Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats.
It has been suggested that, in some cases, exposure to environmental contaminants affects children more profoundly than adults. It is important to evaluate adverse health outcomes in children, a population susceptible to toxic chemicals and mixtures. We examined the effects that maternal exposure to two pesticides had on maturational aspects of offspring development during the nursing period. Nursing female rats were exposed to 1-4 mg/kg of intraperitoneal methamidophos, 200?800 mg/kg of chlorothalonil, or both. The higher doses of methamidophos affected pup viability by day 21 of life. Both pesticides, alone or together, affected body weight gain of dams and offspring. Developmental milestones evaluated in the pups were incisor eruption, ear unfolding, eye opening and testis descent. Although no clear dose-response relationship was established between these milestones and exposure to methamidophos or chlorothalonil, incisor eruption was accelerated in many groups, and the majority of rat offspring exposed to methamidophos presented later ear unfolding and eye opening than did the control group offspring. Sexual maturation (testis descent) was significantly delayed in some groups. For dams and pups alike, simultaneous exposure to both pesticides was not found to have a greater toxic effect than that resulting from exposure to only one of the two. Taken together, these results demonstrate exposure-related influences on several developmental measures. Detection of more subtle effects may be improved through the use of the developmental temporal response protocols utilized in this study.
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Separatas biblioteca |
Language: | English eng |
Published: |
2008-01-15
|
Subjects: | Teste, Clorotalonil, Metamidafós, Saúde humana, Erupção, Protocolo., Agrotóxico, Contaminação, Exposição, Pesticida, Toxidez., |
Online Access: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/15998 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-alice-doc-15998 |
---|---|
record_format |
koha |
spelling |
dig-alice-doc-159982017-08-16T00:51:59Z Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. CASTRO, V. L. S. S. de CHIORATO, S. H. Vera Lúcia Scherholz Salgado de Castro, Embrapa Meio Ambiente; Selma Heloísa Chiorato, FMVZ-USP. Teste Clorotalonil Metamidafós Saúde humana Erupção Protocolo. Agrotóxico Contaminação Exposição Pesticida Toxidez. It has been suggested that, in some cases, exposure to environmental contaminants affects children more profoundly than adults. It is important to evaluate adverse health outcomes in children, a population susceptible to toxic chemicals and mixtures. We examined the effects that maternal exposure to two pesticides had on maturational aspects of offspring development during the nursing period. Nursing female rats were exposed to 1-4 mg/kg of intraperitoneal methamidophos, 200?800 mg/kg of chlorothalonil, or both. The higher doses of methamidophos affected pup viability by day 21 of life. Both pesticides, alone or together, affected body weight gain of dams and offspring. Developmental milestones evaluated in the pups were incisor eruption, ear unfolding, eye opening and testis descent. Although no clear dose-response relationship was established between these milestones and exposure to methamidophos or chlorothalonil, incisor eruption was accelerated in many groups, and the majority of rat offspring exposed to methamidophos presented later ear unfolding and eye opening than did the control group offspring. Sexual maturation (testis descent) was significantly delayed in some groups. For dams and pups alike, simultaneous exposure to both pesticides was not found to have a greater toxic effect than that resulting from exposure to only one of the two. Taken together, these results demonstrate exposure-related influences on several developmental measures. Detection of more subtle effects may be improved through the use of the developmental temporal response protocols utilized in this study. 2014-03-25T20:50:26Z 2014-03-25T20:50:26Z 2008-01-15 2007 2014-03-25T20:50:26Z Separatas International Journal of Hygiene and Environmental Health, Jena, v. 210, n.2, p. 169-176, 2007. http://www.alice.cnptia.embrapa.br/alice/handle/doc/15998 en eng openAccess |
institution |
EMBRAPA |
collection |
DSpace |
country |
Brasil |
countrycode |
BR |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-alice |
tag |
biblioteca |
region |
America del Sur |
libraryname |
Sistema de bibliotecas de EMBRAPA |
language |
English eng |
topic |
Teste Clorotalonil Metamidafós Saúde humana Erupção Protocolo. Agrotóxico Contaminação Exposição Pesticida Toxidez. Teste Clorotalonil Metamidafós Saúde humana Erupção Protocolo. Agrotóxico Contaminação Exposição Pesticida Toxidez. |
spellingShingle |
Teste Clorotalonil Metamidafós Saúde humana Erupção Protocolo. Agrotóxico Contaminação Exposição Pesticida Toxidez. Teste Clorotalonil Metamidafós Saúde humana Erupção Protocolo. Agrotóxico Contaminação Exposição Pesticida Toxidez. CASTRO, V. L. S. S. de CHIORATO, S. H. Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. |
description |
It has been suggested that, in some cases, exposure to environmental contaminants affects children more profoundly than adults. It is important to evaluate adverse health outcomes in children, a population susceptible to toxic chemicals and mixtures. We examined the effects that maternal exposure to two pesticides had on maturational aspects of offspring development during the nursing period. Nursing female rats were exposed to 1-4 mg/kg of intraperitoneal methamidophos, 200?800 mg/kg of chlorothalonil, or both. The higher doses of methamidophos affected pup viability by day 21 of life. Both pesticides, alone or together, affected body weight gain of dams and offspring. Developmental milestones evaluated in the pups were incisor eruption, ear unfolding, eye opening and testis descent. Although no clear dose-response relationship was established between these milestones and exposure to methamidophos or chlorothalonil, incisor eruption was accelerated in many groups, and the majority of rat offspring exposed to methamidophos presented later ear unfolding and eye opening than did the control group offspring. Sexual maturation (testis descent) was significantly delayed in some groups. For dams and pups alike, simultaneous exposure to both pesticides was not found to have a greater toxic effect than that resulting from exposure to only one of the two. Taken together, these results demonstrate exposure-related influences on several developmental measures. Detection of more subtle effects may be improved through the use of the developmental temporal response protocols utilized in this study. |
author2 |
Vera Lúcia Scherholz Salgado de Castro, Embrapa Meio Ambiente; Selma Heloísa Chiorato, FMVZ-USP. |
author_facet |
Vera Lúcia Scherholz Salgado de Castro, Embrapa Meio Ambiente; Selma Heloísa Chiorato, FMVZ-USP. CASTRO, V. L. S. S. de CHIORATO, S. H. |
format |
Separatas |
topic_facet |
Teste Clorotalonil Metamidafós Saúde humana Erupção Protocolo. Agrotóxico Contaminação Exposição Pesticida Toxidez. |
author |
CASTRO, V. L. S. S. de CHIORATO, S. H. |
author_sort |
CASTRO, V. L. S. S. de |
title |
Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. |
title_short |
Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. |
title_full |
Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. |
title_fullStr |
Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. |
title_full_unstemmed |
Effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. |
title_sort |
effects of separate and combined exposure to the pesticides methamidophos and chlorothalonil on the development of suckling rats. |
publishDate |
2008-01-15 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/15998 |
work_keys_str_mv |
AT castrovlssde effectsofseparateandcombinedexposuretothepesticidesmethamidophosandchlorothalonilonthedevelopmentofsucklingrats AT chioratosh effectsofseparateandcombinedexposuretothepesticidesmethamidophosandchlorothalonilonthedevelopmentofsucklingrats |
_version_ |
1756019383775264768 |