The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance
It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exposed epitopes of the variable surface glycoprotein in Trypanosoma congolense-infected N'Dama (trypanotolerant) and Boran (susceptible) cattle. Similar titres and isotypes were found in both N'Damas and Borans indicating that trypanotolerance is not associated with superior antibody-mediated destruction of trypanosomes. However, significant differences in antibody responses to cryptic VSG epitopes and non-trypanosome antigens were identified. Trypanosusceptible Boran cattle had low IgG1 responses to cryptic epitopes but high IgM responses to non-trypanosome antigens such as 3-galactosidase. In contrast the N'Dama cattle had significantly higher IgG1 responses to cryptic VSG epitopes and negligible responses to 3-galactosidase. These results indicate differences in the induction of anti-trypanosome immune responses between trypanotolerant and susceptible cattle infected with T. congolense.
Main Authors: | , , , , |
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Format: | Journal Article biblioteca |
Language: | English |
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Wiley
1996-04
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Subjects: | trypanosomiasis, disease resistance, antibodies, cattle, trypanososoma congolense, immunoglobulins, |
Online Access: | https://hdl.handle.net/10568/29382 https://doi.org/10.1046/j.1365-3024.1996.d01-76.x |
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dig-cgspace-10568-293822023-12-27T19:36:23Z The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance Williams, D.J.L. Taylor, K. Newson, J. Gichuki, B. Naessens, Jan trypanosomiasis disease resistance antibodies cattle trypanososoma congolense immunoglobulins It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exposed epitopes of the variable surface glycoprotein in Trypanosoma congolense-infected N'Dama (trypanotolerant) and Boran (susceptible) cattle. Similar titres and isotypes were found in both N'Damas and Borans indicating that trypanotolerance is not associated with superior antibody-mediated destruction of trypanosomes. However, significant differences in antibody responses to cryptic VSG epitopes and non-trypanosome antigens were identified. Trypanosusceptible Boran cattle had low IgG1 responses to cryptic epitopes but high IgM responses to non-trypanosome antigens such as 3-galactosidase. In contrast the N'Dama cattle had significantly higher IgG1 responses to cryptic VSG epitopes and negligible responses to 3-galactosidase. These results indicate differences in the induction of anti-trypanosome immune responses between trypanotolerant and susceptible cattle infected with T. congolense. 1996-04 2013-06-11T09:23:22Z 2013-06-11T09:23:22Z Journal Article Parasite Immunology;18(4): 209-218 0141-9838 https://hdl.handle.net/10568/29382 https://doi.org/10.1046/j.1365-3024.1996.d01-76.x en Copyrighted; all rights reserved Limited Access p. 209-218 Wiley Parasite Immunology |
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trypanosomiasis disease resistance antibodies cattle trypanososoma congolense immunoglobulins trypanosomiasis disease resistance antibodies cattle trypanososoma congolense immunoglobulins |
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trypanosomiasis disease resistance antibodies cattle trypanososoma congolense immunoglobulins trypanosomiasis disease resistance antibodies cattle trypanososoma congolense immunoglobulins Williams, D.J.L. Taylor, K. Newson, J. Gichuki, B. Naessens, Jan The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance |
description |
It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exposed epitopes of the variable surface glycoprotein in Trypanosoma congolense-infected N'Dama (trypanotolerant) and Boran (susceptible) cattle. Similar titres and isotypes were found in both N'Damas and Borans indicating that trypanotolerance is not associated with superior antibody-mediated destruction of trypanosomes. However, significant differences in antibody responses to cryptic VSG epitopes and non-trypanosome antigens were identified. Trypanosusceptible Boran cattle had low IgG1 responses to cryptic epitopes but high IgM responses to non-trypanosome antigens such as 3-galactosidase. In contrast the N'Dama cattle had significantly higher IgG1 responses to cryptic VSG epitopes and negligible responses to 3-galactosidase. These results indicate differences in the induction of anti-trypanosome immune responses between trypanotolerant and susceptible cattle infected with T. congolense. |
format |
Journal Article |
topic_facet |
trypanosomiasis disease resistance antibodies cattle trypanososoma congolense immunoglobulins |
author |
Williams, D.J.L. Taylor, K. Newson, J. Gichuki, B. Naessens, Jan |
author_facet |
Williams, D.J.L. Taylor, K. Newson, J. Gichuki, B. Naessens, Jan |
author_sort |
Williams, D.J.L. |
title |
The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance |
title_short |
The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance |
title_full |
The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance |
title_fullStr |
The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance |
title_full_unstemmed |
The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance |
title_sort |
role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance |
publisher |
Wiley |
publishDate |
1996-04 |
url |
https://hdl.handle.net/10568/29382 https://doi.org/10.1046/j.1365-3024.1996.d01-76.x |
work_keys_str_mv |
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1787229391177121792 |