Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility
Production of prebiotic carbohydrates at competitive prices is a challenge nowadays since the well-established production processes involve many purification steps which are labour intensive and require important amounts of reagents and products thus increasing prebiotic's price. Several processes have been studied in our laboratory involving the use of Supercritical Fluid Technology to fractionate and purify carbohydrate solid mixtures. Research carried out at laboratory scale using theoretical mixtures (lactose/lactulose and galactose/tagatose), commercially available carbohydrate mixtures and carbohydrate mixtures produced by enzymatic transglycosylation and isomerized with complexating reagents demonstrated that purification of prebiotic carbohydrates was technically possible by supercritical fluid extraction. In the present work, the process optimized at laboratory scale to fractionate carbohydrate mixtures produced by enzymatic transglycosylation has been scaled-up to an industrial level and its economic feasibility has been simulated employing AspenONE ® V7.3 software to obtain consistent data supporting the interest of a potential investment for prebiotics production at large scale using supercritical fluids. © 2012 Elsevier B.V.
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Elsevier
2012
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Subjects: | Scale-up, Supercritical fractionation, Carbohydrates, Prebiotic, Economical study, |
Online Access: | http://hdl.handle.net/10261/101366 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011100 http://dx.doi.org/10.13039/100012818 |
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dig-cial-es-10261-1013662018-09-20T07:12:34Z Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility Montañés, Fernando Fornari, Tiziana Olano, Agustín Ibáñez, Elena Ministerio de Economía y Competitividad (España) Comunidad de Madrid Fundación Española para la Ciencia y la Tecnología Fundación Española para la Ciencia y la Tecnología Scale-up Supercritical fractionation Carbohydrates Prebiotic Economical study Production of prebiotic carbohydrates at competitive prices is a challenge nowadays since the well-established production processes involve many purification steps which are labour intensive and require important amounts of reagents and products thus increasing prebiotic's price. Several processes have been studied in our laboratory involving the use of Supercritical Fluid Technology to fractionate and purify carbohydrate solid mixtures. Research carried out at laboratory scale using theoretical mixtures (lactose/lactulose and galactose/tagatose), commercially available carbohydrate mixtures and carbohydrate mixtures produced by enzymatic transglycosylation and isomerized with complexating reagents demonstrated that purification of prebiotic carbohydrates was technically possible by supercritical fluid extraction. In the present work, the process optimized at laboratory scale to fractionate carbohydrate mixtures produced by enzymatic transglycosylation has been scaled-up to an industrial level and its economic feasibility has been simulated employing AspenONE ® V7.3 software to obtain consistent data supporting the interest of a potential investment for prebiotics production at large scale using supercritical fluids. © 2012 Elsevier B.V. This work has been financed by CSD2007-00063 FUN-CFOOD (Programa CONSOLIDER-INGENIO 2010) and Project ALIBIRD S2009/AGR-1469 (Community of Madrid) projects. F.M. thanks MEC and FECyT for a postdoctoral fellowship. Peer Reviewed 2014-08-28T11:53:47Z 2014-08-28T11:53:47Z 2012 2014-08-28T11:53:48Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.chroma.2012.04.039 issn: 0021-9673 e-issn: 1873-3778 Journal of Chromatography A 1250: 92-98 (2012) http://hdl.handle.net/10261/101366 10.1016/j.chroma.2012.04.039 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011100 http://dx.doi.org/10.13039/100012818 #PLACEHOLDER_PARENT_METADATA_VALUE# S2009/AGR-1469/ALIBIRD none Elsevier |
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Scale-up Supercritical fractionation Carbohydrates Prebiotic Economical study Scale-up Supercritical fractionation Carbohydrates Prebiotic Economical study |
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Scale-up Supercritical fractionation Carbohydrates Prebiotic Economical study Scale-up Supercritical fractionation Carbohydrates Prebiotic Economical study Montañés, Fernando Fornari, Tiziana Olano, Agustín Ibáñez, Elena Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility |
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Production of prebiotic carbohydrates at competitive prices is a challenge nowadays since the well-established production processes involve many purification steps which are labour intensive and require important amounts of reagents and products thus increasing prebiotic's price. Several processes have been studied in our laboratory involving the use of Supercritical Fluid Technology to fractionate and purify carbohydrate solid mixtures. Research carried out at laboratory scale using theoretical mixtures (lactose/lactulose and galactose/tagatose), commercially available carbohydrate mixtures and carbohydrate mixtures produced by enzymatic transglycosylation and isomerized with complexating reagents demonstrated that purification of prebiotic carbohydrates was technically possible by supercritical fluid extraction. In the present work, the process optimized at laboratory scale to fractionate carbohydrate mixtures produced by enzymatic transglycosylation has been scaled-up to an industrial level and its economic feasibility has been simulated employing AspenONE ® V7.3 software to obtain consistent data supporting the interest of a potential investment for prebiotics production at large scale using supercritical fluids. © 2012 Elsevier B.V. |
author2 |
Ministerio de Economía y Competitividad (España) |
author_facet |
Ministerio de Economía y Competitividad (España) Montañés, Fernando Fornari, Tiziana Olano, Agustín Ibáñez, Elena |
format |
artículo |
topic_facet |
Scale-up Supercritical fractionation Carbohydrates Prebiotic Economical study |
author |
Montañés, Fernando Fornari, Tiziana Olano, Agustín Ibáñez, Elena |
author_sort |
Montañés, Fernando |
title |
Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility |
title_short |
Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility |
title_full |
Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility |
title_fullStr |
Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility |
title_full_unstemmed |
Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility |
title_sort |
isolation of prebiotic carbohydrates by supercritical fluid extraction. scaling-up and economical feasibility |
publisher |
Elsevier |
publishDate |
2012 |
url |
http://hdl.handle.net/10261/101366 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011100 http://dx.doi.org/10.13039/100012818 |
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