Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines

Heidary Jamebozorgi, F.; Yousefzadi, M.; Firuzi, O.R.; Nazemi, M.; Jassbi, A.R.

Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines

Sponges are the most primitive multicellular eukaryotic organisms and sessile without defense organs therefore, they produce different secondary metabolites to protect themselves from predators and pathogens in their environment. This study aims to evaluation of cytotoxic properties of hexane and dichloromethane parts of methanol extract of the sponge (Ircinia mutans), collected from Larak Island. Hexane and dichloromethane parts were extracted by liquid-liquid extraction from methanol extract then tested by MTT colorimetric assay on three cancer cell lines MOLT-4, MCF-7 and HT-29. The hexane part with IC50 value 11.53 ± 1.3, 41.64 ± 3.5 and 14.57 ± 1.5 μg/mL, and the dichloromethane part with IC50 value 12.51 ± 0.8, 26.6 ± 2.2 and 7.47 ± 0.97 μg/mL respectively, on three mentioned cell line showed moderate to strong cytotoxic activity on all three cancer cell lines. The results also indicate that the dichloromethane part has stronger cytotoxic activity than the hexane part. This study's findings showed the potential of Persian Gulf sponges as valuable sources of new anti-cancer compounds.

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Main Authors:	Heidary Jamebozorgi, F., Yousefzadi, M., Firuzi, O.R., Nazemi, M., Jassbi, A.R.
Format:	Journal Contribution biblioteca
Language:	Persian
Published:	2018
Subjects:	Sponge, Secondary metabolite, Cytotoxic activity,
Online Access:	http://hdl.handle.net/1834/13344
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id	dig-aquadocs-1834-13344
record_format	koha
spelling	dig-aquadocs-1834-133442021-05-19T06:46:12Z Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines Heidary Jamebozorgi, F. Yousefzadi, M. Firuzi, O.R. Nazemi, M. Jassbi, A.R. Sponge Secondary metabolite Cytotoxic activity Sponges are the most primitive multicellular eukaryotic organisms and sessile without defense organs therefore, they produce different secondary metabolites to protect themselves from predators and pathogens in their environment. This study aims to evaluation of cytotoxic properties of hexane and dichloromethane parts of methanol extract of the sponge (Ircinia mutans), collected from Larak Island. Hexane and dichloromethane parts were extracted by liquid-liquid extraction from methanol extract then tested by MTT colorimetric assay on three cancer cell lines MOLT-4, MCF-7 and HT-29. The hexane part with IC50 value 11.53 ± 1.3, 41.64 ± 3.5 and 14.57 ± 1.5 μg/mL, and the dichloromethane part with IC50 value 12.51 ± 0.8, 26.6 ± 2.2 and 7.47 ± 0.97 μg/mL respectively, on three mentioned cell line showed moderate to strong cytotoxic activity on all three cancer cell lines. The results also indicate that the dichloromethane part has stronger cytotoxic activity than the hexane part. This study's findings showed the potential of Persian Gulf sponges as valuable sources of new anti-cancer compounds. Published 2018-07-27T08:35:34Z 2018-07-27T08:35:34Z 2018 Journal Contribution Refereed 1026-1354 http://hdl.handle.net/1834/13344 fa http://isfj.areo.ir/ pp.105-114 Iran Persian Gulf
institution	UNESCO
collection	DSpace
country	Francia
countrycode	FR
component	Bibliográfico
access	En linea
databasecode	dig-aquadocs
tag	biblioteca
region	Europa del Oeste
libraryname	Repositorio AQUADOCS
language	Persian
topic	Sponge Secondary metabolite Cytotoxic activity Sponge Secondary metabolite Cytotoxic activity
spellingShingle	Sponge Secondary metabolite Cytotoxic activity Sponge Secondary metabolite Cytotoxic activity Heidary Jamebozorgi, F. Yousefzadi, M. Firuzi, O.R. Nazemi, M. Jassbi, A.R. Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines
description	Sponges are the most primitive multicellular eukaryotic organisms and sessile without defense organs therefore, they produce different secondary metabolites to protect themselves from predators and pathogens in their environment. This study aims to evaluation of cytotoxic properties of hexane and dichloromethane parts of methanol extract of the sponge (Ircinia mutans), collected from Larak Island. Hexane and dichloromethane parts were extracted by liquid-liquid extraction from methanol extract then tested by MTT colorimetric assay on three cancer cell lines MOLT-4, MCF-7 and HT-29. The hexane part with IC50 value 11.53 ± 1.3, 41.64 ± 3.5 and 14.57 ± 1.5 μg/mL, and the dichloromethane part with IC50 value 12.51 ± 0.8, 26.6 ± 2.2 and 7.47 ± 0.97 μg/mL respectively, on three mentioned cell line showed moderate to strong cytotoxic activity on all three cancer cell lines. The results also indicate that the dichloromethane part has stronger cytotoxic activity than the hexane part. This study's findings showed the potential of Persian Gulf sponges as valuable sources of new anti-cancer compounds.
format	Journal Contribution
topic_facet	Sponge Secondary metabolite Cytotoxic activity
author	Heidary Jamebozorgi, F. Yousefzadi, M. Firuzi, O.R. Nazemi, M. Jassbi, A.R.
author_facet	Heidary Jamebozorgi, F. Yousefzadi, M. Firuzi, O.R. Nazemi, M. Jassbi, A.R.
author_sort	Heidary Jamebozorgi, F.
title	Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines
title_short	Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines
title_full	Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines
title_fullStr	Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines
title_full_unstemmed	Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines
title_sort	cytotoxic activity of hexane and dichloromethane parts of methanol extract of ircinia mutans sponge on three human cancer cell lines
publishDate	2018
url	http://hdl.handle.net/1834/13344
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Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines

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