Multidrug and multispecies resistance in sheep flocks from São Paulo state, Brazil.

The economic importance of sheep production is increasing worldwide simultaneously with the emergence of parasitic resistance. This study aimed to survey the current situation of management practices and parasite resistance in sheep flocks in São Paulo state, Brazil. A questionnaire was given to 35 sheep farmers to obtain information related to flock management practices. Of these flocks, 30 were submitted to the fecal egg count reduction test (FECRT) with at least one of the five following anthelmintics: albendazole, closantel, ivermectin, levamisole, and moxidectin, for comparison against an untreated control group. In the survey, the median number animals per flock was 301, mainly of the Santa Ines breed (in 75.8% of the flocks) and crossbred animals (in 54.5% of the flocks). The predominant farming system was semi-intensive (82.9%), using rotational grazing (80%). Selective treatment was based on FAMACHA grade (47.1%) and in clinical signs (41.2%). The most often applied anthelmintics were macrocyclic lactones (42.9?54.2% in the last three applications). Considering the anthelmintics employed in this study, 10.7% of the farms? flocks were resistant to three, 35.7% to four, and 53.6% to all five anthelmintics. The main helminth genera observed before and after treatments were Haemonchus sp. (75.8%) and Trichostrongylus sp. (19.1%), but all observed genera (Cooperia sp., Oesophagostomum sp., and Strongyloides sp.) were detected by the FECRT. Considering efficacy values less than or equal to 90% in the FECRT as resistant, 100% of flocks were resistant to albendazole and ivermectin, 96.6% to moxidectin, 92.9% to closantel, and 53.6% to levamisole. It is thus possible to conclude that multidrug resistance is widespread in sheep flocks in São Paulo state, Brazil, and this involves all prevalent helminth genera.

Bibliographic Details

Main Authors:	VERÍSSIMO, C. J., NICIURA, S. C. M., ALBERTI, A. L., RODRIGUES, C. F. C., BARBOSA, C. M. P., CHIEBAO, D. F., CARDOSO, D., SILVA, G. S. da, PEREIRA, J. R., MARGATHO, L. F. F., COSTA, R. L. D. da, NARDON, R. F., UENO, T. E. H., CURCI, V. L. L. M., MOLENTO, M. B.
Other Authors:	CECÍLIA JOSÉ VERÍSSIMO, INSTITUTO DE ZOOTECNIA/NOVA ODESSA; SIMONE CRISTINA MEO NICIURA, CPPSE; ANA LÚCIA LUZ ALBERTI, APTA PÓLO REGIONAL ALTA SOROCABANA/PRESIDENTE PRUDENTE; CARLOS FREDERICO CARVALHO RODRIGUES, APTA PÓLO REGIONAL SUDOESTE PAULISTA, UPD DE ITAPETININGA/ITAPETININGA; CRISTINA MARIA PACHECO BARBOSA, APTA PÓLO REGIONAL SUDOESTE PAULISTA, UPD DE ITAPETININGA/ITAPETININGA; DANIELA PONTES CHIEBAO, APTA PÓLO REGIONAL CENTRO, UPD DE SOROCABA/SOROCABA; DANIEL CARDOSO, APTA PÓLO REGIONAL EXTREMO OESTE, UPD DE ARAÇATUBA/ARAÇATUBA; GIANE SERAFIM DA SILVA, APTA PÓLO REGIONAL NOROESTE PAULISTA/VOTUPORANGA; JOSÉ ROBERTO PEREIRA, APTA PÓLO REGIONAL VALE DO PARAÍBA/PINDAMONHAGABA; LUIZ FLORÊNCIO FRANCO MARGATHO, APTA PÓLO REGIONAL CENTRO OESTE, UPD DE BAURU/BAURU; RICARDO LOPES DIAS DA COSTA, APTA PÓLO REGIONAL ALTA SOROCABANA/PRESIDENTE PRUDENTE; ROMEU FERNANDES NARDON, APTA PÓLO REGIONAL ALTA SOROCABANA/ASSIS; TATIANA EVELYN HAYAMA UENO, APTA PÓLO REGIONAL CENTRO NORTE, UPD DE SÃO JOSÉ DO RIO PRETO/SÃO JOSÉ DO RIO PRETO; VERA CLÁUDIA LORENZETTI MAGALHÃES CURCI, DEPARTAMENTO DE MEDICINA VETERINÁRIA, UNIVERSIDADE FEDERAL DO PARANÁ/CURITIBA; MARCELO BELTRÃO MOLENTO, INSTITUTO DE ZOOTECNIA.
Format:	Artigo de periódico biblioteca
Language:	Ingles English
Published:	2012-03-06
Subjects:	Efficacy Helminths, Management practices, drug resistance, questionnaires,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/917633
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