Monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats
Resumen del trabajo presentado al 2nd Workshop of the European Network for Gastrointestinal Health Research (ENGIHR): Diet and the gut microbiota: New directions; celebrado en Helsinki (Finlandia) del 2 al 4 de mayo de 2012.
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dig-cial-es-10261-1551122020-09-25T09:15:42Z Monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats Marín-Manzano, M. Carmen Hernández-Hernández, Oswaldo Abecia, Leticia Rubio, Luis A. Moreno, F. Javier Sanz, M. Luz Clemente, Alfonso Resumen del trabajo presentado al 2nd Workshop of the European Network for Gastrointestinal Health Research (ENGIHR): Diet and the gut microbiota: New directions; celebrado en Helsinki (Finlandia) del 2 al 4 de mayo de 2012. A study was performed to compare the in vivo ileal digestibility and bifidogenic effect in intestinal microbiota of novel galactooligosaccharides (GOS) derived from lactulose (GOS-Lu) or commercially available derived from lactase (GOS-La) in growing rats. Animals were fed either a control diet or diets containing 1%(w/w) of GOS-Lu or GOS-La for 14 d. Quantitative analysis of carbohydrates from dietary and ileal samples demonstrated that the trisaccharide fraction of GOS-Lu was significantly more resistan! to gut digestion than that from GOS-La, according to their ileal digestibility rates (12.5 and 52.9%, respectively), whilst the disaccharide fraction of GOS-Lu was fully resista nito the extreme environment of the upper digestive tract. The low ileal digestibility of GOS-Lu was attributed to the great resistance of galactosyl-fructoses to mammalian digestive enzymes, highlighting the key role played by the monomer type and linkage involved in the oligosaccharide chain. The partial digestion of GOS-La trisaccharides showed that glycosidic linkages (1>6) and (1>2) between galactose and glucose monomers were significantly more resistant to gastrointestinal digestion than the linkage (1>4) between galactose units. The absence of GOS-La and GOS-Lu digestion-resistant oligosaccharides in fecal samples indicated that they were readily fermented within the large irttestine, enabling both GOS lo have a potential prebiotic function. GOS-Lu exerted a significant bifidogenic effect in intestinal samples after 14 d of treatment, derived from significan! changes in the pattern and abundance of sorne bifidobacteria species. These novel data support a direct relationship between patterns of resistance lo digestion and bifidogenic properties of galacto-oligosaccharides. Peer Reviewed 2017-09-14T10:11:29Z 2017-09-14T10:11:29Z 2012 2017-09-14T10:11:30Z comunicación de congreso http://purl.org/coar/resource_type/c_5794 2nd Workshop ENGIHR (2012) http://hdl.handle.net/10261/155112 Sí none |
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Resumen del trabajo presentado al 2nd Workshop of the European Network for Gastrointestinal Health Research (ENGIHR): Diet and the gut microbiota: New directions; celebrado en Helsinki (Finlandia) del 2 al 4 de mayo de 2012. |
| format |
comunicación de congreso |
| author |
Marín-Manzano, M. Carmen Hernández-Hernández, Oswaldo Abecia, Leticia Rubio, Luis A. Moreno, F. Javier Sanz, M. Luz Clemente, Alfonso |
| spellingShingle |
Marín-Manzano, M. Carmen Hernández-Hernández, Oswaldo Abecia, Leticia Rubio, Luis A. Moreno, F. Javier Sanz, M. Luz Clemente, Alfonso Monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats |
| author_facet |
Marín-Manzano, M. Carmen Hernández-Hernández, Oswaldo Abecia, Leticia Rubio, Luis A. Moreno, F. Javier Sanz, M. Luz Clemente, Alfonso |
| author_sort |
Marín-Manzano, M. Carmen |
| title |
Monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats |
| title_short |
Monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats |
| title_full |
Monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats |
| title_fullStr |
Monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats |
| title_full_unstemmed |
Monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats |
| title_sort |
monomer and linkage type of galacto-oligosachardies affects their resistance to ileal digestion and bifidogenic effect in rats |
| publishDate |
2012 |
| url |
http://hdl.handle.net/10261/155112 |
| work_keys_str_mv |
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