Further strategies for evaluating the etiological role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis
In 1992, an interdisciplinary research team headquartered at the University of Floridabegan studies in key targeted areas of fibropapillomatosis (FP) etiology andpathogenesis. At that time, little was known about FP outside of field studiesdocumenting its prevalence in different areas of the world and studies of tumorhistopathology. Our primary objective was to develop a broad-based scientificunderstanding of FP by applying principles of tumor biology, immunology, pathology,virology, molecular biology, and epidemiology to FP in the green turtle, Cheloniamydas. Long-term goals included the development of assays for FP and study of anyrole of environmental co-factors in the disease. This report is a continuation of thateffort and the results reported here bring us closer to understanding the role of atumor-associated herpesvirus in marine turtle fibropapillomatosis. This research has demonstrated that marine turtle herpesviruses can persist forextended periods of time as infectious agents in the marine environment and that wildgreen turtles in Florida are exposed to the LETD-associated herpesvirus. This is thefirst description of LETV infection in free-ranging. marine turtles. In addition, data ispresented that supports the hypothesis that LETV and FPHV infections areindependent. These data reveal new levels of complexity that must be addressedbefore reliable serodiagnostic assays for herpesvirus infections of chelonians can bedeveloped for widespread application. The results reported here also raise newconcerns about the potential impact of infections by new herpesviruses on populationsof wild marine turtles, an area which has previously been unexplored by turtlebiologists. (8 page document)
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Format: | monograph biblioteca |
Language: | English |
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Florida Cooperative Fish and Wildlife Research Unit , University of Florida
2001
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Subjects: | Health, Biology, Green turtle, Chelonia mydas, fibropapillomatosis, diseases, Florida, |
Online Access: | http://hdl.handle.net/1834/18968 |
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dig-aquadocs-1834-189682021-07-05T02:46:48Z Further strategies for evaluating the etiological role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis Klein, Paul A. Jacobson, Elliott Health Biology Green turtle Chelonia mydas fibropapillomatosis diseases Florida In 1992, an interdisciplinary research team headquartered at the University of Floridabegan studies in key targeted areas of fibropapillomatosis (FP) etiology andpathogenesis. At that time, little was known about FP outside of field studiesdocumenting its prevalence in different areas of the world and studies of tumorhistopathology. Our primary objective was to develop a broad-based scientificunderstanding of FP by applying principles of tumor biology, immunology, pathology,virology, molecular biology, and epidemiology to FP in the green turtle, Cheloniamydas. Long-term goals included the development of assays for FP and study of anyrole of environmental co-factors in the disease. This report is a continuation of thateffort and the results reported here bring us closer to understanding the role of atumor-associated herpesvirus in marine turtle fibropapillomatosis. This research has demonstrated that marine turtle herpesviruses can persist forextended periods of time as infectious agents in the marine environment and that wildgreen turtles in Florida are exposed to the LETD-associated herpesvirus. This is thefirst description of LETV infection in free-ranging. marine turtles. In addition, data ispresented that supports the hypothesis that LETV and FPHV infections areindependent. These data reveal new levels of complexity that must be addressedbefore reliable serodiagnostic assays for herpesvirus infections of chelonians can bedeveloped for widespread application. The results reported here also raise newconcerns about the potential impact of infections by new herpesviruses on populationsof wild marine turtles, an area which has previously been unexplored by turtlebiologists. (8 page document) Research Work Order no. 194 2021-06-24T14:59:34Z 2021-06-24T14:59:34Z 2001 monograph http://hdl.handle.net/1834/18968 en application/pdf application/pdf Florida Cooperative Fish and Wildlife Research Unit , University of Florida Gainesville, FL http://aquaticcommons.org/id/eprint/1088 3 2011-09-29 21:10:25 1088 Florida Cooperative Fish and Wildlife Research Unit |
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Health Biology Green turtle Chelonia mydas fibropapillomatosis diseases Florida Health Biology Green turtle Chelonia mydas fibropapillomatosis diseases Florida Klein, Paul A. Jacobson, Elliott Further strategies for evaluating the etiological role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis |
description |
In 1992, an interdisciplinary research team headquartered at the University of Floridabegan studies in key targeted areas of fibropapillomatosis (FP) etiology andpathogenesis. At that time, little was known about FP outside of field studiesdocumenting its prevalence in different areas of the world and studies of tumorhistopathology. Our primary objective was to develop a broad-based scientificunderstanding of FP by applying principles of tumor biology, immunology, pathology,virology, molecular biology, and epidemiology to FP in the green turtle, Cheloniamydas. Long-term goals included the development of assays for FP and study of anyrole of environmental co-factors in the disease. This report is a continuation of thateffort and the results reported here bring us closer to understanding the role of atumor-associated herpesvirus in marine turtle fibropapillomatosis. This research has demonstrated that marine turtle herpesviruses can persist forextended periods of time as infectious agents in the marine environment and that wildgreen turtles in Florida are exposed to the LETD-associated herpesvirus. This is thefirst description of LETV infection in free-ranging. marine turtles. In addition, data ispresented that supports the hypothesis that LETV and FPHV infections areindependent. These data reveal new levels of complexity that must be addressedbefore reliable serodiagnostic assays for herpesvirus infections of chelonians can bedeveloped for widespread application. The results reported here also raise newconcerns about the potential impact of infections by new herpesviruses on populationsof wild marine turtles, an area which has previously been unexplored by turtlebiologists. (8 page document) |
format |
monograph |
topic_facet |
Health Biology Green turtle Chelonia mydas fibropapillomatosis diseases Florida |
author |
Klein, Paul A. Jacobson, Elliott |
author_facet |
Klein, Paul A. Jacobson, Elliott |
author_sort |
Klein, Paul A. |
title |
Further strategies for evaluating the etiological role of a
tumor-associated herpesvirus in marine turtle fibropapillomatosis |
title_short |
Further strategies for evaluating the etiological role of a
tumor-associated herpesvirus in marine turtle fibropapillomatosis |
title_full |
Further strategies for evaluating the etiological role of a
tumor-associated herpesvirus in marine turtle fibropapillomatosis |
title_fullStr |
Further strategies for evaluating the etiological role of a
tumor-associated herpesvirus in marine turtle fibropapillomatosis |
title_full_unstemmed |
Further strategies for evaluating the etiological role of a
tumor-associated herpesvirus in marine turtle fibropapillomatosis |
title_sort |
further strategies for evaluating the etiological role of a
tumor-associated herpesvirus in marine turtle fibropapillomatosis |
publisher |
Florida Cooperative Fish and Wildlife Research Unit , University of Florida |
publishDate |
2001 |
url |
http://hdl.handle.net/1834/18968 |
work_keys_str_mv |
AT kleinpaula furtherstrategiesforevaluatingtheetiologicalroleofatumorassociatedherpesvirusinmarineturtlefibropapillomatosis AT jacobsonelliott furtherstrategiesforevaluatingtheetiologicalroleofatumorassociatedherpesvirusinmarineturtlefibropapillomatosis |
_version_ |
1756077168270508032 |