lamia
Gómez de Cedrón, Marta
Vargas, Teodoro
García-Carrascosa, Elena
Herranz, Nieves
García-Risco, Mónica R.
Reglero, Guillermo
Fornari, Tiziana
Ramírez de Molina, Ana
format artículo
topic_facet Pancreatic cancer
Asteraceae
Lamiaceae
Chemotherapeutic agents
5-Fluororacil
author Mouhid, Lamia
Gómez de Cedrón, Marta
Vargas, Teodoro
García-Carrascosa, Elena
Herranz, Nieves
García-Risco, Mónica R.
Reglero, Guillermo
Fornari, Tiziana
Ramírez de Molina, Ana
author_sort Mouhid, Lamia
title Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
title_short Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
title_full Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
title_fullStr Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
title_full_unstemmed Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
title_sort identification of antitumoral agents against human pancreatic cancer cells from asteraceae and lamiaceae plant extracts
publisher BioMed Central
publishDate 2018
url http://hdl.handle.net/10261/192550
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/100012818
http://dx.doi.org/10.13039/501100003329
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