Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells
Breast cancer is the leading cause of cancer-related mortality among females worldwide, and therefore the development of new therapeutic approaches is still needed. Rosemary (Rosmarinus officinalis L.) extract possesses antitumor properties against tumor cells from several organs, including breast. However, in order to apply it as a complementary therapeutic agent in breast cancer, more information is needed regarding the sensitivity of the different breast tumor subtypes and its effect in combination with the currently used chemotherapy. Here, we analyzed the antitumor activities of a supercritical fluid rosemary extract (SFRE) in different breast cancer cells, and used a genomic approach to explore its effect on the modulation of ER-α and HER2 signaling pathways, the most important mitogen pathways related to breast cancer progression. We found that SFRE exerts antitumor activity against breast cancer cells from different tumor subtypes and the downregulation of ER-α and HER2 receptors by SFRE might be involved in its antitumor effect against estrogen-dependent (ER+) and HER2 overexpressing (HER2+) breast cancer subtypes. Moreover, SFRE significantly enhanced the effect of breast cancer chemotherapy (tamoxifen, trastuzumab, and paclitaxel). Overall, our results support the potential utility of SFRE as a complementary approach in breast cancer therapy. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Wiley-VCH
2014
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Subjects: | Estrogen receptor alpha, Human epidermal growth factor receptor-2, Paclitaxel, Rosemary, Breast cancer, |
Online Access: | http://hdl.handle.net/10261/100154 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 |
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dig-cial-es-10261-1001542019-10-14T07:28:03Z Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells González-Vallinas, Margarita Molina, Susana Vicente, G. Sánchez-Martínez, Ruth Vargas, Teodoro García-Risco, Mónica R. Fornari, Tiziana Reglero, Guillermo Ramírez de Molina, Ana Ministerio de Ciencia e Innovación (España) European Commission Estrogen receptor alpha Human epidermal growth factor receptor-2 Paclitaxel Rosemary Breast cancer Breast cancer is the leading cause of cancer-related mortality among females worldwide, and therefore the development of new therapeutic approaches is still needed. Rosemary (Rosmarinus officinalis L.) extract possesses antitumor properties against tumor cells from several organs, including breast. However, in order to apply it as a complementary therapeutic agent in breast cancer, more information is needed regarding the sensitivity of the different breast tumor subtypes and its effect in combination with the currently used chemotherapy. Here, we analyzed the antitumor activities of a supercritical fluid rosemary extract (SFRE) in different breast cancer cells, and used a genomic approach to explore its effect on the modulation of ER-α and HER2 signaling pathways, the most important mitogen pathways related to breast cancer progression. We found that SFRE exerts antitumor activity against breast cancer cells from different tumor subtypes and the downregulation of ER-α and HER2 receptors by SFRE might be involved in its antitumor effect against estrogen-dependent (ER+) and HER2 overexpressing (HER2+) breast cancer subtypes. Moreover, SFRE significantly enhanced the effect of breast cancer chemotherapy (tamoxifen, trastuzumab, and paclitaxel). Overall, our results support the potential utility of SFRE as a complementary approach in breast cancer therapy. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Funded by: Spanish Ministry of Science and Innovation. Grant Numbers: I+D+i AGL2010-21565, 2008-03734, IPT-2011-1248-060000 and European Union Structural Funds. Peer Reviewed 2014-07-18T10:34:14Z 2014-07-18T10:34:14Z 2014 2014-07-18T10:34:14Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1002/elps.201400011 e-issn: 1522-2683 issn: 0173-0835 Electrophoresis 35(11): 1719-1727 (2014) http://hdl.handle.net/10261/100154 10.1002/elps.201400011 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 Sí none Wiley-VCH |
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Estrogen receptor alpha Human epidermal growth factor receptor-2 Paclitaxel Rosemary Breast cancer Estrogen receptor alpha Human epidermal growth factor receptor-2 Paclitaxel Rosemary Breast cancer |
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Estrogen receptor alpha Human epidermal growth factor receptor-2 Paclitaxel Rosemary Breast cancer Estrogen receptor alpha Human epidermal growth factor receptor-2 Paclitaxel Rosemary Breast cancer González-Vallinas, Margarita Molina, Susana Vicente, G. Sánchez-Martínez, Ruth Vargas, Teodoro García-Risco, Mónica R. Fornari, Tiziana Reglero, Guillermo Ramírez de Molina, Ana Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells |
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Breast cancer is the leading cause of cancer-related mortality among females worldwide, and therefore the development of new therapeutic approaches is still needed. Rosemary (Rosmarinus officinalis L.) extract possesses antitumor properties against tumor cells from several organs, including breast. However, in order to apply it as a complementary therapeutic agent in breast cancer, more information is needed regarding the sensitivity of the different breast tumor subtypes and its effect in combination with the currently used chemotherapy. Here, we analyzed the antitumor activities of a supercritical fluid rosemary extract (SFRE) in different breast cancer cells, and used a genomic approach to explore its effect on the modulation of ER-α and HER2 signaling pathways, the most important mitogen pathways related to breast cancer progression. We found that SFRE exerts antitumor activity against breast cancer cells from different tumor subtypes and the downregulation of ER-α and HER2 receptors by SFRE might be involved in its antitumor effect against estrogen-dependent (ER+) and HER2 overexpressing (HER2+) breast cancer subtypes. Moreover, SFRE significantly enhanced the effect of breast cancer chemotherapy (tamoxifen, trastuzumab, and paclitaxel). Overall, our results support the potential utility of SFRE as a complementary approach in breast cancer therapy. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
author2 |
Ministerio de Ciencia e Innovación (España) |
author_facet |
Ministerio de Ciencia e Innovación (España) González-Vallinas, Margarita Molina, Susana Vicente, G. Sánchez-Martínez, Ruth Vargas, Teodoro García-Risco, Mónica R. Fornari, Tiziana Reglero, Guillermo Ramírez de Molina, Ana |
format |
artículo |
topic_facet |
Estrogen receptor alpha Human epidermal growth factor receptor-2 Paclitaxel Rosemary Breast cancer |
author |
González-Vallinas, Margarita Molina, Susana Vicente, G. Sánchez-Martínez, Ruth Vargas, Teodoro García-Risco, Mónica R. Fornari, Tiziana Reglero, Guillermo Ramírez de Molina, Ana |
author_sort |
González-Vallinas, Margarita |
title |
Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells |
title_short |
Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells |
title_full |
Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells |
title_fullStr |
Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells |
title_full_unstemmed |
Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells |
title_sort |
modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells |
publisher |
Wiley-VCH |
publishDate |
2014 |
url |
http://hdl.handle.net/10261/100154 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 |
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