Effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers
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BioMed Central
2015
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| Online Access: | http://hdl.handle.net/10261/149874 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 |
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dig-cial-es-10261-1498742021-12-27T16:45:17Z Effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers Grases, Félix Sánchez, Ana M. Prodanov, M. Govern de les Illes Balears Instituto de Salud Carlos III European Commission Ministerio de Ciencia e Innovación (España) et al. [Background]: Diverse enzymatic and non-enzymatic antioxidants provide protection against reactive oxygen species in humans and other organisms. The nonenzymatic antioxidants include low molecular mass molecules such as plant-derived phenols. [Aim of study]: This study identified the major phenolic compounds of a grape seed extract by HPLC and analyzed the effect of consumption of biscuits enriched with this extract on the urinary oxidative status of healthy subjects by measurement of urine redox potential. [Methods]: The major phenolic compounds were characterized in a red grape seed extract separated by HPLC with detection by a photodiode array (PDA), fluorescence (FL) and quadrupole mass spectrometer (MS). A nutritional study in a healthy volunteers group was done. Each volunteer ate eight traditional biscuits with no red grape seed extract supplementation. The second day each volunteer ate eight traditional biscuits supplemented with 0.6 % (wt/wt) of grape seed extract. An overnight urine sample was obtained for each treatment. The redox potential was measured at 25 °C using a potentiometer in each urine sample. [Results]: Epicatechin, catechin, procyanidin dimers B1 to B4, and the procyanidin trimer C2 were the major phenolic components in the extract. Epicatechin gallate and procyanidin dimers B1-3-G and B2-3′-G were the major galloylated flavan-3-ols. The forty-six healthy volunteers each shown a reduction of the urine redox potential after the treatment by traditional biscuits supplemented with the grape seed extract. [Conclusions]: This simple dietary intervention significantly reduced (33 %) the urine redox potential, reflecting an overall increase in antioxidant status. Incorporation of plant-derived phenols in the diet may increase anti-oxidative status. This work was supported by grant CTQ2010-18271 from the Ministerio de Ciencia e Innovación (Gobierno de España), by FEDER funds (European Union), and by grant 9/2011 from the Conselleria d’Educació, Cultura i Universitat (Govern de les Illes Balears). CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Spain, also provided support. Peer Reviewed 2017-05-17T11:49:35Z 2017-05-17T11:49:35Z 2015 2017-05-17T11:49:36Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1186/s12937-015-0083-3 e-issn: 1475-2891 Nutrition Journal 14: 94 (2015) http://hdl.handle.net/10261/149874 10.1186/s12937-015-0083-3 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 26353756 Publisher's version https://dx.doi.org/10.1186/s12937-015-0083-3 Sí open BioMed Central |
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et al. |
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Govern de les Illes Balears |
| author_facet |
Govern de les Illes Balears Grases, Félix Sánchez, Ana M. Prodanov, M. |
| format |
artículo |
| author |
Grases, Félix Sánchez, Ana M. Prodanov, M. |
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Grases, Félix Sánchez, Ana M. Prodanov, M. Effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers |
| author_sort |
Grases, Félix |
| title |
Effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers |
| title_short |
Effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers |
| title_full |
Effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers |
| title_fullStr |
Effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers |
| title_full_unstemmed |
Effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers |
| title_sort |
effect of consuming a grape seed supplement with abundant phenolic compounds on the oxidative status of healthy human volunteers |
| publisher |
BioMed Central |
| publishDate |
2015 |
| url |
http://hdl.handle.net/10261/149874 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 |
| work_keys_str_mv |
AT grasesfelix effectofconsumingagrapeseedsupplementwithabundantphenoliccompoundsontheoxidativestatusofhealthyhumanvolunteers AT sanchezanam effectofconsumingagrapeseedsupplementwithabundantphenoliccompoundsontheoxidativestatusofhealthyhumanvolunteers AT prodanovm effectofconsumingagrapeseedsupplementwithabundantphenoliccompoundsontheoxidativestatusofhealthyhumanvolunteers |
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1777671245688471552 |